Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: A system for supporting a bundle of tubes against lateral movement in a heat exchanger, such as a nuclear power plant steam generator, wherein spring collar devices positioned at intervals along the tubes permit lateral movement of the tubes but prevent any relative movement between the tube and its associated spring collar device. Any lateral movement is between adjacent spring collar devices. With this arrangement, fretting and corrosion between the outer surfaces of the tubes and their lateral support members are substantially eliminated.