Patents by Inventor Francois Binette
Francois Binette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140163695Abstract: A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.Type: ApplicationFiled: February 13, 2014Publication date: June 12, 2014Applicant: DePuy Mitek, LLCInventors: Keith M. Orr, Eric Hyman, Francois Binette, Ian D. McRury, Steve Lepke, Ash Perkins, Julia Hwang
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Patent number: 8691259Abstract: A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.Type: GrantFiled: November 16, 2005Date of Patent: April 8, 2014Assignee: DePuy Mitek, LLCInventors: Steven M. Bowman, Izi Bruker, Alireza Rezania, Mora Carolynne Melican, Francois Binette, Julia Hwang
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Publication number: 20140081209Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: ApplicationFiled: November 21, 2013Publication date: March 20, 2014Applicant: DePuy Mitek, LLCInventors: Brooks J. Story, Francois Binette, M.E. Liesbeth Brown
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Patent number: 8673021Abstract: A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.Type: GrantFiled: November 26, 2003Date of Patent: March 18, 2014Assignee: DePuy Mitek, LLCInventors: Keith M. Orr, Eric Hyman, Francois Binette, Ian D. Mcrury, Steve Lepke, Ash Perkins, Julia Hwang
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Patent number: 8592201Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: GrantFiled: August 6, 2012Date of Patent: November 26, 2013Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Patent number: 8562542Abstract: A biological tissue collection device is provided having a housing with a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold. The scaffold is preferably retained in the housing in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber. The collection device further includes a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber. As the fluid is displaced, any biological tissue deposited on the tissue scaffold is dispersed within the fluid. Removal of the force enables the fluid to return to the second chamber and thereby deposit the tissue onto the tissue scaffold. In an exemplary embodiment, the tissue is deposited evenly onto the tissue scaffold.Type: GrantFiled: July 15, 2010Date of Patent: October 22, 2013Assignee: DePuy Mitek, LLCInventors: Francois Binette, Julia Hwang, Keith M. Orr, Steve Lepke, Eric Hyman, Ashley Perkins
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Patent number: 8496970Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: February 27, 2012Date of Patent: July 30, 2013Assignee: DePuy Mitek, LLCInventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 8394369Abstract: Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: August 10, 2006Date of Patent: March 12, 2013Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Brooks J. Story
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Patent number: 8354100Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: March 23, 2011Date of Patent: January 15, 2013Assignee: DePuy Mitek, Inc.Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Publication number: 20120302958Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: ApplicationFiled: August 6, 2012Publication date: November 29, 2012Applicant: JOHNSON & JOHNSON REGENERATIVE THERAPEUTICS, LLCInventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Patent number: 8257963Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: GrantFiled: May 20, 2008Date of Patent: September 4, 2012Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Brooks J. Story, M. E. Liesbeth Brown
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Publication number: 20120189619Abstract: Effective methods of treating a spinal disorder or osteoarthritis associated with a proinflammatory agent in a patient in need of such treatment, the method comprising administering an effective amount of DN-TNF (e.g., XPro®-1595) to a target tissue site at or near the spine or osteoarthritic joint to reduce pain and/or inflammation.Type: ApplicationFiled: October 24, 2011Publication date: July 26, 2012Applicant: WARSAW ORTHOPEDIC, INC.Inventor: Francois Binette
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Publication number: 20120156265Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: ApplicationFiled: February 27, 2012Publication date: June 21, 2012Applicant: DEPUY MITEK, INC.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 8153117Abstract: Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: August 10, 2006Date of Patent: April 10, 2012Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Brooks J. Story
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Patent number: 8137702Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: December 29, 2010Date of Patent: March 20, 2012Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Publication number: 20110171186Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: ApplicationFiled: March 23, 2011Publication date: July 14, 2011Applicant: DEPUY MITEK, INC.Inventors: Brooks J. Story, Francois Binette, M. E. L. Brown
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Publication number: 20110097381Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: ApplicationFiled: December 29, 2010Publication date: April 28, 2011Applicant: DEPUY MITEK, INC.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Publication number: 20110091517Abstract: A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.Type: ApplicationFiled: November 22, 2010Publication date: April 21, 2011Applicant: DEPUY MITEK, INC.Inventors: Francois Binette, Julia Hwang, Sridevi Dhanaraj, Anna Gosiewska
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Patent number: 7927599Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: December 4, 2008Date of Patent: April 19, 2011Assignee: Ethicon, Inc.Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Patent number: 7897384Abstract: Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: September 8, 2003Date of Patent: March 1, 2011Assignee: Ethicon, Inc.Inventors: Francois Binette, Brooks J. Story