Patents by Inventor Francesco CHEMELLO

Francesco CHEMELLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165271
    Abstract: Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by the lack of dystrophin, which maintains muscle membrane integrity. Provided herein are methods of using adenine base editor (ABE) to modify splice sites of the dystrophin gene, causing skipping or refraining of common DMD exon deletion mutations, restoring dystrophin expression. Also provided herein are methods of using prime editing to reframe the dystrophin open reading frame and restore dystrophin expression.
    Type: Application
    Filed: March 25, 2022
    Publication date: May 23, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Eric N. OLSON, Francesco CHEMELLO, Rhonda BASSEL-DUBY