Patents by Inventor Emanuel Petricoin

Emanuel Petricoin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170363630
    Abstract: Disclosed herein are methods for treating subjects with breast cancer, comprising determining a therapeutic regimen for cancer by measuring the level (amount) of proteins of one or more biomarkers. Also disclosed are methods of predicting or assessing therapeutic outcome for subject.
    Type: Application
    Filed: December 8, 2015
    Publication date: December 21, 2017
    Inventors: Emanuel PETRICOIN, Julia WULFKUHLE
  • Publication number: 20170160282
    Abstract: Disclosed herein are methods for treating subjects with breast cancer, comprising determining a therapeutic regimen for cancer by measuring the level (amount) of proteins of one or more biomarkers. Also disclosed are methods of treating a subject with breast cancer by predicting or assessing a therapeutic outcome for subject.
    Type: Application
    Filed: December 7, 2016
    Publication date: June 8, 2017
    Inventors: Emanuel Petricoin, Julia Wulfkuhle
  • Patent number: 9383299
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: July 5, 2016
    Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.
    Inventors: Alessandra Luchini Kunkel, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M Dunlap, Alexis Patanarut
  • Patent number: 9005996
    Abstract: The current invention is a capture-particle comprising: a) a molecular sieve portion; and b) an analyte binding portion; wherein the molecular sieve portion, analyte binding portion or both further comprise a cross-linked region having modified porosity. Capture particles wherein the molecular sieve portion, analyte binding portion or both comprise pore dimensions sufficient to exclude molecules larger than about 60 kDa. These particles are useful in purification and diagnostic methods. Kits comprising the capture particles are also described.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: April 14, 2015
    Assignee: George Mason Research Foundation
    Inventors: Lance Liotta, Emanuel Petricoin, David Geho
  • Publication number: 20140045274
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Application
    Filed: February 25, 2013
    Publication date: February 13, 2014
    Inventors: Alessandra Luchini Kunkel, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M. Dunlap, Alexis Patanarut
  • Publication number: 20130344062
    Abstract: This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 26, 2013
    Inventors: Emanuel Petricoin, III, Julia Wulfkuhle, Angela Zupa
  • Publication number: 20130243700
    Abstract: The present invention provides compositions and methods for shielding and directing agents to biological targets in cellular systems for therapeutic, prophylactic, and diagnostic uses. Vascular devices are also provided which have coated surfaces that contain proteomic antisense, as well as therapeutic and other biological agents attached thereto.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 19, 2013
    Inventors: Lance Liotta, David Geho, Emanuel Petricoin
  • Patent number: 8497137
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: July 30, 2013
    Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Caterina Longo, Virginia Espina, Alexis Patanarut
  • Patent number: 8382987
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: February 26, 2013
    Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M Dunlap, Alexis Patanarut
  • Publication number: 20120321615
    Abstract: Disclosed herein is a method for predicting the prognosis, the likelihood of metastasis in, or the desirability of administering an aggressive therapy to, a subject with colorectal cancer, comprising determining, in a sample from the subject, the level of phosphorylation of one or more of certain proteins compared to a positive and/or negative reference standard; or the total amount of COX-2 protein compared to a positive and/or negative reference standard. Also described are methods for treating subjects likely to develop metastatic colorectal carcinoma, and pharmaceutical compositions and kits for implementing the methods of the invention.
    Type: Application
    Filed: May 25, 2012
    Publication date: December 20, 2012
    Inventors: Emanuel Petricoin, III, Lance A. Liotta, Mariaelena Pierobon, Valerie Calvert
  • Publication number: 20120164749
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Application
    Filed: August 19, 2008
    Publication date: June 28, 2012
    Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Caterina Longo, Virginia Espina, Alexis Patanarut
  • Publication number: 20120083422
    Abstract: Glioblastoma multiforme biomarkers, methods, and compositions are provided. Methods of selecting a treatment for a patient with a brain neoplasm, including Glioblastoma multiforme, are provided. Methods of treating a patient at risk for Glioblastoma multiforme are provided.
