Abstract: The present disclosure relates to systems and methods for low-power, data transmission using ultrasound signals. In one implementation, a data transmission system includes an ultrasound transducer configured to generate ultrasound signals in response to power supplied from a power source, and a mechanical ultrasound amplifier coupled to the ultrasound transducer, the ultrasound amplifier having a substrate adapted to function as a soundboard to amplify the ultrasound signals. The range of the data transmission system may be increased with a relay system. The relay system may include one or more detectors and one or more repeaters.

Abstract: A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface.

Abstract: Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

Abstract: A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

Abstract: Compact devices are provided to measure hematocrit of a blood sample. These devices include first and second chambers that receive respective portions of a blood sample via respective filters. The material of the filters prevents passage of red blood cells while permitting passage of blood plasma. One of the filters has one or more holes to permit the passage of whole blood. Thus, when an example device is presented with a sample of blood, one of the chambers contains whole blood and the other contains blood from which the red blood cells have been filtered. Electrodes in each of the chambers can then be used to detect the impedances of the whole blood and the filtered blood, and the detected impedances can be used to determine a hematocrit of the sample of blood.

Abstract: Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.

Abstract: A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Abstract: A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

Abstract: A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Abstract: A method for pairing a key fob with a control unit is provided. The key fob executes an ID authenticated key agreement protocol with a pairing device based on a key fob identification to authenticate one another and to generate a first encryption key. The pairing device encrypts a control unit identification using the first encryption key. The key fob receives the encrypted control unit identification transmitted from the pairing device. The key fob then executes an ID authenticated key agreement protocol with the control unit based on the control unit identification to authenticate one another and to generate a second encryption key. The key fob then receives an operational key transmitted from the control unit that is encrypted with the second encryption key.

Abstract: Methods and systems are provided for measuring the flow of fluid (e.g., blood) in vasculature of a human by heating the fluid in a portion of the vasculature and detecting the temperature of fluid in and/or tissue proximate to a downstream portion of the vasculature. The blood is heated by emitting energy through an external body surface into the portion of vasculature. The temperature of the downstream portion of vasculature is detected by an infrared sensor receiving infrared light from the body and/or a temperature sensor in thermally conductive contact with the body. The flow of fluid in the portion of vasculature can be determined by determining a latency between a change in the detected temperature relative to a change in the emitted energy, by determining a difference between the detected temperature and a detected temperature of another portion of the body, or by some other method.

Abstract: Devices are provided to automatically access blood from beneath or within skin. These devices include an injector configured to drive a needle into the skin and subsequently to retract the needle from the skin. These devices additionally include a seal to which suction is applied. To drive the needle into the skin, the needle is first driven through the seal, creating at least one hole in the seal. The suction applied to the seal acts to draw blood from the puncture formed in the skin by the needle, through the at least one hole in the seal, and to a sensor, blood storage element, or other payload. These devices can be wearable and configured to automatically access blood from skin, for example, to access blood from the skin at one or more points in time while a wearer of a device is sleeping.

Abstract: An electronic device, in disclosed embodiments, includes an antenna, transceiver circuitry coupled to the antenna, a memory configured to store a first operation key and instructions, and a processor coupled to the transceiver and to the memory. The processor is configured to execute the instructions stored in the memory to cause the electronic device to, in response to receiving a first transmission containing an encrypted version of a second operation key that is encrypted by the first operation key, decrypt the encrypted version of the second operation key using the first operation key to recover the second operation key, store the second operation key in the memory, transmitting, by a transmitter of the electronic device, a second transmission that contains the first operation key and a command.

Abstract: A method for pairing a key fob with a control unit is provided. The key fob executes an ID authenticated key agreement protocol with a pairing device based on a key fob identification to authenticate one another and to generate a first encryption key. The pairing device encrypts a control unit identification using the first encryption key. The key fob receives the encrypted control unit identification transmitted from the pairing device. The key fob then executes an ID authenticated key agreement protocol with the control unit based on the control unit identification to authenticate one another and to generate a second encryption key. The key fob then receives an operational key transmitted from the control unit that is encrypted with the second encryption key.

Abstract: Embodiments described herein may relate to an unmanned aerial vehicle (UAV) navigating to a target in order to provide medical support. An illustrative method involves a UAV (a) determining an approximate target location associated with a target, (b) using a first navigation process to navigate the UAV to the approximate target location, where the first navigation process generates flight-control signals based on the approximate target location, (c) making a determination that the UAV is located at the approximate target location, and (d) in response to the determination that the UAV is located at the approximate target location, using a second navigation process to navigate the UAV to the target, wherein the second navigation process generates flight-control signals based on real-time localization of the target.

Abstract: Devices are provided to automatically access blood from beneath or within skin. These devices include an injector configured to drive a needle into the skin and subsequently to retract the needle from the skin. These devices additionally include a seal to which suction is applied. To drive the needle into the skin, the needle is first driven through the seal, creating at least one hole in the seal. The suction applied to the seal acts to draw blood from the puncture formed in the skin by the needle, through the at least one hole in the seal, and to a sensor, blood storage element, or other payload. These devices can be wearable and configured to automatically access blood from skin, for example, to access blood from the skin at one or more points in time while a wearer of a device is sleeping.

Abstract: A dampening fluid useful in offset ink printing applications contains water and a surfactant whose structure can be altered. The alteration in structure aids in reducing accumulation of the surfactant on the surface of an imaging member. The surfactant can be decomposed, switched between cis-trans states, or polymerizable with ink that is subsequently placed on the surface.

Abstract: A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Abstract: A control unit, in a disclosed embodiment, includes a transceiver, memory, and a processor. The processor is coupled to the transceiver and memory and executes instructions from the memory to cause the control unit to receive a first transmission containing a certificate, verify the authenticity of the certificate, and, after verifying authenticity of the certificate, execute a public key agreement protocol to generate a first common secret encryption key, receive a second transmission containing an encrypted first public key that is encrypted by the first common secret encryption key, decrypt the encrypted first public key using the first common secret encryption key to determine the first public key, execute a public key agreement protocol to generate a second common secret encryption key, generate an operational key, encrypt the operational key using the second common secret encryption key, and transmit the encrypted operational key.

Abstract: A camera attachment apparatus for attaching to a mobile computing device having an integrated camera includes a house, a slide plate, an aperture, and an illumination system. The housing has a shape to mount on the mobile computing device. The slide plate is disposed within the housing and has a stowed position and a deployed position. The aperture is disposed in the slide plate. The illumination system is disposed on the slide plate. The slide plate is configured to align the aperture over the integrated camera when moved to the deployed position and does not obstruct the integrated camera in the stowed position.