Patents by Inventor Francine Farouz

Francine Farouz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11786524
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: October 17, 2023
    Assignee: SENTINEL ONCOLOGY LIMITED
    Inventors: Robert George Boyle, David Winter Walker, Richard Justin Boyce, Scott Peterson, Francine Farouz, Cong Hung Vo
  • Publication number: 20210275525
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Application
    Filed: March 3, 2021
    Publication date: September 9, 2021
    Applicant: SENTINEL ONCOLOGY LIMITED
    Inventors: Robert George BOYLE, David Winter WALKER, Richard Justin BOYCE, Scott PETERSON, Francine FAROUZ, Cong Hung VO
  • Patent number: 10973817
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: April 13, 2021
    Assignee: SENTINEL ONCOLOGY LIMITED
    Inventors: Robert George Boyle, David Winter Walker, Richard Justin Boyce, Scott Peterson, Francine Farouz, Cong Hung Vo
  • Publication number: 20180271860
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 27, 2018
    Applicant: Cascadian Therapeutics, Inc.
    Inventors: Robert George BOYLE, David Winter WALKER, Richard Justin BOYCE, Scott PETERSON, Francine FAROUZ, Cong Hung VO
  • Patent number: 10010547
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: July 3, 2018
    Assignee: Cascadian Therapeutics, Inc.
    Inventors: Robert George Boyle, David Winter Walker, Richard Justin Boyce, Scott Peterson, Francine Farouz, Cong Hung Vo
  • Publication number: 20160361310
    Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
    Type: Application
    Filed: February 9, 2015
    Publication date: December 15, 2016
    Inventors: Robert George BOYLE, David Winter WALKER, Richard Justin BOYCE, Scott PETERSON, Francine FAROUZ, Cong Hung VO
  • Patent number: 9370510
    Abstract: The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention also promote sensory hair cell regeneration. Particular compositions comprise ellipticine derivatives, and optionally one or more small molecules that increase Atoh1 expression or activity, and optionally one or more growth factors.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 21, 2016
    Assignee: Fate Therapeutics, Inc.
    Inventors: Robert Scott Thies, Francine Farouz, Zhiyong Wang, Chin-Chun Jean Lu
  • Publication number: 20150025096
    Abstract: The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention also promote sensory hair cell regeneration. Particular compositions comprise ellipticine derivatives, and optionally one or more small molecules that increase Atoh1 expression or activity, and optionally one or more growth factors.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 22, 2015
    Inventors: Robert Scott Thies, Francine Farouz, Zhiyong Wang, Chin-Chun Jean Lu
  • Publication number: 20110021541
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Application
    Filed: November 12, 2008
    Publication date: January 27, 2011
    Inventors: Stephen L. White, Fuqiang Ruan, Edward A. Kesicki, Eugene Thorsett, Francine Farouz
  • Publication number: 20100216820
    Abstract: The current invention provides compounds of formula (1): wherein: one of Q1, Q2 and Q3 is S, and the other of two of Q1, Q2 and Q3 are —CR1—, which are inhibitors of PI3K-delta. These compounds are useful for treatment of conditions mediated by PI3K-delta, such as hematopoietic cancers, immune disorders, and bone resorption disorders. The invention further provides pharmaceutical compositions comprising a compound of formula (1) and methods of using these compounds and compositions to treat conditions mediated by PI3K-delta.
    Type: Application
    Filed: November 13, 2007
    Publication date: August 26, 2010
    Inventors: Stephen L. White, Edward A. Kesicki, Eugene Thorsett, Fuqiang Ruan, Francine Farouz
  • Publication number: 20070259863
    Abstract: The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
    Type: Application
    Filed: April 28, 2005
    Publication date: November 8, 2007
    Applicants: ICOS Corporation, Biogen Idec MA Inc.
    Inventors: Donovan Chin, Thomas Durand-Reville, Francine Farouz, Kerry Fowler, Kevin Guckian, Irina Jaconbson, Ramesh Kasar, Russell Petter, Daniel Scott, C. Gregory Sowell, Eugene Thorsett, Edward Yin-Shiang Lin
  • Publication number: 20070093485
    Abstract: Disclosed are certain substituted N-phenylsulfonamide derivatives and related compounds. These compounds are useful as bradykinin antagonists to relieve adverse symptoms in mammals mediated, at least in part, by bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.
    Type: Application
    Filed: December 18, 2003
    Publication date: April 26, 2007
    Inventors: Francine Farouz, Michael Dappen, Ying-Zi Xu, Sarah Bartulis, Ryan Holcomb, Ramesh Kasar, Michael Pleiss, Eugene Thorsett, Xiaocong Ye, Andrei Konradi
  • Publication number: 20050215565
    Abstract: The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
    Type: Application
    Filed: January 26, 2004
    Publication date: September 29, 2005
    Inventors: Stephen Karlik, Michael Pleiss, Andrei Konradi, Francine Farouz, Christopher Semko, Darren Dressen, Elizabeth Messersmith, Stephen Freedman, Ted Yednock
  • Publication number: 20050069541
    Abstract: The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
    Type: Application
    Filed: January 26, 2004
    Publication date: March 31, 2005
    Inventors: Stephen Karlik, Michael Pleiss, Andrei Konradi, Francine Farouz, Christopher Semko, Darren Dressen, Elizabeth Messersmith, Stephen Freedman, Ted Yednock