Patents by Inventor Emmanuel Delamarche

Emmanuel Delamarche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160279632
    Abstract: A microfluidic device and method. A device includes one or more microchannels. Each microchannel comprising: a microchannel portion with a longitudinal liquid barrier that defines first and second regions. The device includes one or more first liquid passages at the level of the longitudinal barrier. A liquid inlet allows liquid to enter the first region and a liquid outlet allows liquid to leave the microchannel portion. A transverse liquid barrier between the microchannel portion and the liquid outlet holds liquid in the first region. The device includes one or more second liquid passages at the level of the transverse liquid barrier. A liquid pump displaces liquid through a microchannel portion. The first liquid passages allow excess liquid in the first region to flow into the second region, transversally to the longitudinal barrier. The second liquid passages allow excess liquid in the longitudinal portion to be discharged via the liquid outlet.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 29, 2016
    Inventors: Emmanuel Delamarche, Onur Gökce
  • Publication number: 20160271608
    Abstract: A microfluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti-wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
    Type: Application
    Filed: March 19, 2015
    Publication date: September 22, 2016
    Inventors: Emmanuel Delamarche, Yuksel Temiz
  • Publication number: 20160243549
    Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 25, 2016
    Inventors: JULIEN AUTEBERT, EMMANUEL DELAMARCHE, GOVIND KAIGALA, XANDER FRANK VAN KOOTEN
  • Patent number: 9421540
    Abstract: A microfluidic device is provided. The microfluidic device has: a flow inlet and a flow outlet; a bypass channel defining a first flow path away from the flow inlet and toward the flow outlet; and an auxiliary channel defining a second flow path away from the flow inlet and toward the flow outlet, wherein the auxiliary channel defines a reagent area adapted to receive a reagent, and wherein the auxiliary channel joins the bypass channel at a primary junction downstream from the reagent area and upstream from the flow outlet.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: August 23, 2016
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Luc Gervais, Martina Hitzbleck
  • Publication number: 20160236194
    Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 18, 2016
    Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
  • Publication number: 20160133517
    Abstract: The present invention is notably directed to a method of fabrication of a microfluidic chip (1). comprising: providing (S10-S20) a wafer (10, 12) of semiconductor material having a diamond cubic crystal structure, exhibiting two opposite main surfaces (S1, S2), one on each side of the wafer, and having, each, a normal in the <100> or <110> direction; and performing (S30) self-limited, anisotropic wet etching steps on each of the two main surfaces on each side of the wafer, to create a via (20, 20a) extending transversely through the thickness of the wafer, at a location such that the resulting via connects an in-plane microchannel (31) on a first one (51) of the two main surfaces to a second one (S2) of the two main surfaces, the via exhibiting slanted sidewalls (20s) as a result of the self-limited wet etching. The invention further concerns microfluidic chips accordingly obtained.
    Type: Application
    Filed: November 5, 2015
    Publication date: May 12, 2016
    Inventors: Emmanuel Delamarche, Bilge Eker, Yuksel Temiz
  • Patent number: 9229455
    Abstract: A microfluidic surface processing system includes a microfluidic probe head having a processing fluid circuit configured to dispense a surface processing fluid from a processing fluid aperture thereof; a linkage mechanism, configured to apply a force to or modulate a force applied to the microfluidic probe head towards a surface to be processed; and a lifting fluid circuit integral with the microfluidic probe head and distinct from the processing fluid circuit, the lifting fluid circuit designed for dispensing a lifting fluid from a lifting fluid aperture thereof, with pressure such as to counter the force applied or modulated by the linkage mechanism, at the level of the surface.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: January 5, 2016
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Martina Hitzbleck, Govind Kaigala, Robert Lovchik
  • Patent number: 9207684
    Abstract: A microfluidic surface processing system includes a microfluidic probe head having a processing fluid circuit configured to dispense a surface processing fluid from a processing fluid aperture thereof; a linkage mechanism, configured to apply a force to or modulate a force applied to the microfluidic probe head towards a surface to be processed; and a lifting fluid circuit integral with the microfluidic probe head and distinct from the processing fluid circuit, the lifting fluid circuit designed for dispensing a lifting fluid from a lifting fluid aperture thereof, with pressure such as to counter the force applied or modulated by the linkage mechanism, at the level of the surface.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: December 8, 2015
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Martina Hitzbleck, Govind Kaigala, Robert Lovchik
  • Patent number: 9205397
    Abstract: A microfluidic device with interconnects. The device includes a first layer; a second layer, the first layer and the second layer assembled such as to face each other; a microchannel in said second layer; a tapered conduit having a tapered portion, wherein the tapered portion is inserted in a correspondingly shaped via formed in the first layer at the level of an end of the microchannel such that fluid communication is enabled between the microchannel and the conduit, and blocked in the via by way of the assembled first layer and second layer.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: December 8, 2015
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Govind Kaigala, Robert Lovchik
  • Patent number: 9168521
    Abstract: A microfluidic device includes a first microchannel, a second microchannel, and a valve comprising at least an input port and an output port, the ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid along a flow direction (z) defined by the ports; wherein the valve further comprises one or more walls joining the ports and defining a hollow chamber that is wider than each of the microchannels in a direction perpendicular to the flow direction, the walls at least partly deformable along a deformation direction (?y) intersecting the flow direction, such that the walls can be given at least a first deformation state and a second deformation state, such that the liquid can be pulled along the flow direction substantially more in the second deformation state than in the first deformation state.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: October 27, 2015
    Assignees: International Business Machines Corporation, CORIS BIOCONCEPT
    Inventors: Emmanuel Delamarche, Martina Hitzbleck, Laetitia C. Avrain, Thierry C. Laurent, Pascal Y. Mertens, Valerie Smekens
  • Patent number: 9110056
    Abstract: A biosensor comprising surface treated with a method for producing a monolayer of molecules on a surface, the method comprising loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, wherein transferring comprises transferring a fraction of the seed molecules loaded on the stamp to the surface and adsorbing the seed molecules to the stamp and adsorbing the seed molecules to the surface, the adsorption of the seed molecules to the stamp being stronger than the adsorption of the seed molecules to the surface, self-completing amplification of the seed molecules via an amplifying reaction to produce the monolayer on a flat surface, wherein self-completing amplification comprises producing a homogeneous area, wherein the homogeneous area comprises a monolayer of molecules on the surface, and wherein the monolayer of molecules on the surface has no diffusive component that can relocate and destroy amplification accuracy.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: August 18, 2015
    Assignee: International Business Machines Corporation
    Inventors: Sergey Amontov, Emmanuel Delamarche, Bruno Michel
  • Publication number: 20150198596
    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.
