Patents by Inventor Fabio MORANA

Fabio MORANA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process For Preparing SHP2 Inhibitors
    Publication number: 20250034160
    Abstract: Provided herein are methods for preparing a SHP2 inhibitor and intermediates useful therein.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 30, 2025
    Applicant: Genzyme Corporation
    Inventors: Fabio Morana, Davide Gornati, Jacopo Roletto
  • NOVEL PROCESS FOR PREPARING SOLRIAMFETOL HYDROCHLORIDE
    Publication number: 20230391715
    Abstract: The present invention concerns a novel process for preparing solriamfetol hydrochloride.
    Type: Application
    Filed: October 19, 2021
    Publication date: December 7, 2023
    Inventors: Davide Gornati, Fabio Morana, Jacopo Roletto, Paolo Paissoni
  • NEW PROCESS FOR PREPARING SUGAMMADEX
    Publication number: 20220194977
    Abstract: The present invention relates to a new process for preparing Sugammadex.
    Type: Application
    Filed: April 23, 2020
    Publication date: June 23, 2022
    Applicant: PROCOS S.P.A.
    Inventors: Fabio Morana, Jacopo Roletto, Paolo Paissoni
  • Process for the preparation of the crystalline form III of tipiracil hydrochloride
    Patent number: 11344550
    Abstract: The present invention concerns a process for the preparation of the crystalline form III of Tipiracil hydrochloride having a content of residual solvents lower than the ICH limits. Said process is advantageous with respect to the known processes because it allows the production of the form III of Tipiracil hydrochloride suitable for use in the preparation of pharmaceutical finished products.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 31, 2022
    Assignee: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Lucia Cozzi, Jacopo Roletto, Paolo Paissoni
  • Process for the synthesis of 6-chloromethyluracil
    Patent number: 11028057
    Abstract: The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: June 8, 2021
    Assignee: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE SYNTHESIS OF 6-CHLOROMETHYLURACIL
    Publication number: 20200407330
    Abstract: The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
    Type: Application
    Filed: February 13, 2019
    Publication date: December 31, 2020
    Applicant: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE PREPARATION OF THE CRYSTALLINE FORM III OF TIPIRACIL HYDROCHLORIDE
    Publication number: 20200330465
    Abstract: The present invention concerns a process for the preparation of the crystalline form III of Tipiracil hydrochloride having a content of residual solvents lower than the ICH limits. Said process is advantageous with respect to the known processes because it allows the production of the form III of Tipiracil hydrochloride suitable for use in the preparation of pharmaceutical finished products.
    Type: Application
    Filed: October 23, 2018
    Publication date: October 22, 2020
    Applicant: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Lucia Cozzi, Jacopo Roletto, Paolo Paissoni
  • Racemic beta-aminosulfone compounds
    Patent number: 10689332
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 23, 2020
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines
    Patent number: 10597353
    Abstract: The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: March 24, 2020
    Assignee: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe Barreca, Marcello Rasparini, Luca Carcone, Fabio Morana
  • RACEMIC BETA-AMINOSULFONE COMPOUNDS
    Publication number: 20200087254
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Application
    Filed: March 28, 2018
    Publication date: March 19, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • PROCESSES FOR THE PREPARATION OF DIASTEREOMERICALLY AND ENANTIOMERICALLY ENRICHED OXAZOLINES
    Publication number: 20180327349
    Abstract: The invention relates to an industrially viable and advantageous process for the preparation of (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof.
    Type: Application
    Filed: November 10, 2016
    Publication date: November 15, 2018
    Inventors: Giuseppe BARRECA, Marcello RASPARINI, Luca CARCONE, Fabio MORANA