Patents by Inventor Ennio Tasciotti

Ennio Tasciotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210338593
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Publication number: 20200392462
    Abstract: Methods of inducing cardiomyocytes from induced pluripotent stem cells by contacting induced pluripotent stem cells with silica nanoparticles comprising regulators of canonical Wnt signaling and coated with a biodegradable polymer.
    Type: Application
    Filed: January 29, 2019
    Publication date: December 17, 2020
    Inventors: Christopher J. Tsao, Ennio Tasciotti, Jeffrey Jacot, Francesca Taraballi
  • Publication number: 20190167589
    Abstract: Disclosed are biomimetic proteolipid nanovesicles that possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types. In particular embodiments, drug delivery vehicles are provided composed of synthetic phospholipids and cholesterol, enriched of leukocyte membranes, and surrounding an aqueous core. These nanovesicles are able to both avoid the immune system, thanks to the presence on their surface of self-tolerance proteins, as CD-45, CD-47, and MHC-1, and target inflamed endothelium, thereby diffusing in the tumor microenvironment. These properties make the composition highly suited for targeted drug delivery to mammalian tumor cells in vitro and in situ.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 6, 2019
    Inventors: Ennio Tasciotti, Roberto Molinaro
  • Publication number: 20190151510
    Abstract: Disclosed are trilaminate collagen-based tissue scaffolds that exhibit remarkable morphological mimicry to that of the natural mammalian periosteum tissue they are useful in remodeling. In particular embodiments, periosteum-modeling trizonal membranes for reforming and regrowing human bone tissue are provided that are composed of a first zone of compact collagen, a second layer of collagen-elastin, and a third layer of biomineralized collagen.
    Type: Application
    Filed: August 22, 2018
    Publication date: May 23, 2019
    Inventors: Ennio Tasciotti, Francesca Taraballi, Silvia Minardi
  • Publication number: 20190117572
    Abstract: Disclosed are methods for designing and manufacturing biomimetic proteolipid nanovesicles using a microfluidic approach, and in particular, a NanoAssemblr®-based platform, which allows for the high-throughput, reproducible, and scalable production of nanoparticles, without affecting their pharmaceutical and biological properties. These nanovesicles, which are composed of synthetic phospholipids and cholesterol, enriched of leukocyte membranes, and surrounding an aqueous core, possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types.
    Type: Application
    Filed: March 7, 2018
    Publication date: April 25, 2019
    Inventors: Ennio Tasciotti, Roberto Molinaro
  • Publication number: 20190111000
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10206781
    Abstract: The present invention relates to a polymer scaffold design and method for treating segmental long bone defects without amputation that permits permanent regrowth of bone in the area of the segmental defect, without external fixation or other problems inherent in current systems. The polymer scaffold is preferably made from a poly(ester urea) polymer and includes an outer shell, sized to fit over a segmental defect in a bone, and a collagen containing material. In some embodiments, the collagen containing material is placed in a polymer insert sized to fit within the segmental bone defect and within said outer shell. In some embodiments, the outer shell may contain struts running longitudinal struts along the inside surface of the outer shell. In some of these embodiments, the insert will have a corresponding set of grooves sized to receive the struts.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: February 19, 2019
    Assignees: The University of Akron, Houston Methodist Hospital
    Inventors: Matthew Becker, Ennio Tasciotti, Bradley Weiner, Avraam Isayev
  • Publication number: 20190001025
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 3, 2019
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20180361032
    Abstract: Disclosed are biocompatible, biodegradable, implantable devices for the controlled release of bioactive molecules. In particular embodiments, nanotechnology-based tunable implants are disclosed for 1) localized delivery of analgesics to treat postoperative pain; 2) sustained delivery of growth factors to promote vascularization; and 3) directing tissue regeneration, including the self-direction of autologous stem cells for organ remodeling.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Ennio Tasciotti, Francesca Taraballi, Silvia Minardi
  • Publication number: 20180361030
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Patent number: 10143658
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 4, 2018
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10058633
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: August 28, 2018
    Assignee: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20170136154
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: September 20, 2016
    Publication date: May 18, 2017
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20170086978
    Abstract: The present invention relates to a polymer scaffold design and method for treating segmental long bone defects without amputation that permits permanent regrowth of bone in the area of the segmental defect, without external fixation or other problems inherent in current systems. The polymer scaffold is preferably made from a poly(ester urea) polymer and includes an outer shell, sized to fit over a segmental defect in a bone, and a collagen containing material. In some embodiments, the collagen containing material is placed in a polymer insert sized to fit within the segmental bone defect and within said outer shell. In some embodiments, the outer shell may contain struts running longitudinal struts along the inside surface of the outer shell. In some of these embodiments, the insert will have a corresponding set of grooves sized to receive the struts.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 30, 2017
    Applicants: The University of Akron, Houston Methodist Hospital
    Inventors: Matthew Becker, Ennio Tasciotti, Bradley Weiner, Avraam Isayev
  • Publication number: 20160051481
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: May 29, 2015
    Publication date: February 25, 2016
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 8685755
    Abstract: A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 ?l in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: April 1, 2014
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Mauro Ferrari, Xuewu Liu, Ennio Tasciotti, Ali Bouamrani, Ye Hu
  • Publication number: 20130184835
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: March 24, 2011
    Publication date: July 18, 2013
    Applicant: Board of Regents of the Unversity of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20130071329
    Abstract: The present invention pertains to therapeutic compositions and delivery systems comprising at least one microparticle or nanoparticle. In various embodiments, the surface of the microparticle or nanoparticle is modified or functionalized with at least a portion of an isolated cellular membrane, such as an isolated plasma membrane. In addition, the microparticle or nanoparticle contains at least one active agent, such as a therapeutic and/or imaging agent. In additional embodiments, the compositions and delivery systems of the present invention may be used for targeted delivery of an active agent. Also provided are methods of making the therapeutic compositions and delivery systems of the present invention.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 21, 2013
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Ennio Tasciotti, Nicoletta Quattrocchi
  • Publication number: 20130071326
    Abstract: The present invention provides modified stem cells that comprise a delivery system that comprises at least one microparticle or nanoparticle, wherein the at least one microparticle or nanoparticle comprises an active agent. The present invention also provides delivery methods that comprise the administration of the modified stem cells to a subject. Additional aspects of the present invention pertain to methods of making said modified stem cells.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 21, 2013
    Applicant: Board of Regents of the University of Texas System
    Inventors: Jonathan O. Martinez, Ennio Tasciotti, Mikhail Kolonin, Mauro Ferrari
  • Publication number: 20110065207
    Abstract: A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 ?l in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples.
    Type: Application
    Filed: July 20, 2010
    Publication date: March 17, 2011
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Xuewu Liu, Ennio Tasciotti, Ali Bouamrani, Ye Hu