Patents by Inventor F. Raymond Salemme

F. Raymond Salemme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10542926
    Abstract: Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: January 28, 2020
    Assignee: OPERTECH BIO, INC.
    Inventors: R. Kyle Palmer, F. Raymond Salemme
  • Publication number: 20190038207
    Abstract: Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.
    Type: Application
    Filed: August 20, 2018
    Publication date: February 7, 2019
    Inventors: R. Kyle Palmer, F. Raymond Salemme
  • Patent number: 10052058
    Abstract: Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 21, 2018
    Assignee: OPERTECH BIO, INC.
    Inventors: R. Kyle Palmer, F. Raymond Salemme
  • Patent number: 9285363
    Abstract: A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: March 15, 2016
    Assignee: IMIPLEX LLC
    Inventors: F. Raymond Salemme, Patricia C. Weber
  • Patent number: 9102526
    Abstract: Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavidin or streptavidin-incorporating struts to produce structures with defined dimensions and geometry. Nanostructure assemblies having utility as functional devices or as resists for the patterning of substrates have architectures including polygons, polyhedra, two-dimensional lattices, and three-dimensional lattices.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: August 11, 2015
    Assignee: IMIPLEX LLC
    Inventors: F. Raymond Salemme, Patricia C. Weber, Mark A. Rould
  • Publication number: 20150064328
    Abstract: The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.
    Type: Application
    Filed: October 31, 2014
    Publication date: March 5, 2015
    Inventors: F. Raymond Salemme, Daniel Long, Roy Kyle Palmer, Francis Xavier Brennan, Dennis Sprous
  • Publication number: 20150064117
    Abstract: Embodiments of this invention encompass a method for producing and purifying rebaudioside C. In particular, this invention relates to a method for purifying rebaudioside C compositions to obtain a substantially pure rebaudioside C product using one or more crystallization steps. Resulting polymorphic forms of rebaudioside C, substantially pure rebaudioside C compositions and their uses are disclosed.
    Type: Application
    Filed: October 31, 2014
    Publication date: March 5, 2015
    Applicant: Redpoint Bio Corporation
    Inventors: F. Raymond Salemme, Robert A. Daines
  • Patent number: 8820265
    Abstract: Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 2, 2014
    Assignee: Opertech Bio, Inc.
    Inventors: R. Kyle Palmer, F. Raymond Salemme
  • Patent number: 8691879
    Abstract: The present invention is directed to the use of one or more rebaudioside C polymorphs, or stereoisomers thereof, to enhance the sweet taste of a flavoring, such as glucosylated steviol glycoside, rebaudioside A, ammoniated glycyrrhizin, neohespherdin dihydrochalcone or thaumatin.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 8, 2014
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Kenneth J. Kraut, Debra Merritt, F. Raymond Salemme
  • Publication number: 20140093633
    Abstract: The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: Redpoint Bio Corporation
    Inventors: F. Raymond Salemme, Daniel Long, Roy Kyle Palmer, Francis Xavier Brennan, Dennis Sprous
  • Patent number: 8609069
    Abstract: The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: December 17, 2013
    Assignee: Redpoint Bio Corporation
    Inventors: F. Raymond Salemme, Daniel Long, Roy Kyle Palmer, Francis Xavier Brennan, Dennis Sprous
  • Publication number: 20120230922
    Abstract: Embodiments of this invention encompass a method for producing and purifying rebaudioside C. In particular, this invention relates to a method for purifying rebaudioside C compositions to obtain a substantially pure rebaudioside C product using one or more crystallization steps. Resulting polymorphic forms of rebaudioside C, substantially pure rebaudioside C compositions and their uses are disclosed.
    Type: Application
    Filed: September 22, 2010
    Publication date: September 13, 2012
    Applicant: Redpoint Bio Corporation
    Inventors: F. Raymond Salemme, Robert A. Daines
  • Publication number: 20120164083
    Abstract: The present invention is directed to the use of rebaudioside A or rebaudioside D in combination with one or more compounds of Formula (I), or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables which include a combination of a carbohydrate sweetener, rebaudioside A or rebaudioside D, and one or more compounds of Formula (I), or a stereoisomer thereof.
    Type: Application
    Filed: August 31, 2010
    Publication date: June 28, 2012
    Applicant: Redpoint Bio Corporation
    Inventors: R. Kyle Palmer, F. Raymond Salemme
  • Patent number: 8193168
    Abstract: The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: June 5, 2012
    Assignee: Redpoint Bio Corporation
    Inventors: S. Paul Lee, Peihong Zhou, M. N. Tulu Buber, Rok Cerne, Robert Bryant, F. Raymond Salemme, Gillian Morgan
  • Publication number: 20120059156
    Abstract: A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.
    Type: Application
    Filed: May 10, 2010
    Publication date: March 8, 2012
    Inventors: F. Raymond Salemme, Patricia C. Weber
  • Publication number: 20110224311
    Abstract: The present invention is directed to the use of a compound of Formula I, or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and a compound of Formula I, or a stereoisomer thereof.
    Type: Application
    Filed: July 16, 2010
    Publication date: September 15, 2011
    Inventors: R. Kyle Palmer, F. Raymond Salemme, Dennis Sprous
  • Publication number: 20110085939
    Abstract: Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavidin or streptavidin-incorporating struts to produce structures with defined dimensions and geometry. Nanostructure assemblies having utility as functional devices or as resists for the patterning of substrates have architectures including polygons, polyhedra, two-dimensional lattices, and three-dimensional lattices.
    Type: Application
    Filed: September 28, 2010
    Publication date: April 14, 2011
    Applicant: IMIPLEX LLC
    Inventors: F. Raymond Salemme, Patricia C. Weber, Mark A. Rould
  • Publication number: 20110070172
    Abstract: The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.
    Type: Application
    Filed: May 18, 2010
    Publication date: March 24, 2011
    Inventors: F. Raymond SALEMME, Daniel Long, Roy Kyle Palmer, Francis Xavier Brennan, Dennis Sprous
  • Publication number: 20080306030
    Abstract: The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
    Type: Application
    Filed: February 4, 2008
    Publication date: December 11, 2008
    Applicant: Redpoint Bio Corporation
    Inventors: S. Paul Lee, Peihong Zhou, M.N. Tulu Buber, Rok Cerne, Robert Bryant, F. Raymond Salemme, Gillian Morgan
  • Patent number: 7039621
    Abstract: A method and computer product is presented for mapping n-dimensional input patterns into an m-dimensional space so as to preserve relationships that may exist in the n-dimensional space. A subset of the input patterns is chosen and mapped into the m-dimensional space using an iterative nonlinear mapping process. A set of locally defined neural networks is created, then trained in accordance with the mapping produced by the iterative process. Additional input patterns not in the subset are mapped into the m-dimensional space by using one of the local neural networks. In an alternative embodiment, the local neural networks are only used after training and use of a global neural network. The global neural network is trained in accordance with the mapping produced by the iterative process. Input patterns are initially projected into the m-dimensional space using the global neural network. Local neural networks are then used to refine the results of the global network.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: May 2, 2006
    Assignee: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
    Inventors: Dimitris K. Agrafiotis, Dmitri N. Rassokhin, Victor S. Lobanov, F. Raymond Salemme