Patents by Inventor Evgeni A. Kabotyanski

Evgeni A. Kabotyanski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8828209
    Abstract: This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is capable of sequencing DNA sizes ranging from fragments to mammalian size genomes having mouse draft quality at a much reduced cost. The system comprises a massive parallel capillary electrophoretic separation using two-dimensional monolith multi-capillary arrays (2D-MMCA). Sequence identification can be performed using fluorescent or otherwise labeled dideoxynucleotide-terminated DNA extension product generated by gel matrix-, or beads-, or substrate tethered-, or otherwise immobilized colonies of single template molecules.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: September 9, 2014
    Assignee: The Research Foundation for the State University of New York
    Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski, Boris Gorbovitski
  • Patent number: 8231844
    Abstract: The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: July 31, 2012
    Assignee: The Research Foundation Of State University Of New York
    Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski
  • Publication number: 20120152742
    Abstract: This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is capable of sequencing DNA sizes ranging from fragments to mammalian size genomes having mouse draft quality at a much reduced cost. The system comprises a massive parallel capillary electrophoretic separation using two-dimensional monolith multi-capillary arrays (2D-MMCA). Sequence identification can be performed using fluorescent or otherwise labeled dideoxynucleotide-terminated DNA extension product generated by gel matrix-, or beads-, or substrate tethered-, or otherwise immobilized colonies of single template molecules.
    Type: Application
    Filed: June 22, 2006
    Publication date: June 21, 2012
    Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski, Boris Gorbovitski
  • Publication number: 20090071833
    Abstract: The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis.
    Type: Application
    Filed: October 22, 2007
    Publication date: March 19, 2009
    Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski