Abstract: Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3?, 5?-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.

Abstract: A user interface for a snow groomer or other tracked vehicle, such as tracked carrier to carry and enable use of work equipment on various terrains, is provided. The user interface may comprise an input device, an output device and a controller. The controller is configured to receive from the input device an indication of a desired snow grooming distance, and the controller is further configured to measure a distance traveled by the snow groomer, and to cause the output device to convey a remaining distance to be traveled by the snow groomer, the remaining distance being the difference between the desired snow grooming distance and the distance traveled by the snow groomer.

Abstract: Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3?, 5?-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.

Abstract: A user interface for a snow groomer or other tracked vehicle, such as tracked carrier to carry and enable use of work equipment on various terrains, is provided. The user interface may comprise an input device, an output device and a controller. The controller is configured to receive from the input device an indication of a desired snow grooming distance, and the controller is further configured to measure a distance traveled by the snow groomer, and to cause the output device to convey a remaining distance to be traveled by the snow groomer, the remaining distance being the difference between the desired snow grooming distance and the distance traveled by the snow groomer.

Abstract: A user interface for a snow groomer or other tracked vehicle, such as tracked carrier to carry and enable use of work equipment on various terrains, is provided. The user interface may have an input device, an output device and a controller. The controller is configured to receive from the input device an indication of a desired snow grooming distance, and the controller is further configured to measure a distance traveled by the snow groomer, and to cause the output device to convey a remaining distance to be traveled by the snow groomer, the remaining distance being the difference between the desired snow grooming distance and the distance traveled by the snow groomer.

Abstract: Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3?, 5?-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.

Abstract: The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3?, 5?-monophosphate analogs as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.

Abstract: A snow groomer or other tracked vehicle, such as tracked carrier to carry and enable use of work equipment on various terrains, is provided. The snow groomer may comprise a chassis, an operator cabin mounted to the chassis from which operation of the snow groomer is controlled, track assemblies for causing the snow groomer to advance, a power plant in a driving relationship with the track assemblies, and a tiller assembly attached at the rear of the chassis. The operator cabin comprises a seating system that includes an operator seat, a base, and a seat carriage mounted to the base, which allows the operator seat both to move in a direction transverse to the direction of motion of the snow groomer, and to pivot about an axis.

Abstract: The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3?,5 ‘-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.

Abstract: A cross-link for a track that comprises belts spaced apart to accommodate a plurality of wheels of a tracked vehicle on which the track is mounted, the belts having a ground-facing side. In one embodiment, the cross-link comprises an elongate member for mounting to the belts to interconnect the belts, the elongate member having a belt-engaging face contacting the belts on the ground-facing side when the elongate member is mounted to the belts. The elongate member defines a channel including a bottom portion and a pair of sidewalls opposite one another on either side of the bottom portion. The cross-link also comprises a sole mountable in the channel for engaging a ground surface on which the tracked vehicle travels, the sole comprising a pair of sidewall-engaging surfaces for engaging the sidewalls when the sole is mounted in the channel.

Abstract: A tracked vehicle (e.g., a tracked carrier vehicle) comprising a plurality of track assemblies for traction of the tracked vehicle. Each of the track assemblies supports a portion of a weight of the tracked vehicle when the tracked vehicle is in use. Each track assembly comprises: a first wheel and a second wheel spaced apart from one another along a longitudinal direction of the tracked vehicle; a number of support wheels arranged in an in-line configuration between the first wheel and the second wheel; and an endless track disposed around the first wheel, the second wheel, and the support wheels. The support wheels may comprise at least five (5) support wheels mounted such that, when the tracked vehicle is in use, the portion of the weight of the tracked vehicle supported by the track assembly is never applied to only one of the support wheels.

Abstract: A cross-link for a track of a tracked vehicle, such as a tracked carrier vehicle. The track comprises a plurality of belts spaced apart to accommodate a plurality of wheels of the tracked vehicle, the belts having a ground-facing side for facing the ground. The cross-link comprises an elongate member for mounting to the belts to interconnect the belts. The elongate member has a belt-engaging face contacting the belts on the ground-facing side when the elongate member is mounted to the belts. The cross-link also comprises a sole mountable to the elongate member. The sole comprises a ground-engaging portion for engaging the ground. A ground contact area of the sole may be substantially different from a projected area of the elongate member onto the ground. For example, a length of the ground-engaging portion of the sole may be substantially different from a length of the elongate member.

