Patents by Inventor Frances M. Smith

Frances M. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8062881
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: November 22, 2011
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Publication number: 20100280174
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and fault the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Application
    Filed: July 8, 2010
    Publication date: November 4, 2010
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, JR., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 7776572
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: August 17, 2010
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Publication number: 20080145280
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 19, 2008
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 7312057
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: December 25, 2007
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 6819846
    Abstract: An optical waveguide fiber amplifier comprising a core region comprises at least in part between 1300 wt.ppm and 3600 wt.ppm Er2O3, between 6.0 wt. % to 10.0 wt. % Al2O3 and between 9.0 wt. % and 20.0 wt. % GeO2. The amplifier also comprising an inner clad surrounding the core region and an outer clad surrounding the inner clad. The relative refractive index percentages and radii of the core region, inner clad and outer clad are chosen from the following ranges: the relative refractive index percent of the core segment within the range of from about 0.5% to about 2.0%; the relative refractive index percent of the inner clad within the range of from about 0.0% to about 0.4%; the outer radius of the core region within the range of from about 0.7 &mgr;m to about 1.5 &mgr;m; and, the outer radius of the inner clad within the range of from about 4.3 &mgr;m to about 18.8 &mgr;m.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: November 16, 2004
    Assignee: Corning Incorporated
    Inventors: Rachel S. Mozdy, Atul D. Pradhan, Frances M. Smith, William A. Wood
  • Publication number: 20030199065
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Application
    Filed: March 3, 2003
    Publication date: October 23, 2003
    Applicant: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 6565789
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: May 20, 2003
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Publication number: 20030073067
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
    Type: Application
    Filed: February 18, 2000
    Publication date: April 17, 2003
    Inventors: Dana Craig Bookfinder, Edward John Fewkes, James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Publication number: 20030035638
    Abstract: An optical waveguide fiber amplifier comprising a core region comprises at least in part between 1300 wt.ppm and 3600 wt.ppm Er2O3, between 6.0 wt. % to 10.0 wt. % Al2O3 and between 9.0 wt. % and 20.0 wt. % GeO2. The amplifier also comprising an inner clad surrounding the core region and an outer clad surrounding the inner clad. The relative refractive index percentages and radii of the core region, inner clad and outer clad are chosen from the following ranges: the relative refractive index percent of the core segment within the range of from about 0.5% to about 2.0%; the relative refractive index percent of the inner clad within the range of from about 0.0% to about 0.4%; the outer radius of the core region within the range of from about 0.7 &mgr;m to about 1.5 &mgr;m; and, the outer radius of the inner clad within the range of from about 4.3 &mgr;m to about 18.8 &mgr;m.
    Type: Application
    Filed: July 26, 2002
    Publication date: February 20, 2003
    Inventors: Rachel S. Mozdy, Atul D. Pradhan, Frances M. Smith, William A. Wood
  • Patent number: 6319664
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: November 20, 2001
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 6093559
    Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm.sup.2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: July 25, 2000
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Edward John Fewkes, Jr., James Arthur Griffin, Frances M. Smith, David L. Tennent
  • Patent number: 6069099
    Abstract: A method of controlling the rheology of a sealing glass paste which comprises incorporating a fine inorganic powder in the paste as a mill addition to impart a steep rheology curve to the paste so that the paste resists flow while at rest, but flows readily when shear stress is applied, the amount of inorganic powder incorporated being not over about 10% by weight.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: May 30, 2000
    Assignee: Corning Incorporated
    Inventors: Edward J. Fewkes, Margaret E. Greene, Robert Morena, Frances M. Smith
  • Patent number: 5925308
    Abstract: A method of producing a formable mixture involves combining a powder material, and a plurality of gel-forming polymers, wherein at least one gel-forming polymer is a proton donor, and at least one gel forming polymer is a proton acceptor. A method of making a monolithic structure involves producing a formable mixture of powder material which can be ceramic, metal, glass, glass ceramic, molecular sieve and combinations thereof, a plurality of gel-forming polymers as described above, extruding the mixture to form a green monolithic structure, and drying and firing the green structure.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: July 20, 1999
    Assignee: Corning Incorporated
    Inventors: Edward J. Fewkes, Frances M. Smith, Lung-Ming Wu
  • Patent number: 5853446
    Abstract: A method and apparatus for making formed glass structures. A glass frit containing material is deposited within a recessed pattern, hardened in the recessed pattern, and transferred to a substrate. The method and apparatus of the invention are particularly useful for forming barrier rib structures for use in plasma display panels.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: December 29, 1998
    Assignee: Corning Incorporated
    Inventors: Alain R.E. Carre, Bernard Eid, Mark S. Friske, Ronald E. Johnson, Candace J. Quinn, Frances M. Smith, Jean-Pierre Themont
  • Patent number: 5563215
    Abstract: A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: October 8, 1996
    Assignee: Corning Incorporated
    Inventors: Marie D. Bryhan, Leroy S. Hersh, Frances M. Smith
  • Patent number: 5281660
    Abstract: A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: January 25, 1994
    Assignee: Corning Incorporated
    Inventors: Marie D. Bryhan, Leroy S. Hersh, Frances M. Smith