Patents by Inventor Eli Wallace

Eli Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
    Publication number: 20070299063
    Abstract: Disclosed are amino acid prodrugs of compounds of the formula I and pharmaceutically acceptable salts thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 27, 2007
    Applicant: Array BioPharma, Inc.
    Inventors: Eli Wallace, Joseph Lyssikatos, Allison Marlow, T. Hurley, Kevin Koch
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Patent number: 7230099
    Abstract: Disclosed are compounds of the Formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: June 12, 2007
    Assignee: Array BioPharma, Inc.
    Inventors: Eli Wallace, Brian Hurley, Hong Woon Yang, Joseph Lyssikatos, Jim Blake, Alison Marlow
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20070112038
    Abstract: Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: May 17, 2006
    Publication date: May 17, 2007
    Inventors: Allison Marlow, Eli Wallace, Jeongbeob Seo, Joseph Lyssikatos, Hong Yang, James Blake
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Patent number: 7144907
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: December 5, 2006
    Assignee: Array Biopharma Inc.
    Inventors: Eli Wallace, Brian Hurley, Hon Woon Yang, Joseph Lyssikatos, Jim Blake
  • Mitotic kinesin inhibitors and methods of use thereof
    Publication number: 20060247178
    Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: May 1, 2006
    Publication date: November 2, 2006
    Inventors: Jeremy Hans, Eli Wallace, Qian Zhao, Shelley Allen, Ellen Laird, Joseph Lyssikatos, John Robinson, Christopher Corrette, Robert Delisle
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20060189808
    Abstract: Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 24, 2006
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Eli Wallace, Brian Hurley, Joseph Lyssikatos, Jim Blake
  • Method of treating hyperproliferative disorders using heterocyclic inhibitors of MEK
    Publication number: 20060189668
    Abstract: Disclosed are methods of inhibiting MEK activity, comprising administering to a mammal an effective amount of a compound of Formula I or IV or a solvate or pharmaceutically acceptable salt thereof, wherein R1, R2, R7, R8, R9, R10, W and Y are as defined in the specification. Also disclosed are methods of treating hyperproliferative diseases, such as cancer and inflammation, in mammals, said method comprising administering to a mammal an effective amount of a compound of Formula I or IV.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 24, 2006
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Eli Wallace, Hong Yang, Jim Blake
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20060189649
    Abstract: Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R11 and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 24, 2006
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Eli Wallace, Jim Blake
  • N3 alkylated benzimidazole derivatives as MEK inhibitors
    Publication number: 20060106225
    Abstract: Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R1, R2, R7, R9, R10, R11 and R12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: October 25, 2005
    Publication date: May 18, 2006
    Inventors: Eli Wallace, Joseph Lyssikatos, Allison Marlow, T. Hurley
  • Mitotic kinesin inhibitors and methods of use thereof
    Publication number: 20060100161
    Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: October 17, 2005
    Publication date: May 11, 2006
    Inventors: Jeremy Hans, Eli Wallace, Qian Zhao, Joseph Lyssikatos, Thomas Aicher, Ellen Laird, John Robinson, Shelley Allen
  • Method of treating inflammatory diseases
    Publication number: 20060030610
    Abstract: Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.
    Type: Application
    Filed: August 19, 2005
    Publication date: February 9, 2006
    Inventors: Kevin Koch, T. Hurley, Hong Yang, Joseph Lyssikatos, James Blake, Allison Marlow, Eli Wallace
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050256123
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: May 18, 2005
    Publication date: November 17, 2005
    Inventors: Allison Marlow, Eli Wallace, Jeongbeob Seo, Joseph Lyssikatos, Hong Yang, James Blake
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050250782
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specifications. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 18, 2004
    Publication date: November 10, 2005
    Inventors: Allison Marlow, Eli Wallace, Jeongbeob Seo, Joseph Lyssikatos, Hong Yang, James Blake
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050153942
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 18, 2004
    Publication date: July 14, 2005
    Inventors: Eli Wallace, Jeongbeob Seo, Joseph Lyssikatos, Hong Yang, T. Hurley, Allison Marlow, James Blake
  • N3 alkylated benzimidazole derivatives as MEk inhibitors
    Publication number: 20050143438
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: February 18, 2005
    Publication date: June 30, 2005
    Inventors: Eli Wallace, Joseph Lyssikatos, Allison Marlow, T. Hurley
  • Bicyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050130976
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 16, 2005
    Inventors: Eli Wallace, Hong Yang, James Blake
  • Bicyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050130943
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R20, R21, and R22 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 16, 2005
    Inventors: Eli Wallace, Joseph Lyssikatos, Hong Yang
  • Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
    Publication number: 20050101617
    Abstract: Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
    Type: Application
    Filed: November 10, 2003
    Publication date: May 12, 2005
    Inventors: Eli Wallace, George Topolov, Qian Zhao, Joseph Lyssikatos
  • Quinazoline analogs as receptor tyrosine kinase inhibitors
    Publication number: 20050101616
    Abstract: This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: August 14, 2003
    Publication date: May 12, 2005
    Inventors: Eli Wallace, George Topalov, Joseph Lyssikatos, Alexandre Buckmelter, Qian Zhao
  • Heterocyclic inhibitors of MEK and methods of use thereof
    Publication number: 20050054701
    Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: August 30, 2004
    Publication date: March 10, 2005
    Inventors: Eli Wallace, Brian Hurley, Hong Yang, Joseph Lyssikatos, Jim Blake, Allison Marlow