Patents by Inventor Eric Garver

Eric Garver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030032788
    Abstract: The invention includes methods for reducing alcohol consumption in mammals by inhibiting expression of an aldehyde dehydrogenase (e.g., liver mitochondrial aldehyde dehydrogenase) in cells of the mammal. Expression of the aldehyde dehydrogenase can be inhibited by administering (locally or systemically) an antisense oligonucleotide (e.g., one 12-2000 residues in length) to the mammal, whereby expression of a relatively active allele of an aldehyde dehydrogenase gene can be inhibited. Aldehyde dehydrogenase activity can also be inhibited in the cells of a mammal, for the same purposes, by administering to the cells an expression vector encoding an inactive allele dominant of the aldehyde dehydrogenase. Upon expression, subunits of the protein encoded by the inactive allele can coalesce with one another or with subunits of the cells normally-expressed aldehyde dehydrogenase to lower the level of aldehyde dehydrogenase activity in the cell.
    Type: Application
    Filed: August 17, 2001
    Publication date: February 13, 2003
    Applicant: Thomas Jefferson University
    Inventors: Eric Garver, Guang-Chou Tu, Yedy Israel