Abstract: An equine therapy boot that has an insulating shaft that can be securely fastened at multiple locations on an equine leg and hold a volume of therapeutic media to treat the equine hoof and leg is disclosed herein. The equine therapy boot includes a sole member, an internal securing mechanism, and an insulating shaft configured to retain therapeutic media. Advantageously, this equine therapy boot secures the horse's hoof to the sole member such that the insulating shaft is not displaced from the horse's hoof and leg during the treatment period. Also disclosed herein are methods of treating a diseased or injured horse's hoof and leg with the disclosed equine therapy boot.