Patents by Inventor Elizabeth NANCE

Elizabeth NANCE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240335515
    Abstract: Enzyme-loaded polymeric nanoparticles for the treatment of disorders such as neurological or non-neurological conditions are described. Using hydrophobic ion pairing, enzymes are loaded into polymeric nanoparticles while retaining enzymatic activity. Surfactants coating the nanoparticle can direct nanoparticles for cellular uptake or for aggregation in the extracellular matrix. Preparing a hydrophobic ion pairing complex for nanoparticle formation.
    Type: Application
    Filed: July 12, 2022
    Publication date: October 10, 2024
    Applicant: University of Washington
    Inventors: ELIZABETH NANCE, ANDREA JOSEPH, CHRIS NYAMBURA, WALTER JAMES PFAENDTNER, THOMAS WOOD
  • Patent number: 10307372
    Abstract: Non-adhesive particles as large as 110 nm can diffuse rapidly in the brain ECS, if coated with hydrophilic coatings such as PEG coatings and preferably having neutral surface charge. The ability to achieve brain penetration with larger particles will significantly improve drug and gene delivery within the CNS since larger particles offer higher drug payload, improved drug loading efficiency, and significantly longer drug release durations.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: June 4, 2019
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Justin Hanes, Graeme F. Woodworth, Elizabeth A. Nance
  • Publication number: 20170232120
    Abstract: A dendrimer formation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for systemic administration to the brain or central nervous system. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of neurodegenerative, neurodevelopmental or neurological disorders such as Rett syndrome or autism spectrum disorders, D6 generation dendrimers provide significantly enhanced uptake into areas of brain Injury, providing a means for diagnosis as well, as drug delivery.
    Type: Application
    Filed: August 13, 2015
    Publication date: August 17, 2017
    Inventors: Kannan RANGARAMANUJAM, Sujatha KANNAN, Elizabeth NANCE, Mary E. BLUE, Michael V. JOHNSTON, William BAUMGARTNER, Fan ZHANG, Mary Ann WILSON, Barbara SLUSHER
  • Publication number: 20130183244
    Abstract: Non-adhesive particles as large as 110 nm can diffuse rapidly in the brain ECS, if coated with hydrophilic coatings such as PEG coatings and preferably having neutral surface charge. The ability to achieve brain penetration with larger particles will significantly improve drug and gene delivery within the CNS since larger particles offer higher drug payload, improved drug loading efficiency, and significantly longer drug release durations.
    Type: Application
    Filed: September 12, 2011
    Publication date: July 18, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Justin Hanes, Graeme F. Woodworth, Elizabeth A. Nance