Patents by Inventor Franciscus Wilhelmus Henricus Maria Merkus

Franciscus Wilhelmus Henricus Maria Merkus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9737526
    Abstract: An oromucosal solution comprising about 1-8% (w/v) apomorphine or a pharmaceutical acceptable salt thereof solubilised in a non-aqueous carrier containing at least about 50% (v/v) of propylene glycol. A small volume (25-250 ?L) of said solution containing about 1-12 mg apomorphine may be administered upon demand to treat motor fluctuations during off periods in patients suffering from Parkinson's disease. The solution may also be used for the treatment of sexual dysfunction.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: August 22, 2017
    Assignee: INNOTESTO BVBA
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Publication number: 20170112822
    Abstract: An oromucosal solution comprising about 1-8% (w/v) apomorphine or a pharmaceutical acceptable salt thereof solubilised in a non-aqueous carrier containing at least about 50% (v/v) of propylene glycol. A small volume (25-250 ?L) of said solution containing about 1-12 mg apomorphine may be administered upon demand to treat motor fluctuations during off periods in patients suffering from Parkinson's disease. The solution may also be used for the treatment of sexual dysfunction.
    Type: Application
    Filed: November 7, 2016
    Publication date: April 27, 2017
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Patent number: 9498436
    Abstract: Solutions of testosterone for oromucosal administration providing an increase in serum testosterone levels in subjects deficient in endogenous testosterone levels, and therapeutic methods for providing an increase in serum testosterone levels and methods for treating a disease or a symptom associated with deficient endogenous levels of testosterone.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: November 22, 2016
    Assignee: INNOTESTO BVBA
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Publication number: 20160271135
    Abstract: Nasal compositions, comprising an aqueous solution containing caffeine and/or theobromine in a total concentration of up to about 0.5% (w/v) and an aqueous carrier having a pH of about 6-8 and comprising physiologically acceptable salts of sodium, potassium and calcium. The nasal composition when used as a nasal spray or as nasal drops or irrigation fluid is able to clean the nasal passages and to stimulate nasal mucociliary clearance and, in contrast to nasal decongestants, may be used on a daily-basis for a period longer than 5 days.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 22, 2016
    Applicants: INNOTESTO BVBA, Veramed B.V.
    Inventors: Franciscus Wilhelmus Henricus Maria Merkus, Bart Merkus
  • Publication number: 20160256473
    Abstract: The present invention relates to low dose estradiol solutions for oromucosal administration suitable in replacement therapy or suppletion of low estradiol levels and also for preventing, alleviating or treating symptoms associated with low endogenous levels of estradiol in female subjects.
    Type: Application
    Filed: May 16, 2016
    Publication date: September 8, 2016
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Patent number: 9402811
    Abstract: The present invention relates to low dose estradiol solutions for oromucosal administration suitable in replacement therapy or suppletion of low estradiol levels and also for preventing, alleviating or treating symptoms associated with low endogenous levels of estradiol in female subjects.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: August 2, 2016
    Assignee: INNOTESTO BVBA
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Publication number: 20150272872
    Abstract: An oromucosal solution comprising about 1-8% (w/v) apomorphine or a pharmaceutical acceptable salt thereof solubilised in a non-aqueous carrier containing at least about 50% (v/v) of propylene glycol. A small volume (25-250 ?L) of said solution containing about 1-12 mg apomorphine may be administered upon demand to treat motor fluctuations during off periods in patients suffering from Parkinson's disease. The solution may also be used for the treatment of sexual dysfunction.
    Type: Application
    Filed: September 27, 2013
    Publication date: October 1, 2015
    Applicant: INNOTESTO BVBA
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Publication number: 20140371191
    Abstract: The present invention relates to low dose estradiol solutions for oromucosal administration suitable in replacement therapy or suppletion of low estradiol levels and also for preventing, alleviating or treating symptoms associated with low endogenous levels of estradiol in female subjects.
    Type: Application
    Filed: January 4, 2013
    Publication date: December 18, 2014
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Publication number: 20130143851
    Abstract: Solutions of testosterone for oromucosal administration providing an increase in serum testosterone levels in subjects deficient in endogenous testosterone levels, and therapeutic methods for providing an increase in serum testosterone levels and methods for treating a disease or a symptom associated with deficient endogenous levels of testosterone.
    Type: Application
    Filed: August 9, 2011
    Publication date: June 6, 2013
    Applicant: INNOTESTO BVBA
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus
  • Patent number: 7700588
    Abstract: Compositions of midazolam, a benzodiazapine, in concentrations of 35-100 mg/ml are disclosed for the treatment of anxiety, epilepsy and epileptic seizures, invasive surgical procedures and diagnostic procedures and sedation. These compositions are particularly characterized by a solubilizer such an propylene glycol. Preferably, the compositions are aqueous solutions for intranasal administration.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: April 20, 2010
    Inventor: Franciscus Wilhelmus Henricus Maria Merkus