Patents by Inventor Flemming Besenbacher

Flemming Besenbacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140350680
    Abstract: The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system.
    Type: Application
    Filed: December 22, 2012
    Publication date: November 27, 2014
    Inventors: Dang Quang Svend Le, Muwan Chen, Menglin Chen, Anette Overgaard Baatrup, Cody Eric Bünger, Helle Lysdahl, Jørgen Kjems, Morten Østergaard Andersen, Flemming Besenbacher
  • Publication number: 20140329323
    Abstract: A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarcially organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.
    Type: Application
    Filed: July 16, 2014
    Publication date: November 6, 2014
    Inventors: Jens Vinge Nygaard, Lea Bjerre, Cody Eric Bünger, Flemming Besenbacher
  • Patent number: 8815276
    Abstract: A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarchically organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: August 26, 2014
    Assignees: Aarhus Universitet, Region Midtjylland
    Inventors: Jens Vinge Nygaard, Lea Bjerre, Cody Eric Bünger, Flemming Besenbacher
  • Patent number: 8741631
    Abstract: A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 3, 2014
    Assignees: Aarhus Universitet, Region Midtjylland
    Inventors: Dang Quang Svend Le, Jens Vinge Nygaard, Morten Foss, Flemming Besenbacher, Cody Bünger
  • Patent number: 8470600
    Abstract: A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: June 25, 2013
    Assignee: Aarhus Universitet
    Inventors: Mogens Ryttergård Duch, Lotte Markert, Jette Lovmand, Annette Christine Füchtbauer, Ernst Martin Füchtbauer, Morten Foss, Flemming Besenbacher, Finn Skou Pedersen
  • Publication number: 20120171718
    Abstract: A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.
    Type: Application
    Filed: June 3, 2010
    Publication date: July 5, 2012
    Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITET
    Inventors: Dang Quang Svend Le, Jens Vinge Nygaard, Morten Foss, Flemming Besenbacher, Cody Bünger
  • Publication number: 20120128739
    Abstract: A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarchically organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.
    Type: Application
    Filed: June 25, 2010
    Publication date: May 24, 2012
    Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITET
    Inventors: Jens Vinge Nygaard, Lea Bjerre, Cody Eric Bunger, Flemming Besenbacher
  • Publication number: 20120040004
    Abstract: The present invention relates to treatment or prevention of radiation induced fibrosis using TNF-alpha antagonism. Preferably, TNF-alpha is antagonized by direct binding or by inhibition of synthesis. In a preferred embodiment, the invention comprises intraperitoneal administration of a chitosan-siRNA nanoparticle, wherein the siRNA is targeted to the mRNA encoding TNF-alpha.
    Type: Application
    Filed: January 28, 2010
    Publication date: February 16, 2012
    Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITET
    Inventors: Kenneth Alan Howard, Jørgen Kjems, Isabel Nawroth, Jan Alsner, Jens Overgaard, Flemming Besenbacher
  • Publication number: 20110160869
    Abstract: A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.
    Type: Application
    Filed: May 27, 2009
    Publication date: June 30, 2011
    Applicant: Aarhus Universitet
    Inventors: Mogens Ryttergård Duch, Lotte Markert, Jette Lovmand, Annette Christine Füchtbauer, Ernst Martin Füchtbauer, Morten Foss, Flemming Besenbacher, Finn Skou Pedersen
  • Publication number: 20110124255
    Abstract: The present invention relates to a process for coating a polymer nonwoven comprising the steps of: plasma and/or corona assisted treatment of the surface of the nonwoven to obtain a charged and/or polar surface; and formation of a first coating layer comprising at least one first charged and/or polar species, the first species being a hydrophilic polymer, wherein the overall charge or partial charge facing the nonwoven surface of the first species carries the opposite sign from the average charge introduced to the nonwoven fiber surface in step a).
    Type: Application
    Filed: November 23, 2010
    Publication date: May 26, 2011
    Applicant: FIBERTEX A/S
    Inventors: Thomas Broch-Nielsen, Jens Bøndergaard, Flemming Besenbacher, Peter Kingshott
  • Publication number: 20110033547
    Abstract: The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved storage characteristics. The particles may be used in screening methods, e.g. where they have been dried onto a solid support, such as the surface of a culture well. The nanoparticles may also be dried onto implants for tissue engineering scaffolds, where they enable transfection of cells growing on the scaffold. Moreover, the particles have therapeutic relevance.
    Type: Application
    Filed: July 4, 2008
    Publication date: February 10, 2011
    Applicant: Aarhus Universitet
    Inventors: Jørgen Kjems, Kenneth Alan Howard, Flemming Besenbacher, Morten Østergaard Andersen
  • Publication number: 20100298719
    Abstract: A method for calculating pressures in a fluid streaming through a tube section from an upstream end to a downstream end of the tube section, the method comprising scanning the tube section with a scanner and providing a plurality of 2D scanning images along the tube section with an inlet and at least two arms, by a computer program on the basis of the 2D images automatically N calculating a 3D image of the tube section by using interpolating between the 2D images, by a computer program performing a 2D sectional image cut through the 3D image, the image cut following the fluid stream, calculating in the sectional image cut a fluid pressure distribution along multiple locations inside the tube on the basis of given boundary conditions, the boundary conditions including fluid velocity or fluid pressure at the upstream end.
    Type: Application
    Filed: October 31, 2008
    Publication date: November 25, 2010
    Inventors: Samuel Alberg Kock, Jens Vinge Nygaard, Flemming Besenbacher, Won Yong Kim
  • Publication number: 20100272813
    Abstract: The present invention provides nanoparticles for treatment of inflammatory diseases. The nanoparticles preferably comprise chitosan and a siRNA targeting a mRNA encoding a pro-inflammatory cytokine, such as e.g. tnf-alfa. A preferred route of administration of the nanoparticles is by injection intraperitoneally.
    Type: Application
    Filed: July 23, 2008
    Publication date: October 28, 2010
    Applicant: AARHUS UNIVERSITET
    Inventors: Jørgen Kjems, Kenneth Alan Howard, Flemming Besenbacher, Bent Deleuran
  • Publication number: 20100267139
    Abstract: The present invention relates to nanoparticles comprising osteopontin and a polymer carrier, preferably a cationic carrier. Preferably, the cationic carrier is chitosan. Osteopontin and/or the cationic carrier may have bioactivity and/or the nanoparticle may comprise an additional component with bioactivity. Such additional bioactive component may e.g. be a siRNA. The nanoparticles of the invention may be used for treatment of bone diseases or inflammatory diseases.
    Type: Application
    Filed: July 16, 2008
    Publication date: October 21, 2010
    Applicant: AARHUS UNIVERSITET
    Inventors: Jørgen Kjems, Kenneth Alan Howard, Flemming Besenbacher, Morten Andreasen
  • Publication number: 20100015232
    Abstract: The present invention provides chitosan/RNA nanoparticles that are useful as research tools or medicaments. Preferably, the RNA part of the nanoparticle is a siRNA capable of modulating the expression of a target mRNA. The invention also provides methods for the preparation of chitosan/RNA nanoparticles.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 21, 2010
    Inventors: Flemming Besenbacher, Kenneth Alan Howard, Jorgen Kjems, Xiudong Liu
  • Publication number: 20090246567
    Abstract: Process for suppressing the formation of solid carbon in a fuel cell comprising contacting a hydrocarbon feedstock with a promoted nickel-comprising anode, the promoter including gold or silver in an amount of 0.001 to 30% by weight calculated on the amount of nickel in the anode.
    Type: Application
    Filed: June 10, 2004
    Publication date: October 1, 2009
    Inventors: Jens Henrik Hyldtoft, Flemming Besenbacher, Jens Kehlet Norskov, Bjerne Steffen Clausen, Ronnie Vang, Christian Gert Lundtorp Olsen, Ebbe Kruse Vestergaard
  • Publication number: 20090227164
    Abstract: A superhydrophobic coating of a nonwoven material is coated with a spongy mesh structure in the micro and nano ranges.
    Type: Application
    Filed: October 27, 2006
    Publication date: September 10, 2009
    Inventors: Thomas Broch-Nielsen, Jens Bondergaard, Flemming Besenbacher, Peter Kingshott, Søren Mølgaard
  • Publication number: 20080227656
    Abstract: A biosurface structure array (BSSA) comprising a plurality of tester areas whereby each area has a surface topology whose features are defined on a micro- or nanometer scale. The BBSA of the invention may further comprise adsorbed compounds to one or more of the tester fields, e.g. active biological compounds or polymers.
    Type: Application
    Filed: April 25, 2006
    Publication date: September 18, 2008
    Inventors: Flemming Besenbacher, Mogens Ryttergard Duch, Morten Foss, Fin Skou Pedersen
  • Publication number: 20080208351
    Abstract: A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote a predetermined cell function in vivo or ex vivo in cell or tissue culture.
    Type: Application
    Filed: April 25, 2006
    Publication date: August 28, 2008
    Applicant: Aarhus Universitet
    Inventors: Flemming Besenbacher, Mogens Ryttergard Duch, Morten Foss, Finn Skou Pedersen, Jeannette Hoffmann Frisch Justesen, Lars Klembt Andersen, Trine Elkjaer Larsen Crovato, Lotte Markert