Patents by Inventor Emmanuel Skordalakes

Emmanuel Skordalakes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160067257
    Abstract: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 10, 2016
    Applicant: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Patent number: 9234230
    Abstract: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: January 12, 2016
    Assignee: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Patent number: 8518940
    Abstract: The present invention embraces compounds selected for interacting with the Fingers-Palm pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: August 27, 2013
    Assignee: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Patent number: 8377992
    Abstract: The present invention embraces compounds selected for interacting with the T-pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: February 19, 2013
    Assignee: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Patent number: 8374838
    Abstract: The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain of telomerase and testing the compound for its ability to modulate the activity of telomerase.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: February 12, 2013
    Assignee: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Publication number: 20120309759
    Abstract: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
    Type: Application
    Filed: February 8, 2011
    Publication date: December 6, 2012
    Applicant: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Patent number: 8234080
    Abstract: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: July 31, 2012
    Assignee: The Wistar Institute
    Inventor: Emmanuel Skordalakes
  • Publication number: 20100248280
    Abstract: The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain of telomerase and testing the compound for its ability to modulate the activity of telomerase.
    Type: Application
    Filed: October 21, 2008
    Publication date: September 30, 2010
    Inventor: Emmanuel Skordalakes
  • Publication number: 20100216150
    Abstract: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 26, 2010
    Inventor: Emmanuel Skordalakes
  • Publication number: 20100158798
    Abstract: The present invention embraces compounds selected for interacting with the Fingers-Palm pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
    Type: Application
    Filed: February 8, 2010
    Publication date: June 24, 2010
    Inventor: Emmanuel Skordalakes
  • Publication number: 20100160260
    Abstract: The present invention embraces compounds selected for interacting with the T-pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
    Type: Application
    Filed: February 8, 2010
    Publication date: June 24, 2010
    Inventor: Emmanuel Skordalakes