Patents by Inventor Ernest CARRA

Ernest CARRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9708342
    Abstract: The present invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl) carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3] oxazepin-8-olate Form I and the therapeutic uses thereof.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 18, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Ernest A. Carra, Irene Chen, Vahid Zia
  • Patent number: 9708327
    Abstract: Polymorphs of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed. Solvent forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are also disclosed.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 18, 2017
    Assignee: GILEAD CALISTOGA LLC
    Inventors: Suzanne Buttar, Ernest Carra, Tracy Ehiwe, Duong Tran, Fang Wang, Christopher Worrall, Jerry Evarts
  • Publication number: 20170197985
    Abstract: The present Invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10 ((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5] pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 13, 2017
    Inventors: Ernest A. Carra, Irene Chen, Vahid Zia
  • Patent number: 9682084
    Abstract: The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 20, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Ernest A. Carra, Irene Chen, Katie Ann Keaton, Scott E. Lazerwith, Vahid Zia
  • Patent number: 9643956
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide(Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 9, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya Smolenskaya, Lok Him Yu
  • Publication number: 20160376274
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 29, 2016
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry Evarts
  • Publication number: 20160347719
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Application
    Filed: August 8, 2016
    Publication date: December 1, 2016
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Patent number: 9469643
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: October 18, 2016
    Assignee: Gilead Calistoga, LLC.
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry B. Evarts
  • Patent number: 9469613
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 18, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Publication number: 20160280683
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Application
    Filed: December 22, 2015
    Publication date: September 29, 2016
    Applicant: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Valeriya Smolenskaya, Lok Him Yu
  • Publication number: 20160016973
    Abstract: The present invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
    Type: Application
    Filed: June 19, 2015
    Publication date: January 21, 2016
    Inventors: Ernest A. Carra, Irene Chen, Vahid Zia
  • Publication number: 20150366872
    Abstract: The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Inventors: Ernest A. Carra, Irene Chen, Katie Ann Keaton, Vahid Zia
  • Publication number: 20150361050
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Application
    Filed: June 11, 2015
    Publication date: December 17, 2015
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Publication number: 20150175606
    Abstract: Polymorphs of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed. Solvent forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are also disclosed.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Suzanne Buttar, Ernest Carra, Tracy Ehiwe, Duong Tran, Fang Wang, Christopher Worrall
  • Publication number: 20150080572
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 19, 2015
    Applicant: GILEAD CALISTOGA LLC
    Inventors: Ernest CARRA, Michael GERBER, Bing SHI, Keiko SUJINO, Duong TRAN, Fang WANG, Jerry B. EVARTS
  • Patent number: 8865730
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: October 21, 2014
    Assignee: Gilead Calistoga LLC
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry B. Evarts
  • Publication number: 20130252976
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Applicant: GILEAD CALISTOGA LLC
    Inventors: Ernest CARRA, Michael GERBER, Bing SHI, Keiko SUJINO, Duong TRAN, Fang WANG
  • Patent number: 3937859
    Abstract: A new and improved resin composition having both thermoplastic and thermosetting properties and suitable for use for coating fabrics to produce fusible interlinings. The resin composition consists of a terpolymer having the following formula: ##EQU1## where R is selected from the group consisting of ethylene, propylene and butylene, a and b are substantially equal, a plus b equals 20c, X is a radical selected from the group consisting of CONH.sub.2 and COOH and n is an integer from 100 to 300. The composition also contains an aminoplast.
    Type: Grant
    Filed: April 12, 1974
    Date of Patent: February 10, 1976
    Assignee: Johnson & Johnson
    Inventors: Mark Ernest Carra, Louis Albert Manrique, Jr.