Patents by Inventor Fengwei Tian

Fengwei Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11628192
    Abstract: The disclosure discloses Bacteroides fragilis for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides fragilis CCFM1020 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of hosts infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides fragilis CCFM1020 for relieving endotoxin infection has broad application prospects.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: April 18, 2023
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Qixiao Zhai, Wei Chen, Huizi Tan, Wenwei Lu, Fengwei Tian, Jianxin Zhao, Hao Zhang
  • Patent number: 11419905
    Abstract: The disclosure discloses Bacteroides ovatus for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides ovatus CCFM1021 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of mice infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides ovatus CCFM1021 for relieving endotoxin infection has broad application prospects.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: August 23, 2022
    Assignee: Jiangnan University
    Inventors: Wei Chen, Qixiao Zhai, Huizi Tan, Wenwei Lu, Fengwei Tian, Jianxin Zhao, Hao Zhang
  • Publication number: 20220228106
    Abstract: The disclosure discloses a strain of Lactobacillus rhamnosus and application thereof in inhibiting Helicobacter pylori, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus rhamnosus CCFM1119. The Lactobacillus rhamnosus CCFM1119 can prevent and/or treat Helicobacter pylori infection, specifically embodied in that: (1) the Lactobacillus rhamnosus CCFM1119 can significantly relieve the gastrointestinal symptoms of patients with Helicobacter pylori infection; (2) the Lactobacillus rhamnosus CCFM1119 can significantly reduce the amount of colonization of Helicobacter pylori in patients with Helicobacter pylori infection; and (3) the Lactobacillus rhamnosus CCFM1119 can significantly increase the clearance rate of Helicobacter pylori in patients with Helicobacter pylori infection.
    Type: Application
    Filed: April 1, 2022
    Publication date: July 21, 2022
    Inventors: Qixiao ZHAI, Wei CHEN, Jianxin ZHAO, Meiyi ZHANG, Shumao CUI, Wenwei LU, Fengwei TIAN, Leilei YU, Gang WANG, Hao ZHANG
  • Publication number: 20220218769
    Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 14, 2022
    Inventors: Qixiao ZHAI, Wei CHEN, Meiyi ZHANG, Leilei YU, Fengwei TIAN, Shunhe WANG, Jianxin ZHAO, Hao ZHANG
  • Publication number: 20210060091
    Abstract: The disclosure discloses Bacteroides ovatus for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides ovatus CCFM1021 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of mice infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides ovatus CCFM1021 for relieving endotoxin infection has broad application prospects.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 4, 2021
    Inventors: Wei CHEN, Qixiao ZHAI, Huizi TAN, Wenwei LU, Fengwei TIAN, Jianxin ZHAO, Hao ZHANG
  • Publication number: 20210038655
    Abstract: The disclosure discloses Bacteroides fragilis for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides fragilis CCFM1020 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of hosts infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides fragilis CCFM1020 for relieving endotoxin infection has broad application prospects.
    Type: Application
    Filed: October 28, 2020
    Publication date: February 11, 2021
    Inventors: Qixiao ZHAI, Wei CHEN, Huizi TAN, Wenwei LU, Fengwei TIAN, Jianxin ZHAO, Hao ZHANG
  • Patent number: 9649347
    Abstract: An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 16, 2017
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Wei Chen, Fengwei Tian, Wenli Huang, Jianxin Zhao, Hao Zhang, Gang Wang, Qiuxiang Zhang, Xiaoming Liu, Daming Fan, Feifei Chi
  • Patent number: 9451781
    Abstract: The invention provides a novel strain of cadmium-removing Lactobacillus plantarum bacterium, CCFM8610, which has a good tolerance to acidic environments. Lactobacillus plantarum CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion. Lactobacillus plantarum CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: September 27, 2016
    Assignee: Jiangnan University
    Inventors: Wei Chen, Fengwei Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Qiuxiang Zhang, Daming Fan, Jianxin Zhao, Hao Zhang
  • Publication number: 20160113975
    Abstract: An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 28, 2016
    Applicant: Jiangnan University
    Inventors: Wei Chen, Fengwei Tian, Wenli Huang, Jianxi n Zhao, Hao Zhang, Gang Wang, Qiuxiang Zhang, Xiaoming Liu, Daming Fan, Feifei Chi
  • Patent number: 9320766
    Abstract: The Lactobacillus plantarum CCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: April 26, 2016
    Assignee: Jiangnan University
    Inventors: Fengwei Tian, Wei Chen, Qixiao Zhai, Hao Zhang, Jianxin Zhao, Gang Wang, Yuanda Song, Qiuxiang Zhang, Xiaoming Liu, Min Guo, Daming Fan
  • Patent number: 9315836
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially ?3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: April 19, 2016
    Assignee: University of Jiangnan
    Inventors: Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, Yuanda Song, Fengwei Tian, Jianxin Zhao, Yongquan Chen
  • Patent number: 9115339
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially delta-9 desaturases (FADS9-I). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: August 25, 2015
    Assignee: UNIVERSITY OF JIANGNAN
    Inventors: Wei Chen, Haiqun Chen, Zhennan Gu, Hao Zhang, Yuanda Song, Jianxin Zhao, Fengwei Tian, Yongquan Chen
  • Publication number: 20150056328
    Abstract: It relates to the manufacturing and preparation of frozen dough, and its application in microwaveable fried food. The preparation of fried fritters comprises the following steps: disposal of raw materials, dough kneading, dough proofing for the first time, dough folding, dough proofing for the second time, making blanks, frying and quick-freezing. Alum as the acidic component in leavening agents is replaced by a complex formulation of gluconic acid-?-lactone, glycerol monolaurate and calcium dihydrogen phosphate, thus reducing the toxicity of the dough. The fried fritters preparing by the dough of the present invention possess a good expansion rate, crispness and taste, and should satisfy consumer demands for quality food products that can be reheated by microwaving.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 26, 2015
    Applicant: Jiangnan University
    Inventors: Wei Chen, Daming Fan, Hao Zhang, Jianxin Zhao, Fengwei Tian
  • Patent number: 8962276
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially omega-3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Grant
    Filed: October 6, 2012
    Date of Patent: February 24, 2015
    Assignee: University of Jiangnan
    Inventors: Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, Yuanda Song, Fengwei Tian, Jianxin Zhao, Yongquan Chen
  • Publication number: 20140369981
    Abstract: The Lactobacillus plantarum CCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.
    Type: Application
    Filed: July 18, 2012
    Publication date: December 18, 2014
    Applicant: Jiangnan University
    Inventors: Fengwei Tian, Wei Chen, Qixiao Zhai, Hao Zhang, Jianxin Zhao, Gang Wang, Yuanda Song, Qiuxiang Zhang, Xiaoming Liu, Min Guo, Daming Fan
  • Publication number: 20140363501
    Abstract: An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.
    Type: Application
    Filed: July 19, 2012
    Publication date: December 11, 2014
    Applicant: Jiangnan University
    Inventors: Wei Chen, Fengwei Tian, Wenli Huang, Jianxi n Zhao, Hao Zhang, Gang Wang, Qiuxiang Zhang, Xiaoming Liu, Daming Fan, Feifei Chi
  • Publication number: 20140363860
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially ?3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Application
    Filed: July 4, 2014
    Publication date: December 11, 2014
    Applicant: University of Jiangnan
    Inventors: Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, Yuanda Song, Fengwei Tian, Jianxin Zhao, Yongquan Chen
  • Publication number: 20140341873
    Abstract: The invention provides a novel strain of cadmium-removing Lactobacillus plantarum bacterium, CCFM8610, which has a good tolerance to acidic environments. Lactobacillus plantarum CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion. Lactobacillus plantarum CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 20, 2014
    Inventors: Wei Chen, Fengwei Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Qiuxiang Zhang, Daming Fan, Jianxin Zhao, Hao Zhang
  • Publication number: 20140099683
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially omega-3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Application
    Filed: October 6, 2012
    Publication date: April 10, 2014
    Applicant: UNIVERSITY OF JIANGNAN
    Inventors: Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, Yuanda Song, Fengwei Tian, Jianxin Zhao, Yongquan Chen
  • Publication number: 20140065691
    Abstract: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially delta-9 desaturases (FADS9-I). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.
    Type: Application
    Filed: August 22, 2013
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF JIANGNAN
    Inventors: WEI CHEN, HAIQUN CHEN, ZHENNAN GU, HAO ZHANG, YUANDA SONG, JIANXIN ZHAO, FENGWEI TIAN, YONGQUAN CHEN