Abstract: A tracked vehicle (e.g., a tracked carrier vehicle) comprising a plurality of track assemblies for traction of the tracked vehicle. Each of the track assemblies supports a portion of a weight of the tracked vehicle when the tracked vehicle is in use. Each track assembly comprises: a first wheel and a second wheel spaced apart from one another along a longitudinal direction of the tracked vehicle; a number of support wheels arranged in an in-line configuration between the first wheel and the second wheel; and an endless track disposed around the first wheel, the second wheel, and the support wheels. The support wheels may comprise at least five (5) support wheels mounted such that, when the tracked vehicle is in use, the portion of the weight of the tracked vehicle supported by the track assembly is never applied to only one of the support wheels.

Abstract: A cross-link for a track that comprises belts spaced apart to accommodate a plurality of wheels of a tracked vehicle on which the track is mounted, the belts having a ground-facing side. In one embodiment, the cross-link comprises an elongate member for mounting to the belts to interconnect the belts, the elongate member having a belt-engaging face contacting the belts on the ground-facing side when the elongate member is mounted to the belts. The elongate member defines a channel including a bottom portion and a pair of sidewalls opposite one another on either side of the bottom portion. The cross-link also comprises a sole mountable in the channel for engaging a ground surface on which the tracked vehicle travels, the sole comprising a pair of sidewall-engaging surfaces for engaging the sidewalls when the sole is mounted in the channel.

Abstract: A method, system, device, and computer storage medium for use in communicating a video feed transmitted from a video monitoring device to a video enabled communication device. The video enabled communication device and the video monitoring device communicate via a communication network in a session initiation protocol (SIP) session. In accordance with a SIP initiation path, a SIP session is established between the video monitoring device and the video enabled communication device. After establishing the SIP session, in accordance with a media path between the video monitoring device and the video enabled communication device, a video feed is received from the video monitoring device. The received video feed is transcoded. In accordance with the media path, the transcoded video feed is transmitted to the video enabled communication device.

Abstract: A Francis runner that includes a crown, a band and blades which extend between the crown and the band. An angle (?24) between a linear speed (U, D224) of one of the blades and a median of the blade at the trailing edge, has a value between 20 and 25°. As a result, a machine utilizing the Francis runner of the invention is efficient, while an equivalent power under high load is high.

Abstract: The invention relates to a Francis runner comprising a crown, a band and blades (2) which extend between the crown and the band. The value of the angle (?24) between the linear speed (U, D224) of a blade (2) and the median (25, ?214) of said blade (2) at the trailing edge (22) has, in the vicinity of the point (224) at which the blade (2) is attached to the band, has a value included between 20 and 25°. In this way, the machine has a satisfactory efficiency while the equivalent power under high load can be high.

Abstract: A hybrid remote-sensing apparatus is based on an active high-power microwave (HPM) illuminator and a passive infrared (IR) detector for the detection of shallow buried landmines. A 2.45 GHz, 5 kW microwave source is used for illumination and the thermal signature at the soil surface is detected in the 8-12 &mgr;m region both in near real-time as well as after a brief time-delay following illumination. The thermal signature at the soil surface is primarily made up of two components. A thermal signature occurs at the soil surface in near real-time due to the interference of the incident beam and the beam reflected by buried mines. A second thermal signature is generated when temperature contrasts due to differential microwave absorption by a mine and the surrounding soil are conducted upwards from that mine location to the surface. Both signatures are dependent on the complex dielectric constants of mines and the soil.

Abstract: Waste/industrial effluents containing contaminating amounts of organic and/or inorganic species, for example effluents containing sulfate or sulfuric acid values, or effluents emanating from the production of methionine, are safely and effectively purified in high yield, by first establishing, in a first reaction zone, an axially helically descending flowstream defining a phase of combustion, this phase of combustion comprising ignited admixture of a first oxidizing fluid and a combustible fuel; ejecting the phase of combustion through a port of restricted flow passage to impart an axially symmetrical vortex flow thereto and flash-expanding same into a second reaction zone; introducing effluent to be purified into the axially symmetrical vortex thus formed; and also introducing additional oxidizing fluid into such axially symmetrical vortex, whereby the effluent is disintegrated into a multitude of droplets entrained in unit volumes of the phase of combustion and thermally treated in the second reaction zone.

Abstract: A rebalance loop for controlling a dry tuned rotor gyroscope having a rotor moveable about two orthogonal axes, a first pickoff associated with one of the axes for producing an electrical error signal when a rate is applied to one of the axes, a second pickoff associated with the other of the axes for producing an electrical error signal when a rate is applied to that axis and a pair of torquer coil adapted to receive electrical control signals from the rebalance loop and apply torques to the rotor about the two axes for correcting errors detected by the pickoffs.