Patents by Inventor Etsuo Nakamura

Etsuo Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11136411
    Abstract: Provided is a humanized monoclonal antibody or an antibody fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 5, 2021
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Shoichi Naito, Hiroaki Aino, Etsuo Nakamura, Sunao Imai, Shoji Yamane
  • Publication number: 20210221876
    Abstract: Objective of the present invention is to provide a novel monoclonal antibody against Nav1.7. The present invention discloses a monoclonal antibody against Nav1.7 or its antibody fragment, having specific six CDRs (CDR1 to CDR3 of a heavy chain and CDR1 to CDR3 of a light chain) or specific heavy/light chain variable regions. The monoclonal antibody and the like can be used for treating or preventing pain, pruritus and so on.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 22, 2021
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Tatsuya TAKAHASHI, Mai YOSHIKAWA, Sosuke YONEDA, Junji ONODA, Etsuo NAKAMURA, Tsuguo MIYAUCHI, Toshiyuki ASAKI, Erika KASAI
  • Publication number: 20200071424
    Abstract: Provided is a humanized monoclonal antibody or an antibody fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 5, 2020
    Applicant: Shionogi & Co., Ltd.
    Inventors: Shoichi NAITO, Hiroaki AINO, Etsuo NAKAMURA, Sunao IMAI, Shoji YAMANE
  • Patent number: 10570215
    Abstract: Provided is a humanized monoclonal antibody or an antibody fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 25, 2020
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Shoichi Naito, Hiroaki Aino, Etsuo Nakamura, Sunao Imai, Shoji Yamane
  • Publication number: 20170260290
    Abstract: Provided is a humanized monoclonal antibody or an antibody fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Application
    Filed: March 10, 2017
    Publication date: September 14, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Shoichi NAITO, Hiroaki AINO, Etsuo NAKAMURA, Sunao IMAI, Shoji YAMANE
  • Patent number: 5665586
    Abstract: According to the present invention, a novel protease derived from Streptomyces fradiae for cleaving the C-terminal of a glutamic acid residue in an amino acid sequence of a polypeptide and a production method for this protease from Streptomyces fradiae are provided, and the characteristics of this protease are made clear. Further, DNA sequences for encoding this protease and a prepropeptide are also made clear. The protease specific to glutamic acid can be used for a variety of purposes including analysis of a protein and cleavage of a peptide chain at a desired site in a fusion protein.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: September 9, 1997
    Assignee: Shionogi & Co., Ltd.
    Inventors: Etsuo Nakamura, Hiroshige Tsuzuki, Kengo Kitadokoro, Masaru Shin, Hiroshi Teraoka
  • Patent number: 5459064
    Abstract: A novel protease derived from Bacillus licheniformis is provided. The protease cleaves the peptide bonds at the carboxyl termini of glutamic acid residues in polypeptides. The protease contains an amino acid sequence from serine in the +1 position to glutamine in the +222 position of SEQ ID NO: 1.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: October 17, 1995
    Assignee: Shionogi & Co., Ltd.
    Inventors: Hiroshi Teraoka, Mikio Tamaki, Etsuo Nakamura, Masaru Shin, Nobuo Yoshida, Hiroshige Tsuzuki, Takashi Fujiwara, Koichi Matsumoto