Patents by Inventor Evgenia Mandrusov

Evgenia Mandrusov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9101689
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: August 11, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Publication number: 20150216563
    Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
    Type: Application
    Filed: February 9, 2015
    Publication date: August 6, 2015
    Inventors: Evgenia Mandrusov, Albert K. Chin, William Earl Webler, JR., Yan Shen, Robert D. Ainsworth, Eugene Michal
  • Patent number: 8968991
    Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: March 3, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Evgenia Mandrusov, Albert K. Chin, William Earl Webler, Jr., Yan Shen, Robert D. Alnsworth, Eugene Michal
  • Patent number: 8858975
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: October 14, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Patent number: 8821473
    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: September 2, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyaz Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
  • Publication number: 20140199377
    Abstract: Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
    Type: Application
    Filed: March 18, 2014
    Publication date: July 17, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: John J. Stankus, Florian N. Ludwig, Evgenia Mandrusov, Liangxuan Zhang, Hong Ma, Jinping Wan, Shubhayu Basu
  • Patent number: 8747385
    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: June 10, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
  • Patent number: 8708948
    Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 29, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Paul Consigny, Gabriel Asongwe, Mary Beth Michaels, Gene Michal, Evgenia Mandrusov, Jeong Lee, Florian N. Ludwig, John Eric Henckel, Joseph J. Sciacca, Ken Bueche, Richard Todd Thornton, Fidel Albert Urrabazo, Daniel Wiegand
  • Patent number: 8703180
    Abstract: Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: April 22, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: John J. Stankus, Florian N. Ludwig, Evgenia Mandrusov, Liangxuan Zhang, Hong Ma, Jinping Wan, Shubhayu Basu
  • Patent number: 8652501
    Abstract: Primer coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The primer coatings can include a material with a high content of hydrogen bonding groups, such as some types of epoxy polymers and melamine formaldehydes. Coatings subsequently disposed over the primer coating can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: February 18, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Patent number: 8608661
    Abstract: A method including positioning a delivery device at a location in a blood vessel; advancing the delivery device a distance into a wall of the blood vessel to a treatment site beyond an external elastic lamina of the blood vessel; and after advancing the delivery device, introducing a treatment agent including a cellular component through the delivery device. A composition including a treatment agent comprising a cellular component associated with a matrix material, wherein the composition is suitable for percutaneous delivery. Also an apparatus suitable for delivering a treatment agent. Also, a kit including a treatment agent.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: December 17, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Evgenia Mandrusov, Eugene T. Michal
  • Patent number: 8608760
    Abstract: Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: December 17, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Gerald G. Fuller, Michael T. Longaker, Jayakumar Rajadas, Gordon Saul, C. Travis Rappleye, Evgenia Mandrusov
  • Patent number: 8521259
    Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: August 27, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Evgenia Mandrusov, Murthy V. Simhambhatla, Syed Hossainy, Eugene T. Michal, Charles Claude, Jessica G. Chiu
  • Patent number: 8383158
    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: February 26, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
  • Patent number: 8383142
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: February 26, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Patent number: 8337874
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: December 25, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Publication number: 20120219521
    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 30, 2012
    Applicant: Abbott Cardiovascular System Inc.
    Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatia, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
  • Publication number: 20120185034
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can serve as a primer coating for subsequent coatings that can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Inventors: Syed F.A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Patent number: 8211457
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: July 3, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Patent number: 8206733
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: June 26, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov