Patents by Inventor Florencia Marine McAllister

Florencia Marine McAllister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHARACTERIZATION OF IL-17F AND IL-17R INTERACTIONS
    Publication number: 20100322897
    Abstract: The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial cells. Thus, the present invention provides isolated and purified IL-17F or IL-17R polynucleotides and polypeptides. The present invention also is directed to novel methods for screening test compounds capable of inhibiting, i.e., decreasing, limiting, blocking, or otherwise reducing, IL-17F bioactivity, and methods for diagnosing, prognosing, and monitoring the progress of, disorders related to IL-17F bioactivity, e.g., disorders related to the effects of IL-17F binding to IL-17R on airway inflammation, e.g., in patients with cystic fibrosis, including pulmonary exacerbations due to bacterial infections in same. The present invention is further directed to novel therapeutics and therapeutic targets and to methods for the intervention (treatment) and prevention of said disorders related to IL-17F bioactivity.
    Type: Application
    Filed: April 26, 2010
    Publication date: December 23, 2010
    Inventors: Jay K. Kolls, Florencia Marine McAllister, Beatriz M. Carreno, Samuel J. Goldman
  • Use of IL-17F in diagnosis and therapy of airway inflammation
    Patent number: 7704503
    Abstract: The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial cells. Thus, the present invention provides isolated and purified IL-17F or IL-17R polynucleotides and polypeptides. The present invention also is directed to novel methods for screening test compounds capable of inhibiting, i.e., decreasing, limiting, blocking, or otherwise reducing, IL-17F bioactivity, and methods for diagnosing, prognosing, and monitoring the progress of, disorders related to IL-17F bioactivity, e.g., disorders related to the effects of IL-17F binding to IL-17R on airway inflammation, e.g., in patients with cystic fibrosis, including pulmonary exacerbations due to bacterial infections in same. The present invention is further directed to novel therapeutics and therapeutic targets and to methods for the intervention (treatment) and prevention of said disorders related to IL-17F bioactivity.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: April 27, 2010
    Assignees: Wyeth LLC, University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Jay K. Kolls, Florencia Marine McAllister, Beatriz M. Carreno, Samuel J. Goldman