Patents by Inventor Francis E. Gould

Francis E. Gould has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5334691
    Abstract: The strength and integrity of hydrophilic polyurethane resins prepared by reacting a diol component, an organic chain extender and an organic diisocyanate are improved by critical selection of the diol component, the amount of water in the reaction mixture and the mole ratios of the reactants. The diol component is at least one of (1) a long chain poly(oxyethylene) glycol of molecular weight above 2500 and (2) a medium chain poly(oxyethylene) glycol or polyester glycol of 250-2500 molecular weight. The chain extender is a difunctional compound having a molecular weight of less than 250. The amount of water in the reaction mixture is 0.5 to 2.5 weight % and the urea content of the resins is from about 13.6 to 33.7 weight %.
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: August 2, 1994
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 5273742
    Abstract: A method for treating a body condition comprising introducing an aqueous solution of a water soluble polyether polyurethane into said body condition.
    Type: Grant
    Filed: December 30, 1991
    Date of Patent: December 28, 1993
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Murray H. Reich
  • Patent number: 5120816
    Abstract: The strength and integrity of hydrophilic polyurethane resins prepared by reacting a diol component, an organic chain extender and an organic diisocyanate are improved by critical selection of the diol component, the amount of water in the reaction mixture and the mole rations of the reactants. The diol component is at least one of (1) a long chain poly(oxyethylene) glycol of molecular weight above 2500 and (2) a medium chain poly(oxyethylene) glycol or polyester glycol of 250-2500 molecular weight. The chain extender is a difunctional compound having a molecular weight of less than 250. The amount of water in the reaction mixture is 0.5 to 2.5 weight % and the urea content of the resins is from about 13.6 to 33.7 weight %.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: June 9, 1992
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 5000955
    Abstract: Thermally reversible polyurethane hydrogels are formed by adding water to a gel forming hydrophilic polyurethane polymer produced by reacting under anhydrous conditions a non-aromatic organic diisocyanate with a glycol component in an NCO/OH mole weight ratio of from about 0.900/1 to about 0.980/1, the glycol component having a number average molecular weight of from about 1000 to 3500 wherein the percentage by weight of the diisocyanate in the reaction mixture is from about 7% to about 20%. The hydrogels are solids at room temperature but liquify at higher temperatures such as body temperature and therefore are useful as carriers for the protection, delivery and sustained release of a variety of active agents including pharmaceuticals, cosmetics, living cells and organisms.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: March 19, 1991
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston, George E. Seems
  • Patent number: 4810543
    Abstract: The coefficient of friction of surfaces of articles, wherein the surface comprises a hydrophilic polyurethane polymer, is reduced by treating the surface with a mixture of concentrated sulfuric acid and a low molecular weight organic polyhydroxy compound, and removing excess treating mixture. Typical low friction articles produced thereby are boat hulls having drag resistant coatings, conduits having low friction linings, and cannula or body implants having slippery surfaces.
    Type: Grant
    Filed: October 17, 1986
    Date of Patent: March 7, 1989
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Charles K. Kliment, George E. Seems
  • Patent number: 4810582
    Abstract: Water absorptive polyurethane composition, having high mechanical strength, is formed of A. about 25% to about 75% of a hydrophilic polyether polyurethane which is the reaction product of diethylene glycol and a polyoxyethylene glycol having a molecular weight of about 1000 to about 8000 with a polyisocyanate and B. about 75% to about 25% of a hydrophobic polyester polyurethane which is the reaction product of a polyfunctional polyester derived from the condensation of a polyol with a polybasic acid with a polyisocyanate.
    Type: Grant
    Filed: March 18, 1988
    Date of Patent: March 7, 1989
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Ellen K. Morgan, Stephen D. Reduker
  • Patent number: 4798876
    Abstract: Water absorptive polyurethane composition, having high mechanical strength, is formed of A. about 25% to about 75% of a hydrophilic polyether polyurethane which is the reaction product of diethylene glycol and a polyoxyethylene glycol having a molecular weight of about 1000 to about 8000 with a polyisocyanate and B. about 75% to about 25% of a hydrophobic polyester polyurethane which is the reaction product of a polyfunctional polyester derived from the condensation of a polyol with a polybasic acid with a polyisocyanate.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 17, 1989
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Ellen K. Morgan, Stephen D. Reduker
  • Patent number: 4780512
    Abstract: Polyurethane acrylate compositions are obtained by reacting 100 parts of a hydrophilic polyurethane resin in the presence of from about 10 to about 50 parts of an acrylate. The resulting products will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane acrylate compositions may be molded to form shaped products that swell in water and have a variety of uses.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: October 25, 1988
    Assignee: Tyndale Plains-Hunter Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4496535
    Abstract: Shaped three-dimensional structures formed of polyurethane polyene compositions obtained by reacting from about 10 to about 50 parts by weight of a polyene in the presence of about 100 parts by weight of a hydrophilic polyurethane resin. The resulting products will swell and increase in weight upon immersion in water and are permeable to gases, moisture vapor, ions, and other low molecular weight species. The hydrophilic polyurethane polyene compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: January 29, 1985
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4490423
    Abstract: Three-dimensional substrates having on at least one surface a coating formed of a polyurethane polyene composition obtained by reacting from about 10 to about 50 parts by weight of a polyene in the presence of about 100 parts by weight of a hydrophilic polyurethane resin. Transparent substrates are rendered antifogging by such coatings. The drag resistance of boat hulls may be decreased by a coating of the compositions and marine growth thereon may be inhibited by incorporating substances such as mercurous acetate in the coating.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: December 25, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4454309
    Abstract: Polyurethane polyene compositions are obtained by reacting from about 10 to about 50 parts by weight of a polyene in the presence of about 100 parts by weight of a hydrophilic polyurethane resin. The resulting products will swell and increase in weight upon immersion in water and are permeable to gases, moisture vapor ions, and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory.
