Patents by Inventor Francis X. Sullivan

Francis X. Sullivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7879885
    Abstract: The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: February 1, 2011
    Assignee: Array Biopharma, Inc.
    Inventors: Steven A. Boyd, Kevin R. Condroski, Allen Thomas, Stephen S. Gonzales, Indrani W. Gunawardana, Yvan Le Huerou, Todd T. Romoff, Francis X. Sullivan
  • Patent number: 7809536
    Abstract: A method, system, computer system, and computer-readable medium to provide an interface for defining a model of a particular functionality of an information processing system. Intelligent models can be defined that can be used by an application to discover actual relationship, dependency, or configuration data for components of an information processing system. Models can be defined to include a set of one or more instructions to discover data about an existing information system, where the data are related to the specific information processing function being modeled. Models provide a context for analyzing and evaluating the functionality of an information processing system. The interface can also be used to define the model itself, including components of the model, properties of the components, and relationships between components.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: October 5, 2010
    Assignee: Motive, Inc.
    Inventors: Duke P. Browning, Francis X. Sullivan
  • Publication number: 20090209554
    Abstract: The present invention provides N-3?-pyridyl-methyl or N-2?-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X? are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
    Type: Application
    Filed: March 23, 2005
    Publication date: August 20, 2009
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Steven A. Boyd, Kevin R. Condroski, Jason De Meese, Stephen S. Gonzales, Indrani W. Gunawardana, Tomas Kaplan, Yvan Le Huerou, Joseph Lyssikatos, Todd T. Romoff, Francis X. Sullivan, Allen Thomas
  • Patent number: 7536290
    Abstract: A method, system, computer system, and computer-readable medium to create a snapshot of an existing information system using a model of an information processing system. The model defines a set of instructions that is operable to discover data about a resource in the existing information processing system, and the snapshot is created by executing the set of instructions. An analysis of the snapshot is performed to identify a set of actions needed to make a change to the existing information processing system. Changes to the existing information processing system may include, for example, upgrading the existing information processing system, deploying a new instance of the existing information processing system, and optimizing performance of the existing information processing system.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: May 19, 2009
    Assignee: Silicon Valley Bank
    Inventors: Duke P. Browning, Francis X. Sullivan
  • Patent number: 7155346
    Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 26, 2006
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Andrea M. Olland, Mark L. Stahl, Francis X. Sullivan, Kathryn W. Underwood, Rajiv Chopra
  • Patent number: 6999990
    Abstract: A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins initiates a guided self-help session in response to entry by a user of a problem area and description. During the self-help session, the user is provided with an option to escalate to live help. If the user exercises that option, the system automatically provides a support engineer at the server with a data stream summarizing the self-help session. During the live help, the support engineer may then repeat a portion of the user's self-help session, view information generated during that session, and/or execute certain actions with respect to the user's machine, all from the engineer's desktop. An active journal is maintained for each problem incident, and active journals may be used by other analysts to facilitate problem resolutions for new incidents.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: February 14, 2006
    Assignee: Motive, Inc.
    Inventors: Francis X. Sullivan, Brian Jay Vetter
  • Patent number: 6694314
    Abstract: A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins in response to entry by a user of a problem area and description. In response, a diagnostic map is executed to explore the user's machine and the problem description. The map returns a self-help search string that, upon execution in a search engine, is expected to return relevant search results. The search string may then be executed to facilitate a guided self-help session.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: February 17, 2004
    Assignee: Motive Communications, Inc.
    Inventors: Francis X. Sullivan, Thomas William Bereiter, Brian Jay Vetter
  • Patent number: 6658598
    Abstract: Guided self-help is facilitated through use of so-called “active content” pages that are selectively filtered and retrieved as a function of a set of declarative “assertions.” An assertion typically is an individual statement or building block of a larger, more comprehensive diagnostic map. An assertions map is a smaller, more focused version of a diagnostic map that is executed against a user's computer system to diagnose a particular problem situation that the user has encountered. When a user encounters a technical problem, he or she navigates to a search window and enables a given command when entering a search string to identify fixes for the problem. A server process responds to the search request and downloads an assertions map that checks the state of the end user system and returns results.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: December 2, 2003
    Assignee: Motive Communications, Inc.
    Inventor: Francis X. Sullivan
  • Patent number: 6615240
    Abstract: A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins initiates a guided self-help session in response to entry by a user of a problem area and description. During the self-help session, the user is provided with an option to escalate to live help. If the user exercises that option, the system automatically provides a support engineer at the server with a data stream summarizing the self-help session. During the live help, the support engineer may then repeat a portion of the user's self-help session, view information generated during that session, and/or execute certain actions with respect to the user's machine, all from the engineer's desktop.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: September 2, 2003
    Assignee: Motive Communications, Inc.
    Inventors: Francis X. Sullivan, Thomas William Bereiter, Brian Jay Vetter
  • Publication number: 20030124699
    Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.
    Type: Application
    Filed: July 31, 2002
    Publication date: July 3, 2003
    Inventors: Andrea M. Olland, Mark L. Stahl, Francis X. Sullivan, Kathryn W. Underwood, Rajiv Chopra
  • Patent number: 6542898
    Abstract: Guided self-help is facilitated through use of so-called “active content” pages that are selectively viewable by given “audiences” within a technical support chain automation system. Active content is Web-based content (e.g., content viewable by a Web browser) that has one or more diagnostic maps initiated when certain actions are taken According to the invention, users are assigned to a hierarchy of audiences. A given audience within the hierarchy has the right to view active content written for that audience and active content written for any audience within the hierarchy at a lower level in the hierarchy. Given segments or portions of an active content database are associated with given audiences in the hierarchy. Thus, during a guided technical support session initiated by a user, given active content is served to the user as a function of the audience to which the user has been assigned.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: April 1, 2003
    Assignee: Motive Communications, Inc.
    Inventors: Francis X. Sullivan, Brian Jay Vetter
  • Patent number: 6477531
    Abstract: A method for automated technical support in a computer network having a client machine, and at least one server. The method begins in response to entry by a user of a problem areas and description. During a guided self-help session, the user is presented with active content, for example, technical support information that may be “activated” via a diagnostic map. A given diagnostic map encapsulates a set of one or more methods that, upon execution, explore the user's machine and gathers diagnostic data. The active content is useful to facilitate diagnosis or self-repair during the self-help session.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: November 5, 2002
    Assignee: Motive Communications, Inc.
    Inventors: Francis X. Sullivan, Brian Jay Vetter
  • Patent number: 6459996
    Abstract: The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 1, 2002
    Assignee: American Home Products Corporation
    Inventors: William S. Somers, Mark L. Stahl, Francis X. Sullivan