Abstract: A genetically modified mesenchymal stem cell (MSC) and medical use thereof in the treatment of tumors, the MSC including one or more exogenous nucleic acid molecule(s), wherein the exogenous nucleic acid molecule(s) include a region encoding one or more immune response-stimulating or immune response-modulating cytokine(s) operably linked to a promoter or promoter/enhancer combination. The invention encompasses the use of the cells in modulating the tumor microenvironment in order to attract immune effector cells and facilitate their activation and/or adoption of a memory phenotype.

Abstract: A top for a convertible, which has a rear window frame with a rear window and, in the closed state, at least one roof section situated in front of the rear window frame in the direction of travel. When there are two roof sections which are adjacent to each other when the top is closed, a respective extension, which is extended to the rear or front, is formed on the lateral border regions of one of the roof sections. The extension being configured as a seal carrier.

Abstract: A convertible has a top which can be opened and can be put away and which has a rear window frame and, when the top is closed, at least one surface bow situated in front of said rear window frame in the direction of travel. A coupling linkage for carrying out a relative movement of the surface bow with respect to the rear window frame is arranged between the rear window frame and the surface bow. It is essential for the invention that at least two surface bows which are situated in front of the rear window frame in the direction of travel are provided, which surface bows, when the top is closed, form a continuous roof contour together with the rear window frame. Furthermore, the coupling linkage is designed in such a manner that, at the beginning of the opening of the top, the second surface bow can be moved downward relative to the adjacent first surface bow and relative to the rear window frame out of the roof contour.

Abstract: A vehicle roof has at least two roof segments which, in the closed position of the roof, support a flexible roof skin at least in some regions and can be shifted via at least two pairs of links in a positively controlled manner from a closed position G of the top into a fixed storage position A of the top and vice-versa. One pair of links is thereby drivable by motor in order to move all of the roof parts. In the storage position A of the top, the driven pair of links can be supported by a first vehicle-body-side stop on each side of the vehicle in order to fix all of the roof parts with defined distances being maintained at least between the at least two pairs of links.

Abstract: A motor vehicle roof configuration which can be put away has at least two shaping sections, which are movable relative to one another and can be put away together, for lateral convertible top cloth strips. The shaping sections lie in a row next to one another in a closed position of the roof configuration and have water channels which run approximately parallel to each convertible top cloth strip and in the longitudinal direction of the vehicle and also adjacent to the convertible top cloth strips. It is provided that, at least in a closed position of the roof configuration, an inner edge of each convertible top cloth strip together with at least one sealing configuration forms a leakproof covering for the adjacent water channel.

Abstract: A top drive for a flexible vehicle roof which can be transferred from a closed position into a storage position and vice versa. At least one roof link is movable via a linear drive, the roof link and a fixed end of the linear drive being fastened to a main bearing of the top, wherein an actuating end of the linear drive is fastened pivotably to a throw-over lever which is fastened to the main bearing of the top and at the free end of which there is arranged a drive connecting rod which is fastened at a first end in an articulated manner to the free end of the throw-over lever and at a second end in an articulated manner to a section of the roof link, which section is spaced apart from the pivot point on the main bearing of the top, as a result of which a driving movement of the linear drive can be transmitted to the roof link.

Abstract: A top for a convertible has a rear window frame, at least one roof section placed in front of it in the direction of travel when the top is closed, and a lateral top linkage. When the top is closed, a further roof section which is connected to the top linkage in an articulated manner and can be driven by the latter is provided between a front roof section and the rear window frame.

Abstract: A top for a convertible, which has a rear window frame with a rear window and, in the closed state, at least one roof section situated in front of the rear window frame in the direction of travel. When there are two roof sections which are adjacent to each other when the top is closed, a respective extension, which is extended to the rear or front, is formed on the lateral border regions of one of the roof sections. The extension being configured as a seal carrier.

Abstract: A top for a convertible has a linkage with which a plurality of roof sections can be displaced between a closed position and an open position. The rearmost roof section is configured as a rear window frame, and the linkage has a control link which is mounted pivotally on a bracket which can be fastened or is fastened to the vehicle. The linkage has a clamping hoop and a coupling linkage for controlling the kinematics of the rear window frame, said coupling linkage having a front coupling link and a rear coupling link which are mounted pivotally on the clamping hoop and on the rear window frame. In order to stabilize the top in its end positions, for the rear coupling link, there is formed on the clamping hoop a front stop against which the rear coupling link bears when the top is closed, and a rear stop against which the rear coupling link bears when the top is open.

Abstract: A top for a convertible has a top linkage forming a lateral roof frame at each side, and a flexible covering which is stretched open when the top is closed and covers at least parts of the top. When the top is closed, a seal is disposed between a stiffened region of the stretched-open covering, which region faces the associated lateral roof frame, and the associated lateral roof frame.

Abstract: A convertible has a top which can be opened and can be put away and which has a rear window frame and, when the top is closed, at least one surface bow situated in front of said rear window frame in the direction of travel. A coupling linkage for carrying out a relative movement of the surface bow with respect to the rear window frame is arranged between the rear window frame and the surface bow. It is essential for the invention that at least two surface bows which are situated in front of the rear window frame in the direction of travel are provided, which surface bows, when the top is closed, form a continuous roof contour together with the rear window frame. Furthermore, the coupling linkage is designed in such a manner that, at the beginning of the opening of the top, the second surface bow can be moved downward relative to the adjacent first surface bow and relative to the rear window frame out of the roof contour.

