Patents by Inventor Eszter Dezseri

Eszter Dezseri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4490378
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl,R.sup.4 is other than ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 25, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor cs, Csaba Szantay, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Zsuzsanna Relle nee Somfa, Janos Sugar
  • Patent number: 4410459
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a -CH.sub.2 -O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl,provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl, R.sup.4 is other than ethyl.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: October 18, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor Acs, Csaba Szantay, Zsuzsanna Relle nee Somfai, Janos Sugar
  • Patent number: 4279816
    Abstract: New leurosine derivatives of the general formula (1), ##STR1## wherein R stands for hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt.
    Type: Grant
    Filed: February 5, 1975
    Date of Patent: July 21, 1981
    Assignee: Richter Gedeon Vegyszeti Gyar Rt.
    Inventors: Karola Jovanovics, Kalman Szasz, Bela Kellner, Laszlo Nemeth, Zsuzsa Relle, Emil Bittner, Eszter Dezseri, Janos Eles
  • Patent number: 4199505
    Abstract: A process for the preparation of alkaloids of the leurosine type having the formula I ##STR1## and the acid addition salts thereof. In the formula I R is hydrogen or methyl. The compounds prepared according to the invention are known compounds showing cytostatic activity.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: April 22, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Katalin Nogradi, Karola Jovanovics, Eszter Dezseri, Lajos Dancsi, Csaba Lorincz, Bela Szarvady, Lajos Kovacs
  • Patent number: 4189432
    Abstract: Leurosine derivatives of the formula (I), ##STR1## wherein R is hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt. The new compounds of the invention possess strong cytostatic activity, and can be used in the human therapy with great advantage.
    Type: Grant
    Filed: December 5, 1973
    Date of Patent: February 19, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Karola Jovanovics, Kalman Szasz, Bela Kellner, Laszlo Nemeth, Zsuzsa Relle, Emil Bittner, Eszter Dezseri, Janos Eles
  • Patent number: 4172077
    Abstract: Tumor inhibiting alkaloids are recovered from Vinca Rosea L. by a method which comprises extracting the dried leaves with a solvent selected from the group consisting of an alkanol having 1 to 5 carbon atoms, a mixture of an alkanol having 1 to 5 carbon atoms and a dilute, aqueous solution, benzene and benzene homologs; subsequently purifying the alkaloid extract obtained by a phase-change method between immiscible solvents, precipitating the main amount of dimeric alkaloids in form of their sulphuric acid addition salts, isolating leurosine, vincistine, vinblastine, desacetoxy-vinblastine, N-desmethyl-vinblastine and desacetyl-vinblastine from the salt mixture obtained, and then completing the separation and isolation of the remaining alkaloids by separation and isolation by adjusting the pH-value of the mother liquor, after precipitation and removal of the salt mixture, to 5.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: October 23, 1979
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Karola Jovanovics, Gyorgy Fekete, Eszter Dezseri, Lajos Dancsi, Csaba Lorincz, Bela Szarvady, Gyorgy Dobo, Csaba Szantay, Lajos Szabo
  • Patent number: 4070358
    Abstract: A process is disclosed for the separation and recovery of vinblastine and leurosine from a mixture of diindole alkaloids obtained by extraction of the plant, Vinca rosea L.
    Type: Grant
    Filed: October 22, 1976
    Date of Patent: January 24, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Karola Jovanovics, Kalman Szasz, Csaba Lorincz, Laszlo Hermann, Eszter Dezseri