Abstract: The present invention provides systems and methods for performing automated auscultation and diagnosis of conditions of the cardiovascular system. The invention acquires an acoustic signal emanating from the cardiovascular system via an sensor. In addition, in certain embodiments of the invention an electrical signal, e.g., an electrocardiogram (EKG) is simultaneously acquired. The signals are digitized, and, optionally, filtered to remove noise. The invention then processes and analyses the signal(s) so as to provide a clinically relevant conclusion or recommendation such as a diagnosis or suggested additional tests or therapy.