Abstract: The present invention relates to methods to use cyclohexan-1,2-dione (CHD) groups to attach labels, linkers, and other molecules to a target compound comprising a CHD-reactive group such as a guanidine, amidine, urea, thiourea and the like. Methods of the invention include milder conditions than those previously known for promoting reaction of CHD with CHD-reactive groups, which makes the methods suitable for use with base-sensitive compounds and complex biomolecules. Methods of the invention are especially useful for attaching linking and labeling groups to a peptide that comprises at least one arginine residue, and can also be used to link such peptides to other target molecules such as nucleic acids. The invention also provides CHD-containing conjugation reagents and compositions comprising CHD-containing intermediates, and precursors useful for making CHD-containing compounds that can be used in the methods of the invention.

Abstract: A leakage management assembly for an orifice configured to limit a flow of at least one of a leakage fluid and a cooling fluid past an instrument positioned within the orifice are provided. The leakage management assembly includes a labyrinth ferrule including an annular ferrule body having a central bore extending therethrough. The labyrinth ferrule further includes an annular assembly cone formed at a first end of the labyrinth ferrule. The annular assembly cone includes an annular convergent lip and is configured to facilitate directing the instrument into the central bore. The labyrinth ferrule also includes a plurality of labyrinthine annular restrictions extending from a radially inner surface of the annular body toward the central bore. A combustor and a gas turbine engine including such a seal assembly are also provided.

Abstract: The disclosure provides an electric drill comprising: a housing; a motor for driving the electric drill to work; an output assembly for outputting the power of the motor; a first brake assembly including a driving disc and a driven disc respectively arranged on the transmission shaft and the output shaft, the driving disc being meshed with the driven disc to transmit power in a non-braking state, and the driving disc and the driven disc being displaced in the axial direction to be separated from each other in a braking state to stop transmitting power; and a second brake assembly including a mass block and a micro switch connected with the motor, and in a braking state, the mass block displacing and triggering the micro switch to stop the motor.

Abstract: The disclosure provides an earth auger comprising a supporting assembly, a drill pipe assembly including a drill pipe, a driving assembly arranged on the supporting assembly to drive the drill pipe assembly to work and a brake assembly including a trigger component that brakes the driving assembly and a brake lever connected through a first pivot and matched with the trigger component. The projection part of the brake lever on the plane perpendicular to the axis of the drill pipe is located outside the projection of the supporting assembly on the plane perpendicular to the axis of the drill pipe. The earth auger provided by the disclosure can effectively prevent accidents and improve the safety performance of the earth auger.

Abstract: A scan shift circuit and its driving method, a touch shift circuit and its driving method, a gate driving circuit, a touch driving circuit and a display apparatus are disclosed. The scan shift circuit includes an input circuit, a reset circuit, a latch control circuit and a scan signal output circuit. The touch shift circuit includes an input circuit, a reset circuit, a latch control circuit, a cascade signal output circuit, a touch driving circuit and a touch signal output circuit.

Abstract: Disclosed are redox flow battery membranes, redox flow batteries incorporating the membranes, and methods of forming the membranes. The membranes include a polybenzimidazole gel membrane that is capable of incorporating a high liquid content without loss of structure that is formed according to a process that includes in situ hydrolysis of a polyphosphoric acid solvent. The membranes are imbibed with a redox flow battery supporting electrolyte such as sulfuric acid and can operate at very high ionic conductivities of about 100 mS/cm or greater. Redox flow batteries incorporating the PBI-based membranes can operate at high current densities of about 100 mA/cm2 or greater.

Abstract: A shift register unit and a driving method thereof, a gate driving circuit and a display apparatus are provided. The shift register unit comprises: an input circuit, a transmission circuit and an output control circuit; wherein the transmission circuit is coupled to a first node, a second node, a clock signal terminal and a first power source terminal, respectively, and is configured to control an electric potential of the second node under the control of the first node, the clock signal terminal and the first power source terminal, and the output control circuit is configured to control an electric potential of the output signal terminal under the control of the second node. The electric potential of the output signal from the output signal terminal in the shift register unit can be controlled by adopting one clock signal terminal, which effectively reduces the power consumption of the shift register unit.

