Patents by Inventor Frank L. Weisenborn

Frank L. Weisenborn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enkephalinase inhibitors
    Patent number: 4474799
    Abstract: The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Roland Greenberg, David W. Cushman, B. Richard Vogt, Frank L. Weisenborn, Michael J. Antonaccio
  • Enkephalinase inhibitors
    Patent number: 4474795
    Abstract: The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Roland Greenberg, David W. Cushman, B. Richard Vogt, Frank L. Weisenborn, Michael J. Antonaccio
  • Enkephalinase inhibitors
    Patent number: 4401677
    Abstract: The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: August 30, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Roland Greenberg, David W. Cushman, B. Richard Vogt, Frank L. Weisenborn, Michael J. Antonaccio
  • Steroid derivatives and their use in radioimmunoassays
    Patent number: 4345096
    Abstract: Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radio-immunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: August 17, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • 4-Azido-1-mercaptoacyl pipecolic acid
    Patent number: 4308388
    Abstract: 1-Mercaptoacyl proline or pipecolic acid having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: December 29, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Frank L. Weisenborn
  • Antibiotic kristenin
    Patent number: 4296101
    Abstract: A new antibiotic, designated kristenin, is produced by the microorganism Bacillus subtilis. The antibiotic possesses activity against gram positive bacteria.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: October 20, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frank L. Weisenborn, William E. Brown, Edward Meyers
  • 4-Azido-1-mercaptoacyl proline
    Patent number: 4296033
    Abstract: 1-Mercaptoacyl proline having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
    Type: Grant
    Filed: July 23, 1980
    Date of Patent: October 20, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Frank L. Weisenborn
  • Steroid derivatives and their use in radioimmunoassays
    Patent number: 4230621
    Abstract: Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: October 28, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes
    Patent number: 4228077
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein B is indolyl-lower alkylene.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: October 14, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Steroid derivatives and their use in radioimmunoassays
    Patent number: 4221725
    Abstract: Radiolabeled steroid derivatives having the formula ##STR1## wherein St is des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.
    Type: Grant
    Filed: January 17, 1979
    Date of Patent: September 9, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • Vitamin B.sub.12 derivative suitable for radiolabeling
    Patent number: 4209614
    Abstract: Radiolabeled vitamin B.sub.12 derivatives having the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioassays.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: June 24, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4206121
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Selenium containing derivatives of proline and pipecolic acid
    Patent number: 4181663
    Abstract: New selenium containing derivatives of proline and pipecolic acid which have the general formula ##STR1## are useful as hypotensive agents.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: January 1, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4178291
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotension converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: December 11, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4176235
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: November 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4175199
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: November 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted acyl derivatives of amino acids
    Patent number: 4154936
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Substituted thio-, sulfinyl-, and sulfonyl-alkyl benzimidazole carbamates
    Patent number: 4154846
    Abstract: Benzimidazole carbamate derivatives are provided having the structure ##STR1## wherein R is lower alkyl, lower alkenylalkyl, lower alkynylalkyl, phenyl, substituted phenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or phenylalkyl, R.sup.1 is lower alkyl, phenylalkyl or di-lower alkylaminoalkyl, Z is a single bond or a straight or branched chain alkylene group, and n is 0, 1 or 2. These compounds are useful as anthelmintic agents administered orally or parenterally.
    Type: Grant
    Filed: June 16, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Frank L. Weisenborn, Peter C. Wade, Thomas P. Kissick
  • Substituted acyl derivatives of amino acids
    Patent number: 4140864
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: February 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Steroidal 9,11-dihalo-[16.alpha.,17-b]1,4-dioxanes
    Patent number: 3971773
    Abstract: A series of novel steroidal 9,11.beta.-dihalo-[16.alpha.,17-b]-1,4-dioxanes is disclosed herein. These compounds are useful as anti-inflammatory agents.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: July 27, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Christopher M. Cimarusti, Frank L. Weisenborn, Seymour D. Levine