    Type: Application
    Filed: March 26, 2015
    Publication date: July 16, 2015
    Inventors: Emmanuel Delamarche, Daniel J. Solis
  • Patent number: 9012136
    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: April 21, 2015
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Daniel J. Solis
  • Patent number: 9005887
    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: April 14, 2015
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Daniel J. Solis
  • Patent number: 8961905
    Abstract: An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 24, 2015
    Assignee: Lenovo Enterprise Solutions (Singapore) Pte. Ltd.
    Inventors: Govindarajan Natarajan, Emmanuel Delamarche, Eric A. Eckberg, James N. Humenik, Kathleen A. McGroddy-Goetz, Scott Partington, Christopher F. Perrera, Marco G. Trivella, Timothy M. Wiwel
  • Patent number: 8951612
    Abstract: A method for processing a surface involves depositing at least one class of enzymes (2) onto the surface (1); introducing at least a reactant (3) into an environment of the surface (1), and causing interaction between the enzymes (2) and the reactant (3), thereby to cause processing of a region of the surface (1), the processed region of the surface (1) being defined with respect to a region thereof that is proximate (4) to where the enzymes (3) have been deposited.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: February 10, 2015
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Matthias Geissler
  • Publication number: 20140137962
    Abstract: A microfluidic surface processing system includes a microfluidic probe head having a processing fluid circuit configured to dispense a surface processing fluid from a processing fluid aperture thereof; a linkage mechanism, configured to apply a force to or modulate a force applied to the microfluidic probe head towards a surface to be processed; and a lifting fluid circuit integral with the microfluidic probe head and distinct from the processing fluid circuit, the lifting fluid circuit designed for dispensing a lifting fluid from a lifting fluid aperture thereof, with pressure such as to counter the force applied or modulated by the linkage mechanism, at the level of the surface.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 22, 2014
    Applicant: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Martina Hitzbleck, Govind Kaigala, Robert Lovchik
  • Patent number: 8695641
    Abstract: A microfluidic probe head includes a first layer, a second layer, and a first tubing port extending from an upper face of the first layer. The first layer has a first via, enabling fluid communication between the first port and a lower face of the first layer. The second layer includes a first aperture on a face, and a first microchannel enabling fluid communication between an upper face of the second layer, facing the lower face of the first layer, and the first aperture. The head enables fluid communication between the first via and the first microchannel. At least a portion of the first microchannel is a groove open on the upper face of the second layer, closed by a portion of a lower face of a layer of the head. The probe head further comprises a second tubing port, a second via, a second aperture and a second microchannel.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: April 15, 2014
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Ute Drechsler, Robert Lovchik
  • Patent number: 8695639
    Abstract: A micro fluidic probe head includes a first layer, a second layer, and a first tubing port extending from an upper face of the first layer. The first layer has a first via, enabling fluid communication between the first port and a lower face of the first layer. The second layer includes a first aperture on a face, and a first microchannel enabling fluid communication between an upper face of the second layer, facing the lower face of the first layer, and the first aperture. The head enables fluid communication between the first via and the first microchannel. At least a portion of the first microchannel is a groove open on the upper face of the second layer, closed by a portion of a lower face of a layer of the head. The probe head further comprises a second tubing port, a second via, a second aperture and a second micro channel.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: April 15, 2014
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Ute Drechsler, Robert Lovchik
  • Publication number: 20140090715
    Abstract: A microfluidic surface processing system includes a microfluidic probe head having a processing fluid circuit configured to dispense a surface processing fluid from a processing fluid aperture thereof; a linkage mechanism, configured to apply a force to or modulate a force applied to the microfluidic probe head towards a surface to be processed; and a lifting fluid circuit integral with the microfluidic probe head and distinct from the processing fluid circuit, the lifting fluid circuit designed for dispensing a lifting fluid from a lifting fluid aperture thereof, with pressure such as to counter the force applied or modulated by the linkage mechanism, at the level of the surface.
    Type: Application
    Filed: September 12, 2013
    Publication date: April 3, 2014
    Applicant: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, Martina Hitzbleck, Govind Kaigala, Robert Lovchik