Patents by Inventor Ernest-Guenter Afting

Ernest-Guenter Afting has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide plasminogen activators
    Patent number: 5501853
    Abstract: Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: March 26, 1996
    Assignees: Chiron Corporation, Behringwerke AG
    Inventors: Nancy L. Haigwood, Ernest-Guenter Afting, Guy Mullenbach, Eric P. Paques
  • Peptide plasminogen activators
    Patent number: 5439679
    Abstract: Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified.The plasmids designated 1, 2 and 3 were deposited at the A.T.C.C. on Dec. 20, 1985 and given A.T.C.C. designations 40214, 40215 and 40216, respectively.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 8, 1995
    Assignees: Chiron Corporation, Behringwerke AG
    Inventors: Ernest-Guenter Afting, Eric-Paul Paques, Nancy L. Haigwood, Guy Mullenbach