Abstract: Combustion sections and sealing systems for fuel ignition assemblies of gas turbine engine combustion sections are provided. For example, a sealing system comprises a ferrule positioned on an outer surface of a ceramic matrix composite (CMC) combustor liner an aperture defined in the CMC liner; a sleeve positioned within an adapter of the fuel ignition assembly such that an inner end portion of the sleeve is in contact with the ferrule, the sleeve having an end wall that forms an inner boundary of a cavity defined by the sleeve; and a biasing member positioned within the cavity. The biasing member extends between a bushing and the end wall of the sleeve. The biasing member continuously urges the sleeve into contact with the ferrule to seal the aperture against fluid leakage therethrough. The exemplary sealing system may be part of a fuel ignition assembly of a gas turbine engine combustion section.

Abstract: The present disclosure provides a polymer represented by the following general formula (I): wherein x and y each represent a repeating unit, and both x and y are positive integers; formula and formula are each independently selected from the group consisting of an aryl containing 5-40 ring atoms and a heteroaryl containing 5-40 ring atoms; formula is a linking group, and formula is selected from the group consisting of alkyl, alkoxy, amino, alkenyl, alkynyl, aralkyl, and heteroalkyl; and R2, R3 and R4 are each independently selected from the group consisting of H, D, F, CN, alkyl, fluoroalkyl, aryl, heteroaryl, amino, Si, germyl, alkoxy, aryloxy, fluoroalkoxy, siloxane, siloxy, deuterated alkyl, deuterated fluoroalkyl, deuterated aryl, deuterated heteroaryl, deuterated amino, deuterated silyl, deuterated germyl, deuterated alkoxy, deuterated aryloxy, deuterated fluoroalkoxy, deuterated siloxane, and deuterated siloxy.

Abstract: The present invention relates to a combination treatment for hematological cancers. More specifically; a combination of a telomerase inhibitor and a Bcl-2 inhibitor are useful in treating hematological cancers, including AML. In certain embodiments, the telomerase inhibitor is imetelstat or imetelstat sodium and the Bcl-2 inhibitor is ABT-199.

Abstract: A novel process for making PBI films starting from gel PBI membranes polymerized and casted in the PPA process wherein acid-imbibed gel PBIs are neutralized in a series of water baths and undergo controlled drying in association with a substrate material, yielding a PBI film without the use of organic solvents.

Abstract: A leakage management assembly for an orifice configured to limit a flow of at least one of a leakage fluid and a cooling fluid past an instrument positioned within the orifice are provided. The leakage management assembly includes a labyrinth ferrule including an annular ferrule body having a central bore extending therethrough. The labyrinth ferrule further includes an annular assembly cone formed at a first end of the labyrinth ferrule. The annular assembly cone includes an annular convergent lip and is configured to facilitate directing the instrument into the central bore. The labyrinth ferrule also includes a plurality of labyrinthine annular restrictions extending from a radially inner surface of the annular body toward the central bore. A combustor and a gas turbine engine including such a seal assembly are also provided.

Abstract: A method for manufacturing an electromagnetic shielding film of reduced thickness and a simplified manufacturing process includes forming a conductive ink layer by inkjet printing, on a component to be shielded, forming an insulative ink layer on the conductive ink layer by inkjet printing, and sintering the conductive ink layer and the insulative ink layer to form an electromagnetic shielding layer and an insulative layer, thereby obtaining the electromagnetic shielding film.

Abstract: A policy interpreter detects that an application container has been added in a container system, and opens a stored manifest for the application container. The policy interpreter retrieves running services information regarding the application container, and generates a security policy for the application container. The security policy defines a set of actions for which the application container can perform, and the set of actions are determined using the manifest and the running service information associated with the application container. The policy interpreter loads the security policy at a security container. The security container blocks an action performed by the application container in response to determining that the action performed by the application container does not match any action in the set of actions defined in the security policy. The policy interpreter transmits the security policy to a graphical user interface container for presentation to a user via a display device.

Abstract: The present disclosure provides a shift register, a driving method thereof, a gate driver circuit and a display device. The shift register includes a first control module, a scanning control module and a first output module.

Abstract: A threat level analyzer probes for one or more threats within an application container in a container system. Each threat is a vulnerability or a non-conformance with a benchmark setting. The threat level analyzer further probes for one or more threats within a host of the container service. The threat level analyzer generates a threat level assessment score based on results from the probing of the one or more threats of the application container and the one or more threats of the host, and generates a report for presentation in a user interface including the threat level assessment score and a list of threats discovered from the probe of the application container and the host. A report is transmitted by the threat level analyzer to a client device of a user for presentation in the user interface.

Abstract: The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.

Abstract: A novel process for making PBI films starting from gel PBI membranes polymerized and casted in the PPA process wherein acid-imbibed gel PBIs are neutralized in a series of water baths and undergo controlled drying in association with a substrate material, yielding a PBI film without the use of organic solvents.