    Type: Application
    Filed: June 2, 2011
    Publication date: April 5, 2012
    Inventors: Claudius Mueller, Lance Liotta, Emanuel Petricoin, Virginia Espina
  • Publication number: 20120076770
    Abstract: THE INVENTION RELATES TO compounds, proteins and methods of treatment therewith. Aspects of embodiments of the invention further relates to compounds and methods of treatment for bone, bone marrow, and bone tissue.
    Type: Application
    Filed: March 28, 2011
    Publication date: March 29, 2012
    Inventors: Virginia Espina, Lance Liotta, Antonella Chiechi, Alessandra Romano, Emanuel Petricoin, Amy Van Meter
  • Publication number: 20110318336
    Abstract: This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.
    Type: Application
    Filed: March 29, 2011
    Publication date: December 29, 2011
    Applicant: George Mason Intellectual Properties, Inc.
    Inventors: Emanuel Petricoin, III, Julia Wulfkuhle, Angela Zupa
  • Publication number: 20110137627
    Abstract: A system and method for creating at least one new network, comprising: selecting at least one node and at least one set of reactions where reagents in each reaction of the at least one set of reactions are known in at least one reference network; and creating at least one new network by causing the at least one new network to behave in a similar way with respect to the at least one node and the at least one set of reactions as the at least one reference network reacts with the at least one node and the at least one set of reactions.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 9, 2011
    Inventors: Domenico NAPOLETANI, Michele Signore, Timothy Sauer, Lance Liotta, Emanuel Petricoin
  • Patent number: 7935518
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles may be changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: May 3, 2011
    Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, David Geho
  • Publication number: 20110046039
    Abstract: The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying non-lethal and lethal exposure to anthrax and similar disease vectors. Embodiments provide materials and methods for using the strains and model systems for differential profiling, such as proteomic profiling, such as differentiation phosphorylation profiling, to target identification and therapeutics discovery and development. Embodiments provide pharmaceutically acceptable compositions, and methods for using them to prevent and/or treat anthrax and similar diseases comprising an agent that decreases the activity of caspase ΒΌ, such as YVAD, and/or an agent that increases the phosphorylation of AKT, such as IB-MECA or Cl-IB-MECA, together with, in particular embodiments, an antibiotic, such as ciprofloxacin. Kits comprising the same are provided as well, among other things.
    Type: Application
    Filed: March 6, 2008
    Publication date: February 24, 2011
    Applicant: George Mason Intellectual Properties Inc.
    Inventors: Serguei G. Popov, Taissia Popov, Virginia Espina, Charles Bailey, Lance A. Liotta, Emanuel Petricoin
  • Publication number: 20100298157
    Abstract: A subject's likelihood of responding to bariatric surgery can be assessed by measuring the phosphorylation state of certain proteins found in white adipose tissue (WAT). In particular, measuring the phosphorylation state of particular proteins can predict a patient's likelihood of resolving diabetes mellitus following bariatric surgery. In addition, evaluating the phosphorylation state of certain proteins forecasts a patient's capacity to reduce excess body weight and/or waist size following bariatric surgery. Such tests are valuable tools for managing the diseases of diabetes and obesity and determining who would most likely benefit from bariatric surgical procedures such as gastic bypass surgery.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 25, 2010
    Applicants: GEORGE MASON INTELLECTUAL PROPERTIES, INC., INOVA HEALTH CARE SERVICES
    Inventors: Emanuel Petricoin, III, Valerie Calvert, Zobair Younossi, Lance Liotta
  • Publication number: 20100240543
    Abstract: The current invention is a capture-particle comprising: a) a molecular sieve portion; and b) an analyte binding portion; wherein the molecular sieve portion, analyte binding portion or both further comprise a cross-linked region having modified porosity. Capture particles wherein the molecular sieve portion, analyte binding portion or both comprise pore dimensions sufficient to exclude molecules larger than about 60 kDa. These particles are useful in purification and diagnostic methods. Kits comprising the capture particles are also described.
    Type: Application
    Filed: September 27, 2006
    Publication date: September 23, 2010
    Inventors: Lance Liotta, Emanuel Petricoin, David Geho
  • Patent number: 7794952
    Abstract: The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: September 14, 2010
    Assignee: George Mason University
    Inventors: Lance Liotta, Emanuel Petricoin