Patents by Inventor Emilio Barbera-Guillem

Emilio Barbera-Guillem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050079174
    Abstract: Methods are provided for reducing a pro-multiple sclerosis immune response by administering to an individual a composition comprising an affinity ligand which binds to B cell determinant, and which is administered in an amount effective to reduce B cells.
    Type: Application
    Filed: July 24, 2003
    Publication date: April 14, 2005
    Applicant: BioCrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, M. Nelson
  • Publication number: 20050019486
    Abstract: Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound thereto comprises contacting the functionalized encapsulated fluorescent nanocrystals with a sample so that complexes are formed between the functionalized encapsulated fluorescent nanocrystals and substrate for which the affinity molecule has binding specificity, if the substrate is present; exposing the complexes in the detection system to an excitation light source, and detecting a fluorescence peak emitted from the complexes, if present.
    Type: Application
    Filed: June 14, 2004
    Publication date: January 27, 2005
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6835326
    Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: December 28, 2004
    Assignee: BioCrystal, Ltd.
    Inventor: Emilio Barbera-Guillem
  • Publication number: 20040241424
    Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder.
    Type: Application
    Filed: July 2, 2004
    Publication date: December 2, 2004
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6821772
    Abstract: Provided is a cell culture apparatus for culturing cells, and optionally, for performing magnetic separation of cells desired to be cultured. The cell culture apparatus preferably comprises a frame; at least one gas permeable membrane securedly sealed in a leak-proof sealing to a frame and an opposing surface comprising a rigid surface in forming a culture chamber therebetween; and at least one resealable aperture to allow substances to be introduced into, or withdrawn from, the culture chamber.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: November 23, 2004
    Assignee: BioCrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, M. Bud Nelson
  • Patent number: 6811752
    Abstract: Provided is a device comprising a plurality of microchambers having a closed vented environment, wherein each microchamber is in operative communication with a filling port and a vent aperture. The device further comprises a base which is sandwiched between two liquid-impermeable membranes, with at least one of the membranes being gas permeable. Also provided is a method for introducing a fluid into a plurality of microchambers of the device, wherein each filling port is aligned with a pipette tip, and the fluid is introduced into and through the filling port. The fluid then flows along a fluid flow groove providing fluid flow communication between the filling port and the microchamber, and into the microchamber.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: November 2, 2004
    Assignee: BioCrystal, Ltd.
    Inventor: Emilio Barbera-Guillem
  • Publication number: 20040203170
    Abstract: An identifiable code pattern, a method of providing a carrier material with an identifiable code pattern, and a method for detecting an identifiable code pattern are based on applying water-soluble nanocrystals to carrier materials in a spatially arranged format that can be detected by exposing the identifiable code pattern to an excitation light source in exciting the water-soluble nanocrystals, and detecting any fluorescence peaks emitted from the excited water-soluble nanocrystals using a detection system.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 14, 2004
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6762032
    Abstract: Provided are methods, and assay kits, and compositions useful for generating an indicator of a disease condition selected from the group consisting of multiple sclerosis (MS), a pro-MS immune response, and a combination thereof. A method for assaying a sample of an individual for an indicator of the disease condition comprises contacting the sample with a combination of two or more affinity ligands, at least one of which comprises a detection reagent; measuring an amount of the detection reagent which is bound to the sample in determining a value of a marker in the sample; wherein a difference in the value of the marker determined in the sample, when compared to the reference value, comprises an indicator of the presence of the disease condition.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: July 13, 2004
    Assignee: BioCrystal, Ltd.
    Inventors: M. Bud Nelson, Emilio Barbera-Guillem
  • Patent number: 6761877
    Abstract: Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound thereto comprises contacting the functionalized encapsulated fluorescent nanocrystals with a sample so that complexes are formed between the functionalized encapsulated fluorescent nanocrystals and substrate for which the affinity molecule has binding specificity, if the substrate is present; exposing the complexes in the detection system to an excitation light source, and detecting a fluorescence peak emitted from the complexes, if present.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: July 13, 2004
    Assignee: BioCrystal, Ltd.
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6760612
    Abstract: A method is provided for detecting lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an individual, and detected in the individual is the presence of lymphoid tissue which contains shed tumor antigen, as detected by the signal emitted by the detector molecule bound to shed tumor antigen. The lymphoid tissue, detected as containing shed tumor antigen, may then be surgically removed, thereby removing B cells, shed tumor antigen, and follicular dendritic cells involved in a pro-tumor immune response that are contained in the removed lymphoid tissue.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: July 6, 2004
    Assignee: Phylatron Ltd.
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6749750
    Abstract: A magnetic sheet assembly for application to a device adapted for magnetic separation, the magnetic sheet assembly comprising: a magnetic sheet; a permanent, pressure sensitive adhesive; a carrier sheet; and a non-permanent pressure sensitive adhesive. Also provided is a method of mounting and removably adhering the magnetic sheet assembly to a surface of a device for magnetic separation, the method comprising the steps of aligning the magnetic sheet assembly with the surface of the device; and pressing the aligned magnetic sheet assembly in placing its non-permanent adhesive face into adhesive contact with the surface of the device.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: June 15, 2004
    Assignee: Biocrystal Ltd.
