Abstract: Aspects of this invention inter alia relate to novel systems for targeting, editing or manipulating DNA in a cell, comprising one or more heterologous vector(s) encoding a SluCas9 nuclease from Staphylococcus lugdunensis or variants thereof, and one or more guide RNAs (gRNAs), or a SluCas9 nuclease or variant thereof and one or more gRNAs.

Abstract: PMMA-based rigid foams can be used as the core material of sandwich components in rotor blades of wind power plants and in boatbuilding.

Abstract: The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control

Abstract: A system and computer implemented method for automatically checking non-compliance of device firmware (30) is disclosed. The method comprises receiving (200) an image (50) of the device firmware (30) to a pipeline (40) and accessing (225) at least one requirement (125) from a guidelines database (120). The guidelines database (120) comprises a plurality of guideline documents (310) and common requirements (340), wherein the common requirements (340) are common to a plurality of the guideline documents (310). At least detection rule (140) on the downloaded device firmware (30) is run (230) to detect a violated one of the at least one requirement (125) in the device firmware (30) and the violated requirement is flagged (225) in a compliance database (135).

Abstract: An avalanche photodiode array for detecting electromagnetic radiation comprises: a semiconductor substrate (100) having a first main surface (101) and a second main surface (102), which are opposite one another, a plurality of n-doped anode regions (1) formed at the first main surface (101) and separated from one another by pixel isolation regions (7), a p-doped cathode region (3) arranged at the second main surface (102) opposite the anode regions, a drift region (4) between the plurality of anode regions (1) and the cathode region (3), and a p-doped multiplication layer (2) arranged below the plurality of anode regions (1) and below the pixel isolation regions (7), and is characterized by an n-doped field reduction layer (9) arranged below the plurality of anode regions (1) and the pixel isolation regions (7) and above the multiplication layer (2).

Abstract: A method for improving prediction results of advanced driver assistance systems of a vehicle includes obtaining map data including information about a road geometry in a proximity of the vehicle. A sensor means is assigned, sensing a surrounding of the vehicle. A virtual sensing means output is generated, corresponding to an output of the sensing means if the sensing means. The generation is based on a mathematical model of the sensing means. The surrounding of the vehicle is sensed, and a sensing means output is generated. The sensing means output is compared to the virtual sensing means output. Parameters of the mathematical model are modified, and the virtual sensing means output are generated and compared to the sensing means output. Map data is combined with information derived from the sensing means output to generate combined information, which is output for further processing.

Abstract: Disclosed is a mussel adhesive protein including at least one photocaged 3,4-dihydroxyphenylalanine derivative residue including a protecting group on at least one hydroxyl residue of its catechol moiety. The photocaged 3,4-dihydroxyphenylalanine derivative residue replaces a naturally occurring amino acid and the protecting group can be cleaved from the 3,4-dihydroxyphenylalanine derivative residue by irradiation with UV light.

Abstract: Disclosed is a method of reducing a haze value in molding compositions including use of colorants selected from anthraquinone colorants, benzimidazolone colorants and perinone colorants.

Abstract: The present invention relates to a polymer film (P), comprising at least one copolyamide, wherein the copolyamide has been prepared by polymerizing at least one lactam (A) and a monomer mixture (M). The present invention further relates to a process for producing the polymer film (P) and to the use of the polymer film (P) as packaging film.

Abstract: The present invention relates to a polyamide composition (PC) which comprises at least one polyamide (P) and at least one additive (A). The present invention further relates to the use of the polyamide composition (PC) in a selective laser sintering process, in an injection molding process, for producing molded articles and in an extrusion process.

Abstract: The present invention relates to semi-aromatic copolyamides having a high glass transition temperature and a high degree of crystallinity, to a polyamide molding compound containing said semi-aromatic copolyimide and to the use of the semi-aromatic copolyamides and of the polyamide molding compounds.

Abstract: Disclosed is a mussel adhesive protein including at least one photocaged 3,4-dihydroxyphenylalanine derivative residue including a protecting group on at least one hydroxyl residue of its catechol moiety. The photocaged 3,4-dihydroxyphenylalanine derivative residue replaces a naturally occurring amino acid and the protecting group can be cleaved from the 3,4-dihydroxyphenylalanine derivative residue by irradiation with UV light.

Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.

Abstract: Aspects of this invention inter alia relate to novel systems for targeting, editing or manipulating DNA in a cell, comprising one or more heterologous vector(s) encoding a SluCas9 nuclease from Staphylococcus lugdunensis or variants thereof, and one or more guide RNAs (gRNAs), or a SluCas9 nuclease or variant thereof and one or more gRNAs.

Abstract: Disclosed is a method of reducing a haze value in molding compositions including use of colorants selected from anthraquinone colorants, benzimidazolone colorants and perinone colorants.

Abstract: The invention relates to a process for continuously preparing polyamide oligomers. This comprises continuous conveying of an aqueous solution of polyamide-forming monomers from a reservoir vessel into an oligomerization reactor, heating of the aqueous solution beyond a dissolution or storage temperature, the residence time of the monomer solution in the oligomerization reactor being limited and the pressure or the partial vapor pressure of the water being adjusted such that a conversion of monomers to polyamide oligomers does not exceed a maximum value and/or the polyamide oligomers formed do not phase-separate or spontaneously crystallize in solid form, and continuous discharge of the polyamide oligomers from the oligomerization reactor. A polyamide oligomer preparable by this process can be provided continuously in a mixture with water in a process for preparing a semicrystalline or amorphous, thermoplastically processible polyamide and then postcondensed to give a polyamide.

Abstract: The invention relates to the use of thermoplastic molding compositions comprising A) 30 to 99.99 wt % of a thermoplastic polyamide, B) 0.01 to 10 wt % of a compound of formula I where A) represents a or —O—R5 radical or B) represents a or —O—R6 radical or and Z represents linear or branched C1 to C14 alkylene radicals, unsubstituted or substituted cycloalkylene radicals having 3 to 17 carbon atoms, substituted or unsubstituted aromatic radicals having 6 to 20 carbon atoms, R1 to R10 independently of one another represent linear C1-C14 alkyl radicals, branched C3 to C12 alkyl radicals, unsubstituted or substituted C3-C14 cycloalkyl radicals, unsubstituted or substituted aromatic radicals having 6 to 20 carbon atoms or acetyl radicals, R1 and R2 and also R3 and R4 independently of one another, together with the nitrogen as a linking member, form a heteroalkylene radical which may bear one or two keto groups as substituent(s).

Abstract: The present invention relates to a polymer film (P), comprising at least one copolyamide, wherein the copolyamide has been prepared by polymerizing at least one lactam (A) and a monomer mixture (M). The present invention further relates to a process for producing the polymer film (P) and to the use of the polymer film (P) as packaging film.

Abstract: The present invention relates to a process for producing a polymer film (P) comprising at least one copolyamide by extrusion of the copolyamide through a ring die and subsequent stretching of the tube thus obtained by blowing in air. The present invention further relates to the polymer film (P) obtainable by the process of the invention and to a process for packing foods.

Abstract: The present invention relates to a method for producing semi-aromatic copolyamides with a high diamine excess in the reaction batch.