Patents by Inventor Endrene Magyari

Endrene Magyari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Industrial process for the synthesis of 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
    Patent number: 8110691
    Abstract: A new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 7, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Lajosné Dancsi, György Visky, Zoltán Tuba, János Csörgei, Csaba Molnár, Endréné Magyari
  • Process for the synthesis of high purity -(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
    Patent number: 7816546
    Abstract: The invention relates to a process for the synthesis of d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: October 19, 2010
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, János Kiss, Endréné Magyari, László Terdy
  • INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17alpha-ACETOXY-11beta-[4-(N,N-DIMETHYL-AMINO)-PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS
    Publication number: 20090187032
    Abstract: The present invention relates to a new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Application
    Filed: May 18, 2007
    Publication date: July 23, 2009
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Lajosne Dancsi, Gyorgy Visky, Zoltan Tuba, Janos Csorgei, Csaba Molnar, Endrene Magyari
  • Process for the synthesis of high purity D-(17a)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one oxime
    Publication number: 20050032763
    Abstract: The invention relates to a process for the synthesis of d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
    Type: Application
    Filed: June 30, 2004
    Publication date: February 10, 2005
    Inventors: Zoltan Tuba, Sandor Maho, Janos Kiss, Endrene Magyari, Laszlo Terdy