Abstract: A convertible has a top which can be opened and can be put away and which has a rear window frame and, when the top is closed, at least one surface bow situated in front of said rear window frame in the direction of travel. A coupling linkage for carrying out a relative movement of the surface bow with respect to the rear window frame is arranged between the rear window frame and the surface bow. It is essential for the invention that at least two surface bows which are situated in front of the rear window frame in the direction of travel are provided, which surface bows, when the top is closed, form a continuous roof contour together with the rear window frame. Furthermore, the coupling linkage is designed in such a manner that, at the beginning of the opening of the top, the second surface bow can be moved downward relative to the adjacent first surface bow and relative to the rear window frame out of the roof contour.

Abstract: A flexible vehicle roof has a flexible roof skin and a plurality of supporting elements that interact with the roof skin. The supporting elements are configured at least partially in some regions as sheet-like surface elements that support the roof skin. The supporting elements can be shifted together with the roof skin from a closed position into an open position opening up the vehicle interior, with it being possible for a plurality of the surface elements to be brought into overlap at least in some regions. In the open position, a front surface element forming the roof lug is disposed above a rear element surrounding a rear window, and a third surface element which, in the closed position, is disposed between the front and the rear elements can be displaced during the opening phase in a positively coupled manner into a packing position located below the rear element.

Abstract: A motor vehicle roof configuration which can be put away has at least two shaping sections, which are movable relative to one another and can be put away together, for lateral convertible top cloth strips. The shaping sections lie in a row next to one another in a closed position of the roof configuration and have water channels which run approximately parallel to each convertible top cloth strip and in the longitudinal direction of the vehicle and also adjacent to the convertible top cloth strips. It is provided that, at least in a closed position of the roof configuration, an inner edge of each convertible top cloth strip together with at least one sealing configuration forms a leakproof covering for the adjacent water channel.

Abstract: A motor vehicle has a body, a roof that can be displaced between an open position and closed position and having a roof skin with a rear window, and a rollover protection element that can be extended from an inoperative position into a protective position. In the protective position and with the roof in the closed position, the rollover protective element protrudes above the roof skin in the vicinity of the rear window. For improved rollover protection, it is proposed that the rear window is surrounded at least in some sections by a stiff window frame and is attached thereto, and that, in the closed position of the roof, the window frame is supported in relation to the body.

Abstract: A motor vehicle has a roof which can be adjusted between an opened and a closed position, and which has a roof skin. A rollover protection element can be moved out from an inoperative position into a protection position. For improved rollover protection, when the roof is in the closed position, the rollover protection element projects over the roof skin in the protection position.

Abstract: A motor vehicle wind deflector contains a stretching bow mounted to be pivotable around a first fixed pivot axis running transversely to the vehicle. A flexible flat structure which is rollable onto and unrollable from a rolling axis parallel to stretching bow axis is attached to the stretching bow to which a roof arch is also connected. The roof arch is mounted to be pivotable around a second fixed pivot axis extending transversely to the vehicle, which second axis is spaced in the longitudinal direction of the vehicle from the first pivot axis. The stretching bow is connected via a movable coupling mechanism to the roof arch.

Abstract: A convertible has a top which can be opened and can be put away and which has a rear window frame and, when the top is closed, at least one surface bow situated in front of said rear window frame in the direction of travel. A coupling linkage for carrying out a relative movement of the surface bow with respect to the rear window frame is arranged between the rear window frame and the surface bow. It is essential for the invention that at least two surface bows which are situated in front of the rear window frame in the direction of travel are provided, which surface bows, when the top is closed, form a continuous roof contour together with the rear window frame. Furthermore, the coupling linkage is designed in such a manner that, at the beginning of the opening of the top, the second surface bow can be moved downward relative to the adjacent first surface bow and relative to the rear window frame out of the roof contour.

Abstract: A top drive for a flexible vehicle roof which can be transferred from a closed position into a storage position and vice versa. At least one roof link is movable via a linear drive, the roof link and a fixed end of the linear drive being fastened to a main bearing of the top, wherein an actuating end of the linear drive is fastened pivotably to a throw-over lever which is fastened to the main bearing of the top and at the free end of which there is arranged a drive connecting rod which is fastened at a first end in an articulated manner to the free end of the throw-over lever and at a second end in an articulated manner to a section of the roof link, which section is spaced apart from the pivot point on the main bearing of the top, as a result of which a driving movement of the linear drive can be transmitted to the roof link.

Abstract: A top for a convertible has a linkage with which a plurality of roof sections can be displaced between a closed position and an open position. The rearmost roof section is configured as a rear window frame, and the linkage has a control link which is mounted pivotally on a bracket which can be fastened or is fastened to the vehicle. The linkage has a clamping hoop and a coupling linkage for controlling the kinematics of the rear window frame, said coupling linkage having a front coupling link and a rear coupling link which are mounted pivotally on the clamping hoop and on the rear window frame. In order to stabilize the top in its end positions, for the rear coupling link, there is formed on the clamping hoop a front stop against which the rear coupling link bears when the top is closed, and a rear stop against which the rear coupling link bears when the top is open.