Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.

Abstract: An ultrasound imaging system may analyze motion of landmarks in a temporal sequence of image frames to determine mobility of one or more landmarks. In some examples, the sequence of image frames may be analyzed by one or more artificial intelligence models to detect landmarks and generate flow fields for the detected landmarks. The flow fields may be analyzed to determine the isotropy of the movement of the landmarks. The isotropy analysis may be used to generate a quantitative mobility index.

Abstract: The present invention relates to topical compositions that can be used to treat melanin or pigmentation disorders and methods of using the compositions.

Abstract: An approach for an automated task management system to accomplish set goals by completing a predefined set of tasks for that goal is disclosed. The approach includes creating a goal object by one or more users and creating one or more task objects associated with the goal object by the one or more users. The approach includes executing a first task of the one or more task objects and determining if there is one or more deviations associated with executing the first task. Users can directly define deviations which are stored into the tasks directly as a deviation path without needing admin approval. Based on determining there is the one or more deviations, the approach can optionally ask for an approval from an administrator. Deviation tasks objects are stored into the goal object for future users to view and use.

Abstract: An approach for an automated task management system to accomplish set goals by completing a predefined set of tasks for that goal is disclosed. The approach includes creating a goal object by one or more users and creating one or more task objects associated with the goal object by the one or more users. The approach includes executing a first task of the one or more task objects and determining if there is one or more deviations associated with executing the first task. Users can directly define deviations which are stored into the tasks directly as a deviation path without needing admin approval. Based on determining there is the one or more deviations, the approach can optionally ask for an approval from an administrator. Deviation tasks objects are stored into the goal object for future users to view and use.

Abstract: Disclosed herein are recombinant proteins including an IGFBP3 or a biologically active fragment thereof and an IgG Fc portion linked to the C-terminus of the IGFBP3 variant. The recombinant proteins including at least one additional domain of other growth factors are also disclosed. Methods for treating tumors, in particular, tumors resistant to the targeted therapy, using the above-mentioned recombinant proteins are also provided.

Abstract: A computer-implemented method includes: receiving, by a computer device, input to tag at least one line of code with one of plural predefined types of metadata tags, wherein the at least one line of code is a subset of a source code that is stored in a code repository and editable by plural different users via a client source code editor program; tagging, by the computer device, the at least one line of code with the one of the plural predefined types of metadata tags; detecting, by the computer device, a change to the at least one line of code after the tagging; and generating, by the computer device, an alert based on the detecting the change to the at least one line of code.

Abstract: Computer-implemented methods, systems, and computer program products are disclosed in which a first computing device sends a meeting request for person(s) to a second computing device. The first computing device receives from the second computing device, first token(s) granting limited access to calendar information for the person(s) sufficient for conflict clearance, the token(s) having restriction(s). The restriction(s) include one or more of a lifespan for the limited access, an identification of which calendar entries are accessible, an indication of how much of a calendar entry is accessible, a use count for the limited access, showing only available time and encryption of the calendar information. The first computing device sends to the second computing device, a meeting invitation for the person(s) based on the limited access. The first computing device then receives from the second computing device, an acceptance for the meeting invitation.

Abstract: A computer-implemented method includes: receiving, by a computer device, input to tag at least one line of code with one of plural predefined types of metadata tags, wherein the at least one line of code is a subset of a source code that is stored in a code repository and editable by plural different users via a client source code editor program; tagging, by the computer device, the at least one line of code with the one of the plural predefined types of metadata tags; detecting, by the computer device, a change to the at least one line of code after the tagging; and generating, by the computer device, an alert based on the detecting the change to the at least one line of code.

Abstract: Disclosed herein are recombinant proteins including an IGFBP3 or a biologically active fragment thereof and an IgG Fc portion linked to the C-terminus of the IGFBP3 variant. The recombinant proteins including at least one additional domain of other growth factors are also disclosed. Methods for treating tumors, in particular, tumors resistant to the targeted therapy, using the above-mentioned recombinant proteins are also provided.

Abstract: The present application is directed to the discovery that preparations of hedgehog polypeptides can be used to control the formation and/or maintenance of epithelial tissue.

Abstract: The present application is directed to the discovery that preparations of hedgehog polypeptides can be used to control the formation and/or maintenance of epithelial tissue.

Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

Abstract: One aspect of the present application relates to a method for modulating the growth state of an epithelial cell by ectopically contacting the epithelial cell, in vitro or in vivo, with a hedgehog therapeutic or ptc therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of the epithelial cell, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of an epithelial tissue, such as for inducing the formation of skin or other cutaneous tissue, or for inducing growth of hair.

Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

Abstract: The present invention provides novel methods and compositions for promoting proliferation and/or regeneration.

Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

Abstract: A keyboard in which one or more individual keys of the keyboard can be vibrated selectively. Thus, when a particular combination of keys or a single key needs to be activated, the user can identify the required key(s) by touch rather than by vision.

Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.