Patents by Inventor Emily A. Reiff

Emily A. Reiff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates in the preparation of entecavir via carbon-silicon oxidation
    Patent number: 7968555
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for the Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation
    Publication number: 20100286089
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: July 22, 2010
    Publication date: November 11, 2010
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Patent number: 7786300
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 31, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation
    Publication number: 20090143578
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: February 4, 2009
    Publication date: June 4, 2009
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Patent number: 7511139
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: March 31, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Synthesis of a benzoxazinone
    Patent number: 7205402
    Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: April 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Purushotham Vemishetti, Scott T. Chadwick, Carrie A. Costello, Sridhar Desikan, Emily A. Reiff
  • Synthesis of a benzoxazinone
    Publication number: 20060047115
    Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
    Type: Application
    Filed: September 1, 2005
    Publication date: March 2, 2006
    Inventors: Purushotham Vemishetti, Scott Chadwick, Carrie Costello, Sridhar Desikan, Emily Reiff
  • Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Publication number: 20050272932
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 8, 2005
    Inventors: Maotang Zhou, Emily Reiff, Purushotham Vemishetti, Yadagiri Pendri, Ambarish Singh, Siva Prasad, Ulhas Dhokte, Xinhua Qian, Pia Mountford, Kerry Hartung, Helen Sailes
  • Synthesis of epothilones
    Patent number: 6603015
    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 5, 2003
    Assignee: University of Kansas
    Inventors: Gunda I. Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori
  • SYNTHESIS OF EPOTHILONES
    Publication number: 20020165415
    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment C using a stereoselective Noyori-type reduction, and the coupling of epothilone segments B and C using an aldol condensation reaction. The synthesis methods may be used to prepare naturally occurring segments as well as a large number of related analogs and homologs thereof. Final epothilones in accordance with the invention may also be of the naturally occurring variety (16-membered macrolides), while the homologs and analogs thereof are preferably up to 20-membered macrolides.
    Type: Application
    Filed: March 2, 2001
    Publication date: November 7, 2002
    Inventors: Gunda I. Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori, John T. Henri
  • Synthesis of epothilones
    Publication number: 20020156289
    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.
    Type: Application
    Filed: December 11, 2001
    Publication date: October 24, 2002
    Applicant: THE UNIVERSITY OF KANSAS
    Inventors: Gunda I. Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori
  • Synthesis of epothilones
    Patent number: 6457303
    Abstract: Various epothilone precursors needed for the preparation of final epothilones are provided.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: October 1, 2002
    Assignee: The University of Kansas
    Inventors: Gunda I Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori, John T. Henri
  • Synthesis of epothilones
    Patent number: 6211412
    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment C using a stereoselective Noyori-type reduction, and the coupling of epothilone segments B and C using an aldol condensation reaction. The synthesis methods may be used to prepare naturally occurring segments as well as a large number of related analogs and homologs thereof. Final epothilones in accordance with the invention may also be of the naturally occurring variety (16-membered macrolides), while the homologs and analogs thereof are preferably up to 20-membered macrolides.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 3, 2001
    Assignee: The University of Kansas
    Inventors: Gunda I. Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori, John T. Henri