    Inventors: Emilio Barbera-Guillem, Marlin O. Thurston
  • Publication number: 20040029266
    Abstract: A cell culture device (100, 830) incorporating confronting planar anterior and posterior shells or walls (110, 140, 834, 836) that are joined about peripheral edges to define a media reservoir or cistern (170, 850). At least one of the shells and walls and edges is optionally formed with an aperture or respirator (180, 873). At least one fluid transfer port (220, 870) with a resealable elastomeric septum (230, 872) compatible for use with a small needle or needleless connector or pipetter tip (T, T′) is preferably formed in least one of the shells and walls (110, 140, 834, 836) and edges and that is in fluid communication with the media reservoir or cistern or chamber (170, 850). The device (100, 830) also includes at least one gas valvule (320, 875) that is formed in one or more of the shells and walls (110, 140, 834, 836) and edges and is in fluid communication with the media reservoir (170, 850) to vent gas from and supply gas to the reservoir (170, 850).
    Type: Application
    Filed: August 9, 2002
    Publication date: February 12, 2004
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6680211
    Abstract: Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of producing the fluorescent microspheres comprising swelling the polymeric microsphere so that into its pores can enter fluorescent nanocrystals, and then unswelling the polymeric micropsheres so that the fluorescent nanocrystals become physically entrapped in the pores of the unswelled polymeric microsphere. Also provided is a method of using the fluorescent microspheres comprising affinity ligand for determining the presence or absence of a predetermined number of analytes in a sample by contacting the sample with the fluorescent microspheres, and detecting the fluorescence signal pattern of excited fluorescent microspheres bound to one or more analytes of the predetermined number of analytes, if present in the sample.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: January 20, 2004
    Assignee: Biocrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, Stephanie L. Castro
  • Patent number: 6673595
    Abstract: An automated cell management system which can be programmed to perform and control various operations of the essential phases of cell culturing, of cell culture manipulation, and of cell culture evaluation. The automated cell management system comprises a housing, a storage array for accommodating a plurality of cell culture devices, a loading station, a means for harvesting one or more components from a cell culture device, and one or more processing stations. The automated cell management system may further comprise mechanism for tracking each cell culture device, a plurality of reservoirs, a centrifuge, a microprocessor, one or more evaluation stations, one or more means for sterilization, and a combination thereof.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 6, 2004
    Assignee: Biocrystal, LTD
    Inventor: Emilio Barbera-Guillem
  • Publication number: 20030212027
    Abstract: Provided are methods for inducing an immune response reactive with idiotypes on shed antigen-specific B cells in an individual by administering an immunologically effective amount of a vaccine formulation. Also provided are vaccine formulations comprising one or more peptides, wherein a peptide comprises an idiotype of an antibody that binds to an epitope of shed antigen; or one or more polynucleotides, wherein a polynucleotide encodes a peptide comprising an idiotype of an antibody that binds to an epitope of shed antigen.
    Type: Application
    Filed: January 3, 2003
    Publication date: November 13, 2003
    Applicant: BioCrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, M. Bud Nelson
  • Publication number: 20030177941
    Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder.
    Type: Application
    Filed: April 16, 2003
    Publication date: September 25, 2003
    Inventor: Emilio Barbera-Guillem
  • Publication number: 20030157327
    Abstract: Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of producing the fluorescent microspheres comprising swelling the polymeric microsphere so that into its pores can enter fluorescent nanocrystals, and then unswelling the polymeric micropsheres so that the fluorescent nanocrystals become physically entrapped in the pores of the unswelled polymeric microsphere. Also provided is a method of using the fluorescent microspheres comprising affinity ligand for determining the presence or absence of a predetermined number of analytes in a sample by contacting the sample with the fluorescent microspheres, and detecting the fluorescence signal pattern of excited fluorescent microspheres bound to one or more analytes of the predetermined number of analytes, if present in the sample.
    Type: Application
    Filed: February 14, 2003
    Publication date: August 21, 2003
    Inventors: Emilio Barbera-Guillem, Stephanie L. Castro
  • Publication number: 20030138859
    Abstract: Methods and assay kits are provided for assaying for a measurable biological response inducible by activation of Fc&ggr;RI-expressing cells by immune complexes comprising shed antigen and anti-shed antigen antibody of an IgG subtype capable of binding Fc&ggr;RI. An assay kit comprises shed antigen, anti-shed antigen antibody of an IgG subtype capable of binding Fc&ggr;RI, and Fc&ggr;RI-expressing cells.
    Type: Application
    Filed: November 7, 2002
    Publication date: July 24, 2003
    Applicant: BioCrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, M. Bud Nelson
  • Patent number: 6576155
    Abstract: A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: June 10, 2003
    Assignee: Biocrystal, Ltd.
    Inventor: Emilio Barbera-Guillem
  • Patent number: 6555365
    Abstract: Provided for heating cultured cells is a controlled heater device comprising a cell culture apparatus, a transparent heater in thermal contact with the cell culture apparatus, and may further comprise one or more of a transparent filter provided to prevent a predetermined spectral range of light from passing through the transparent filter, and a power source for controlling the amount of heat generated by the transparent heater of the controlled heater device.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: April 29, 2003
    Assignee: BioCrystal, Ltd.
    Inventors: Emilio Barbera-Guillem, Rick D. Lucas