Patents by Inventor Francisco Xavier Talamas

Francisco Xavier Talamas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienopyridazines as IKK inhibitors
    Patent number: 7135470
    Abstract: The invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R1 are as defined herein. Also provided are compositions comprising, methods of preparing, and methods for using the subject compounds.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: November 14, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas
  • Synthesis of purine derivatives
    Patent number: 7105666
    Abstract: The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: September 12, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Lars G.J. Hammarström, Nancy Elisabth Krauss, Sharada Shenvi Labadie, David Bernard Smith, Francisco Xavier Talamas
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6984637
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: January 10, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Pyrazole derivatives-p38 MAP kinase inhibitors
    Patent number: 6979693
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: December 27, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • Aminopyrimidine and aminopyridine anti-inflammation agents
    Patent number: 6846828
    Abstract: Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: January 25, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Ronald Charles Hawley, Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20040266782
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: November 21, 2003
    Publication date: December 30, 2004
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6770650
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: August 3, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Synthesis of purine derivatives
    Publication number: 20040034224
    Abstract: The present invention provides a method for producing highly substituted purine compounds from pyrimidine compounds. Furthermore, methods of the present invention allow preparation of a library of purine compounds.
    Type: Application
    Filed: June 27, 2003
    Publication date: February 19, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Lars G.J. Hammarstrom, Nancy Elisabth Krauss, Sharada Shenvi Labadie, David Bernard Smith, Francisco Xavier Talamas
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6683074
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20030153577
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: August 29, 2001
    Publication date: August 14, 2003
    Applicant: Roche Bioscience
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Aminopyrimidine and aminopyridine anti-inflammation agents
    Publication number: 20030144303
    Abstract: Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.
    Type: Application
    Filed: November 6, 2002
    Publication date: July 31, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Ronald Charles Hawley, Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas
  • Pyrazole derivatives - p38 MAP kinase inhibitors
    Publication number: 20030018051
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): 1
    Type: Application
    Filed: February 1, 2002
    Publication date: January 23, 2003
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjorgren, Francisco Xavier Talamas
  • Pyrazole derivatives - p38 MAP kinase inhibitors
    Publication number: 20020156114
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): 1
    Type: Application
    Filed: January 11, 2002
    Publication date: October 24, 2002
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brain Sjogren, Francisco Xavier Talamas
  • Pyrazole derivatives P38 MAP kinase inhibitors
    Patent number: 6444696
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 3, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • Pyrazole derivatives P38 MAP kinase inhibitors
    Publication number: 20020103245
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): 1
    Type: Application
    Filed: July 19, 2001
    Publication date: August 1, 2002
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • Pyrazole derivatives-p38 map kinase inhibitors
    Patent number: 6376527
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: April 23, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6339087
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: January 15, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives- CCR-3 receptor antagonists
    Patent number: 6323223
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: November 27, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Pyrazole derivatives P-38 MAP kinase inhibitors
    Patent number: 6316466
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: November 13, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas