Patents by Inventor Emil Kartalov
Emil Kartalov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10068051Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.Type: GrantFiled: August 5, 2014Date of Patent: September 4, 2018Assignee: California Institute of TechnologyInventors: Emil Kartalov, Aditya Rajagopal, Axel Scherer
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Patent number: 9340765Abstract: A method to suppress biofilm formation in a growth chamber of a chemostat is described. The method includes the steps of adding a lysis agent to an isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber. The microfluidic chemostat includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat also included a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber.Type: GrantFiled: March 26, 2013Date of Patent: May 17, 2016Assignee: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Patent number: 9212994Abstract: A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.Type: GrantFiled: January 11, 2012Date of Patent: December 15, 2015Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: George Maltezos, John Kim Lee, Axel Scherer, Emil Kartalov
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Publication number: 20150057178Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.Type: ApplicationFiled: August 5, 2014Publication date: February 26, 2015Inventors: Emil Kartalov, Aditya Rajagopal, Axel Scherer
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Patent number: 8838394Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.Type: GrantFiled: February 1, 2013Date of Patent: September 16, 2014Assignee: California Institute of TechnologyInventors: Emil Kartalov, Aditya Rajagopal, Axel Scherer
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Publication number: 20140141497Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: ApplicationFiled: March 26, 2013Publication date: May 22, 2014Applicant: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Publication number: 20130323716Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.Type: ApplicationFiled: February 1, 2013Publication date: December 5, 2013Applicant: California Institute of TechnologyInventors: Emil Kartalov, Aditya Rajagopal, Axel Scherer
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Patent number: 8426159Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: GrantFiled: August 3, 2011Date of Patent: April 23, 2013Assignee: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Publication number: 20120141337Abstract: A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.Type: ApplicationFiled: January 11, 2012Publication date: June 7, 2012Inventors: George Maltezos, John Kim Lee, Axel Scherer, Emil Kartalov
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Patent number: 8137626Abstract: Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.Type: GrantFiled: May 17, 2007Date of Patent: March 20, 2012Assignee: California Institute of TechnologyInventors: George Maltezos, John Kim Lee, Axel Scherer, Emil Kartalov
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Publication number: 20120065277Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: ApplicationFiled: August 3, 2011Publication date: March 15, 2012Applicant: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Patent number: 8017353Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: GrantFiled: July 29, 2008Date of Patent: September 13, 2011Assignee: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Patent number: 7992587Abstract: By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.Type: GrantFiled: November 28, 2006Date of Patent: August 9, 2011Assignee: California Institute of TechnologyInventors: Emil Kartalov, Axel Scherer, W. French Anderson, Christopher I. Walker
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Patent number: 7611673Abstract: Component microfluidic devices which are integrated with polydimethylsiloxane (PDMS) microfluidic chips, include designs for an electrical and optical pressure gauge, valve, electrostatic and magnetic pumps, alternating or mixing pumps, a solenoid, a magnetometer, a magnetically actuated reversible filter and valve, and a hydrolysis valve. These devices enhance and miniaturize microfluidic control, thereby expanding the available capabilities and allowing complete system miniaturization for handheld diagnostic apparatuses.Type: GrantFiled: September 28, 2006Date of Patent: November 3, 2009Assignee: California Institute of TechnologyInventors: Emil Kartalov, Axel Scherer, W. French Anderson
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Publication number: 20090242059Abstract: Component microfluidic devices which are integrated with polydimethylsiloxane (PDMS) microfluidic chips, include designs for an electrical and optical pressure gauge, valve, electrostatic and magnetic pumps, alternating or mixing pumps, a solenoid, a magnetometer, a magnetically actuated reversible filter and valve, and a hydrolysis valve. These devices enhance and miniaturize microfluidic control, thereby expanding the available capabilities and allowing complete system miniaturization for handheld diagnostic apparatuses.Type: ApplicationFiled: September 28, 2006Publication date: October 1, 2009Inventors: Emil Kartalov, Axel Scherer, W. French Anderson
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Publication number: 20090018195Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: ApplicationFiled: July 29, 2008Publication date: January 15, 2009Applicant: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Patent number: 7407799Abstract: A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.Type: GrantFiled: December 14, 2004Date of Patent: August 5, 2008Assignee: California Institute of TechnologyInventors: Frederick Balagadde, Carl L. Hansen, Emil Kartalov, Stephen R. Quake
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Publication number: 20080013092Abstract: Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.Type: ApplicationFiled: May 17, 2007Publication date: January 17, 2008Inventors: George Maltezos, John Lee, Axel Scherer, Emil Kartalov
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Patent number: 7297518Abstract: The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence microscopy to image polynucleotide molecules at single molecule resolution.Type: GrantFiled: March 12, 2002Date of Patent: November 20, 2007Assignee: California Institute of TechnologyInventors: Stephen Quake, Ido Braslavsky, Benedict Hebert, Emil Kartalov
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Publication number: 20070119510Abstract: By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.Type: ApplicationFiled: November 28, 2006Publication date: May 31, 2007Inventors: Emil Kartalov, Axel Scherer, W. Anderson