Patents by Inventor Eveline Catharina Anna Clasina DEN BIEZEN

Eveline Catharina Anna Clasina DEN BIEZEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PCR METHOD AND KIT FOR DETERMINING PATHWAY ACTIVITY
    Publication number: 20230416820
    Abstract: The present invention relates to assemblies of primers and probes for determining the cellular signalling pathway of the AR pathway and optionally the activities of the pathways ER, PI3K-FOXO, MAPK-AP1, Notch, HH, TGFbeta, JAK-STAT1/2 and NFkB. Kit or use of the set of 3 or more primers and probes to determine the expression levels of 3 or more genes of the AR cellular signalling pathway and optionally from a cellular signalling pathway selected from the ER, PI3K-FOXO, MAPK-AP1, Notch, HH, TGFbeta, WNT, PR, NFkB, JAK-STAT1/2 and JAK-STAT3 pathways wherein the expression levels of three or more of the reference genes selected from: ACTB, ALAS1, B2M, EEF1A1, POLR2A, PUM1, RPLPO, TBP, TPT1 and TUBA1B may also be determined.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 28, 2023
    Applicant: InnoSIGN B.V.
    Inventors: Eveline Catharina Anna Clasina DEN BIEZEN, Dianne Arnoldina Margaretha Wilhelmina VAN STRIJP, Anne Godefrida Catharina VAN BRUSSEL, Janneke WROBEL, Laurentius Henricus Franciscus Maria HOLTZER
  • System for applying a reagent to a sample
    Patent number: 11185863
    Abstract: In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 30, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Matthias Irmscher, Toon Hendrik Evers, Stefan Johannes Hendrikus Toonen, Marlieke Joan Overdijk, Harma Martine Feitsma, Thomas Johannes Van Gijsel, Wilbert Hendrik Bouwman, Eveline Catharina Anna Clasina Den Biezen-Timmermans, Willem-Jan Arend De Wijs
  • RISK SCORES BASED ON HUMAN PHOSPHODIESTERASE 4 D VARIANT 7 EXPRESSION
    Publication number: 20210277479
    Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
    Type: Application
    Filed: November 28, 2017
    Publication date: September 9, 2021
    Inventors: Ralf HOFFMAN, Dianne Arnoldina Margaretha Wilhelmina VAN STRIJP, Anne Godefrida Catharina VAN BRUSSEL, Janneke WROBEL, Johannes Baptist Adrianus Dionisius VAN ZON, Eveline Catharina Anna Clasina DEN BIEZEN, Márcia ALVES DE INDA
  • SYSTE FOR APPLYING A REAGENT TO A SAMPLE
    Publication number: 20190344263
    Abstract: In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.
    Type: Application
    Filed: September 29, 2017
    Publication date: November 14, 2019
    Inventors: Matthias IRMSCHER, Toon Hendrik EVERS, Stefan Johannes Hendrikus TOONEN, Marlieke Joan OVERDIJK, Harma Martine FEITSMA, Thomas Johannes VAN GIJSEL, Wilbert Hendrik BOUWMAN, Eveline Catharina Anna Clasina DEN BIEZEN-TIMMERMANS, Willem-Jan Arend DE WIJS