Patents by Inventor Emily Stern
Emily Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11630176Abstract: A system and method is provided for controlling physiological-noise in functional magnetic resonance imaging using raw k-space data to extract physiological noise effects. The method can identify these effects when they are separable and directly reflects the artefactual effects on fMRI data, without the need for external monitoring or recording devices and to be compensated for via rigorous statistical analysis modeling of such noise sources. The physiological fluctuations may be treated as global perturbations presented around the origin point in a k-space 2D slice. Each k-space 2D slice may be acquired at a very short repetition time with an effective sampling rate to sample cardiac and respiratory rhythms through proper reordering and phase-unwarping techniques applied to the raw k-space data.Type: GrantFiled: December 23, 2020Date of Patent: April 18, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: David Silbersweig, Emily Stern, Hong Pan, Qiang Chen
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Patent number: 11612322Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.Type: GrantFiled: October 3, 2018Date of Patent: March 28, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Emily Stern, David Silbersweig, Hong Pan
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Publication number: 20230023393Abstract: A system and method is provided for controlling physiological-noise in functional magnetic resonance imaging using raw k-space data to extract physiological noise effects. The method can identify these effects when they are separable and directly reflects the artefactual effects on fMRI data, without the need for external monitoring or recording devices and to be compensated for via rigorous statistical analysis modeling of such noise sources. The physiological fluctuations may be treated as global perturbations presented around the origin point in a k-space 2D slice. Each k-space 2D slice may be acquired at a very short repetition time with an effective sampling rate to sample cardiac and respiratory rhythms through proper reordering and phase-unwarping techniques applied to the raw k-space data.Type: ApplicationFiled: December 23, 2020Publication date: January 26, 2023Inventors: David SILBERSWEIG, Emily STERN, Hong PAN, Qiang CHEN
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Patent number: 11423428Abstract: A method for tracking and incentivizing wellness activity using a fitness tracking device includes; synchronizing, with at least one processor, the user wellness data corresponding to a time period from the fitness tracking device by receiving at least one communication from the fitness tracking device; in response to synchronizing the user wellness data, determining, with at least one processor, whether the user is a participating user; and in response to the determination that the user is a participating user, automatically communicating, with at least one processor, at least one activity message comprising the user wellness data of the user over the time period to at least one transaction processing server. Various other systems and methods for tracking and incentivizing wellness activity using a fitness tracking device are disclosed.Type: GrantFiled: August 11, 2017Date of Patent: August 23, 2022Assignee: Visa International Service AssociationInventors: Shweta Sitaram Naik, Emily Stern, Francine Merrill Grant, Uday Vashisht, Praveen Kumar Prathy, Seena Ganesh
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Publication number: 20200288980Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.Type: ApplicationFiled: October 3, 2018Publication date: September 17, 2020Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Emily Stern, David Silbersweig, Hong Pan
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Patent number: 10761173Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.Type: GrantFiled: April 8, 2019Date of Patent: September 1, 2020Assignee: The Brigham and Women's Hospital, Inc.Inventors: Emily Stern, David Silbersweig, Hong Pan, Yihong Yang, Hong Gu
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Publication number: 20200167815Abstract: A method for tracking and incentivizing wellness activity using a fitness tracking device includes; synchronizing, with at least one processor, the user wellness data corresponding to a time period from the fitness tracking device by receiving at least one communication from the fitness tracking device; in response to synchronizing the user wellness data, determining, with at least one processor, whether the user is a participating user; and in response to the determination that the user is a participating user, automatically communicating, with at least one processor, at least one activity message comprising the user wellness data of the user over the time period to at least one transaction processing server. Various other systems and methods for tracking and incentivizing wellness activity using a fitness tracking device are disclosed.Type: ApplicationFiled: August 11, 2017Publication date: May 28, 2020Inventors: Shweta Sitaram Naik, Emily Stern, Francine Merrill Grant, Uday Vashisht, Praveen Kumar Prathy, Seena Ganesh
