Patents by Inventor Eliahu Heldman

Eliahu Heldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190381137
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: December 19, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190216895
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2—L1—HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: November 12, 2018
    Publication date: July 18, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190076533
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 14, 2019
    Inventors: Charles LINDER, Eliahu Heldman, Sarina Grinberg
  • Publication number: 20180303818
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Application
    Filed: November 30, 2017
    Publication date: October 25, 2018
    Inventor: Eliahu Heldman
  • Publication number: 20180036376
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 8, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20180021368
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: June 30, 2017
    Publication date: January 25, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20170367980
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: May 9, 2017
    Publication date: December 28, 2017
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Publication number: 20170128432
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Application
    Filed: September 8, 2016
    Publication date: May 11, 2017
    Inventor: Eliahu Heldman
  • Patent number: 9642803
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 9, 2017
    Assignee: Ben-Gurion University Of The Negev Research And Development Authority
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Publication number: 20160367678
    Abstract: Bolaamphiphilic compounds are provided according to formula I: where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: April 15, 2016
    Publication date: December 22, 2016
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150306236
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: October 29, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150306109
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Application
    Filed: November 26, 2014
    Publication date: October 29, 2015
    Inventor: Eliahu Heldman
  • Publication number: 20150246138
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2 -L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 3, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150238611
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: August 27, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150110875
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 23, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Publication number: 20150104502
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 16, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Patent number: 8921356
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: December 30, 2014
    Assignee: NeuroDerm, Ltd.
    Inventor: Eliahu Heldman
  • Publication number: 20130172321
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Application
    Filed: August 24, 2012
    Publication date: July 4, 2013
    Inventor: Eliahu Heldman
  • Patent number: 8377469
    Abstract: Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.
    Type: Grant
    Filed: January 2, 2006
    Date of Patent: February 19, 2013
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Jacob Zabicky, Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Patent number: 8273731
    Abstract: The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in particular, to combination therapies that include a nicotinic agonist (for example, nicotine) and a nicotinic acetylcholine receptor desensitization inhibitor (for example, opipramol).
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: September 25, 2012
    Assignee: Neuroderm Ltd.
    Inventor: Eliahu Heldman