Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the looking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releaseably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releaseably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

Abstract: A device for delivering an occlusive element includes an elongate sheath. A distal blocking member is located at the distal end of the elongate sheath and includes an aperture therein. An elongate releasing member is disposed within a lumen of the elongate sheath. The elongate releasing member includes a proximal end and a distal end with the distal end terminating in at least one retaining member. The device includes an occlusive element such as, for example, a vaso-occlusive coil that has a securing member located at a proximal end thereof. The securing member of the occlusive element passes through the aperture of the distal blocking member and the at least one retaining member is releasably secured to the securing member.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the looking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releasably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the locking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

Abstract: Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices.

Abstract: Electrolytically detachable implantable devices and methods of delivering the same to a treatment site. An assembly includes an implantable device, such as a vaso-occlusive coil, a conductive deployment mechanism, such as a conductive pusher or wire, and a temporary connection between the deployment mechanism and the coil in the form of an electrolytically detachable junction. The detachable junction includes fine wires, e.g., stainless steel wires having a small diameter of about 0.00001? to about 0.0025?, for example, about 0.0005?. The pusher or wire is used to deliver the implantable device through a catheter and to a desired location or treatment site. After the implantable device is properly positioned, electrical current is applied to the fine wires, thereby simultaneously disintegrating the fine wires and leaving the coil at the treatment site.

Abstract: A device for delivering an occlusive element such as a vaso-occlusive coil includes an elongate sheath. An elongate releasing member having a distal tip or end is moveable within a lumen of the elongate sheath. A filament is provided having first and second ends with each end being fixed relative to the elongate sheath to form a loop segment. The loop segment of the filament is passed through a securing member located on the proximal end of the occlusive element. The distal tip of the elongate releasing member is inserted into the portion of the loop segment that passes through the securing member to lock the occlusive element relative to the elongate sheath. The occlusive element is released by pulling the elongate releasing member proximally to retract the distal tip from the loop segment of the filament.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the locking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releasably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

Abstract: A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.

Abstract: A system and method for delivering a presentation electronically. The invention takes advantage of the multiple monitor capabilities of a computer operating system to display a “control panel” on the computer monitor or laptop screen that typically only the presenter will view. The presenter can use this control panel to view and control the presentation while the audience only sees a full screen slideshow. Providing this “presenter” view and control makes computer-based presenting much easier. The presenter can control the specific aspects of the slideshow from the private monitor using control buttons or keyboard shortcuts.

Abstract: The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.

Abstract: The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient.

Abstract: A targeted vector allowing enhanced gene transfer to human hepato-cellular carcinoma (HCC1) cells in vitro was developed using cationic liposomes covalently conjugated with the mAb AF-20. This high affinity antibody recognizes a rapidly internalized 180 kDa cell surface glycoprotein which is abundantly expressed on the surface of human HCC and other cancer cells. Quantitative binding analysis of liposomes with target cells by flow cytometry showed specific association of mAb-targeted liposomes with human HCC cells. Using mAb-targeted cationic liposomes containing 20% DOTAP, in the presence or absence of serum, gene expression in HuH-7 cells was enhanced up to 40-fold as compared to liposomes conjugated with an isotype-matched non-relevant control antibody. Transfection specificity was not observed in a control cell line that does not express the antigen recognized by mAb AF-20.

Abstract: Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices.

Abstract: The present invention relates to gene transfer and gene therapy technology. More specifically, the invention provides compositions and methods for targeted virus delivery. The method utilizes a method of mixing the virus, which may be a recombinant virus which will express a protein of interest or a nucleic acid of interest, with a cell-targeting ligand, e.g., transferrin. The virus and ligand are mixed without crosslinkers or agents which would covalently bond the virus and ligand. This simple mixing causes less inactivation than chemically linking the ligand to the virus and therefore results in a more active therapeutic composition than obtained by methods which utilize crosslinking agents.

Abstract: The invention relates to a specific modified oligonucleotide complementary to a section of the human Ha-ras gene and mRNA, and its use to specifically regulate, modulate or inhibit expression of the HA-ras gene, and its use as a pharmaceutical for the treatment of conditions arising from the abnormal expression of the Ha-Ras gene, in particular in combination with chemotherapy and radiotherapy.