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Patent number: 10586326Abstract: Systems and methods for generating biomarkers associated with neuropsychiatric disorders, neurodevelopmental disorders, neurobehavioral disorders, or other neurological disorders are described. In general, the biomarkers are generated based on correlations between functional imaging data and clinical acquired from a subject, as computed using a multivariate classifier. Functional imaging data may include functional magnetic resonance images, or activation maps generated from such images. Clinical data generally includes data associated with a clinical or behavioral characterization of the subject. The biomarkers can be used to monitor or otherwise assess a treatment response; to provide diagnostic information, such as subtyping or classifying a disorder; to provide prognostic information, such as a prediction of treatment response or outcome; or to indicate functional or anatomical targets for treatments.Type: GrantFiled: July 6, 2017Date of Patent: March 10, 2020Assignee: The Brigham and Women's Hospital, Inc.Inventors: David Silbersweig, Emily Stern, Hong Pan
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Publication number: 20200033434Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.Type: ApplicationFiled: April 8, 2019Publication date: January 30, 2020Inventors: Emily Stern, David Silbersweig, Hong Pan, Yihong Yang, Hong Gu
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Patent number: 10254371Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.Type: GrantFiled: August 28, 2014Date of Patent: April 9, 2019Assignee: Brigham and Women's Hospital, Inc.Inventors: Emily Stern, David Silbersweig, Hong Pan, Yihong Yang, Hong Gu
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Publication number: 20170309022Abstract: Systems and methods for generating biomarkers associated with neuropsychiatric disorders, neurodevelopmental disorders, neurobehavioral disorders, or other neurological disorders are described. In general, the biomarkers are generated based on correlations between functional imaging data and clinical acquired from a subject, as computed using a multivariate classifier. Functional imaging data may include functional magnetic resonance images, or activation maps generated from such images. Clinical data generally includes data associated with a clinical or behavioral characterization of the subject. The biomarkers can be used to monitor or otherwise assess a treatment response; to provide diagnostic information, such as subtyping or classifying a disorder; to provide prognostic information, such as a prediction of treatment response or outcome; or to indicate functional or anatomical targets for treatments.Type: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: David Silbersweig, Emily Stern, Hong Pan
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Patent number: 9773308Abstract: Systems and methods for generating biomarkers associated with neuropsychiatric disorders, neurodevelopmental disorders, neurobehavioral disorders, or other neurological disorders are described. In general, the biomarkers are generated based on correlations between functional imaging data and clinical acquired from a subject, as computed using a multivariate classifier. Functional imaging data may include functional magnetic resonance images, or activation maps generated from such images. Clinical data generally includes data associated with a clinical or behavioral characterization of the subject. The biomarkers can be used to monitor or otherwise assess a treatment response; to provide diagnostic information, such as subtyping or classifying a disorder; to provide prognostic information, such as a prediction of treatment response or outcome; or to indicate functional or anatomical targets for treatments.Type: GrantFiled: July 15, 2015Date of Patent: September 26, 2017Assignee: The Brigham and Women's HospitalInventors: David Silbersweig, Emily Stern, Hong Pan
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Publication number: 20160209487Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.Type: ApplicationFiled: August 28, 2014Publication date: July 21, 2016Inventors: Emily Stern, David Silbersweig, Hong Pan
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Publication number: 20160019693Abstract: Systems and methods for generating biomarkers associated with neuropsychiatric disorders, neurodevelopmental disorders, neurobehavioral disorders, or other neurological disorders are described. In general, the biomarkers are generated based on correlations between functional imaging data and clinical acquired from a subject, as computed using a multivariate classifier. Functional imaging data may include functional magnetic resonance images, or activation maps generated from such images. Clinical data generally includes data associated with a clinical or behavioral characterization of the subject. The biomarkers can be used to monitor or otherwise assess a treatment response; to provide diagnostic information, such as subtyping or classifying a disorder; to provide prognostic information, such as a prediction of treatment response or outcome; or to indicate functional or anatomical targets for treatments.Type: ApplicationFiled: July 15, 2015Publication date: January 21, 2016Inventors: David Silbersweig, Emily Stern, Hong Pan