Patents by Inventor Elizabeth C. Squiers
Elizabeth C. Squiers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180305696Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.Type: ApplicationFiled: December 5, 2017Publication date: October 25, 2018Inventors: Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Nir Sharon, Daniel J. Odenheimer, Elena Feinstein
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Patent number: 10093923Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: GrantFiled: October 27, 2015Date of Patent: October 9, 2018Assignee: NITTO DENKO CORPORATIONInventors: Xiaomei Jin, Lei Yu, Hirokazu Takahashi, Yasunobu Tanaka, Yoshiro Niitsu, Elena Feinstein, Sharon Avkin-Nachum, Hagar Kalinski, Igor Mett, Shai Erlich, Elizabeth C Squiers, Ning Chen
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Publication number: 20180098964Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of geneic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these sub-populations.Type: ApplicationFiled: October 19, 2017Publication date: April 12, 2018Inventors: Thomas E. DALEY, Elizabeth C. SQUIERS, Kin-Hung P. YU
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Patent number: 9868953Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.Type: GrantFiled: July 14, 2017Date of Patent: January 16, 2018Assignee: Quark Pharmaceuticals, Inc.Inventors: Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Nir Sharon, Daniel J. Odenheimer, Elena Feinstein
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Publication number: 20170335327Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.Type: ApplicationFiled: July 14, 2017Publication date: November 23, 2017Inventors: Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Nir Sharon, Daniel J. Odenheimer, Elena Feinstein
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Publication number: 20170081665Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.Type: ApplicationFiled: May 27, 2015Publication date: March 23, 2017Applicant: Quark Pharmaceuticals, Inc.Inventors: Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Nir Sharon, Daniel J. Odenheimer, Elena Feinstein
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Publication number: 20170007578Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydro genase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.Type: ApplicationFiled: September 20, 2016Publication date: January 12, 2017Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung P. Yu
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Publication number: 20160243082Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.Type: ApplicationFiled: May 2, 2016Publication date: August 25, 2016Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
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Patent number: 9326971Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.Type: GrantFiled: February 5, 2014Date of Patent: May 3, 2016Assignee: RAPTOR PHARMACEUTICALS INC.Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
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Publication number: 20160108399Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: ApplicationFiled: October 27, 2015Publication date: April 21, 2016Applicant: NITTO DENKO CORPORATIONInventors: Xiaomei JIN, Lei YU, Hirokazu TAKAHASHI, Yasunobu TANAKA, Yoshiro NIITSU, Elena FEINSTEIN, Sharon AVKIN-NACHUM, Hagar KALINSKI, Igor METT, Shai ERLICH, Elizabeth C. SQUIERS, Ning CHEN
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Patent number: 9206424Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: GrantFiled: March 18, 2014Date of Patent: December 8, 2015Assignee: NITTO DENKO CORPORATIONInventors: Xiaomei Jin, Lei Yu, Hirokazu Takahashi, Yasunobu Tanaka, Yoshiro Niitsu, Elena Feinstein, Sharon Avkin-Nachum, Hagar Kalinski, Igor Mett, Shai Erlich, Elizabeth C Squiers, Ning Chen
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Publication number: 20140235695Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: ApplicationFiled: March 18, 2014Publication date: August 21, 2014Inventors: Xiaomei JIN, Lei YU, Hirokazu TAKAHASHI, Yasunobu TANAKA, Yoshiro NIITSU, Elena FEINSTEIN, Sharon AVKIN-NACHUM, Hagar KALINSKI, Igor METT, Shai ERLICH, Elizabeth C SQUIERS, Ning CHEN
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Publication number: 20140155450Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.Type: ApplicationFiled: February 5, 2014Publication date: June 5, 2014Applicant: Raptor Pharmaceuticals Inc.Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
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Patent number: 8710209Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: GrantFiled: December 8, 2010Date of Patent: April 29, 2014Assignee: Nitto Denko CorporationInventors: Xiaomei Jin, Lei Yu, Hirokazu Takahashi, Yasunobu Tanaka, Yoshiro Niitsu, Elena Feinstein, Sharon Avkin-Nachum, Hagar Kalinski, Igor Mett, Shai Erlich, Elizabeth C. Squiers, Ning Chen
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Publication number: 20120322843Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.Type: ApplicationFiled: June 21, 2012Publication date: December 20, 2012Applicant: RAPTOR THERAPEUTICS INC.Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
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Publication number: 20120252857Abstract: Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.Type: ApplicationFiled: June 9, 2010Publication date: October 4, 2012Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu
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Publication number: 20110178157Abstract: Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.Type: ApplicationFiled: December 8, 2010Publication date: July 21, 2011Inventors: Xiaomei Jin, Lei Yu, Hirokazu Takahashi, Yasunobu Tanaka, Yoshiro Niitsu, Elena Feinstein, Sharon Avkin-Nachum, Hagar Kalinski, Igor Mett, Shai Erlich, Elizabeth C. Squiers
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Publication number: 20110053999Abstract: Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.Type: ApplicationFiled: June 9, 2010Publication date: March 3, 2011Inventors: Thomas E. Daley, Elizabeth C. Squiers, Kin-Hung Peony Yu