    Type: Grant
    Filed: October 8, 1982
    Date of Patent: June 12, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4451635
    Abstract: Polyurethane quaternary ammonium salts are obtained by heating a solution of a polyurethane resin characterized by having present in the polymer backbone hydroxyl groups and at least one substituent selected from the group consisting of carboxylate radicals and carboxyl radicals dissolved in a water-miscible organic solvent for the resin at a temperature above 64.degree. C. and below the decomposition temperature of said polyurethane resin with an organic chloride for a period of time; adding a strong base to the reaction mixture and continuing to heat said mixture to form a polyurethane quaternary ammonium hydroxide in solution; and precipitating the polyurethane quaternary ammonium hydroxide by pouring the reaction mixture into an excess of water.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: May 29, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4439583
    Abstract: Canulae formed of or having a coating of polyurethane diacrylate compositions obtained by reacting a diacrylate in the presence of from about 65 to about 95 weight percent of a hydrophilic polyurethane resin. The compositions will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory.
    Type: Grant
    Filed: September 1, 1982
    Date of Patent: March 27, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4439584
    Abstract: Gas and ion permeable membranes useful as burn dressings, surgical drapes and the like formed of polyurethane diacrylate compositions obtained by reacting a diacrylate in the presence of from about 65 to about 95 weight percent of a hydrophilic polyurethane resin. The compositions will form a hydrogel upon immersion in water and are also permeable to other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory.
    Type: Grant
    Filed: September 1, 1982
    Date of Patent: March 27, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4439585
    Abstract: Polyurethane diacrylate compositions are obtained by reacting a diacrylate in the presence of from about 65 to about 95 weight percent of a hydrophilic polyurethane resin. The compositions will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory. The compositions are useful as carriers for pharmacologically active agents in forming an oral delivery system.
    Type: Grant
    Filed: September 2, 1982
    Date of Patent: March 27, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4424305
    Abstract: Surgical implants, intrauterine devices and the like formed of polyurethane diacrylate compositions obtained by reacting a diacrylate in the presence of from about 65 to about 95 weight percent of a hydrophilic polyurethane resin. The compositions will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory. The shaped products contain distributed therein a desired medicament.
    Type: Grant
    Filed: September 1, 1982
    Date of Patent: January 3, 1984
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4408023
    Abstract: Polyurethane diacrylate compositions are obtained by reacting a diacrylate in the presence of from about 30 to about 95 weight percent of a hydrophilic polyurethane resin. The resulting products will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory. The compositions are useful for making contact lenses and numerous forms of surgical devices, among other things.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: October 4, 1983
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4359558
    Abstract: Polyurethane diacrylate compositions are obtained by reacting a diacrylate in the presence of from about 30 to about 95 weight percent of a hydrophilic polyurethane resin. The resulting products will form a hydrogel upon immersion in water and are permeable to gases, ions and other low molecular weight species. The hydrophilic polyurethane diacrylate compositions may be molded to form shaped products that are dimensionally stable after repeated exposure to boiling water and exhibit memory.
    Type: Grant
    Filed: November 12, 1980
    Date of Patent: November 16, 1982
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Francis E. Gould, Christian W. Johnston
  • Patent number: 4255550
    Abstract: Water insoluble polyurethane polyether polymers that are soluble in ethanol at pH 11 characterized by a molecular weight above 6,000 and having carboxylate groups and hydroxyl groups in the polymer backbone are prepared by reacting a mixture of polyols, a polyfunctional lactone and a polyfunctional isocyanate proportioned so as to provide the desired polymer properties. The polymer so prepared contains lactone groups and hydroxyl groups in the polymer backbone. The lactone ring is opened by treating the polymer with an alkaline aqueous solution of a water miscible organic solvent to produce a water insoluble polyurethane polyether resin containing carboxylate groups and hydroxyl groups in the polymer backbone. The carboxylate groups may be in the form of a carboxylic acid group or its alkali metal or quaternary ammonium salt. The product is soluble in mixtures of water with a water miscible organic solvent and may be used in the preparation of surgical drapes and burn dressings.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: March 10, 1981
    Assignee: Tyndale Plains - Hunter Ltd.
    Inventor: Francis E. Gould
  • Patent number: 4156066
    Abstract: Polyurethane polymers characterized by a molecular weight above 6,000 and having lactone groups and hydroxyl groups in the polymer backbone are prepared by reacting a mixture of polyglycols proportioned so as to provide the desired polymer properties, a polyfunctional lactone and a polyfunctional isocyanate. The product is soluble in alkaline solutions and may be used for light sensitive photographic layers on films, paper or glass; in drug delivery systems, as burn dressings, in body implants such as vascular prosthesis, and in the manufacture of catheters. The novel polymers also find use in the manufacture of artificial finger nails, finger cots, adhesives, and in protective and hydrostatic drag resistant coatings. The water absorptivity of the polyurethane lactone polymers is above 10%, preferably above 20%, and these polymers may range to completely gel-like high water absorptive polymers.
    Type: Grant
    Filed: June 23, 1977
    Date of Patent: May 22, 1979
    Assignee: Tyndale Plains - Hunter Ltd.
    Inventor: Francis E. Gould