Abstract: A device (100) for applying a microneedle array to a skin surface. The device comprises a base (120) defining a skin contacting plane, an array component having a skin facing side comprising a microneedle array, and at least one connecting member (140) having a first portion affixed through a first hinge (142) to the base and a second portion affixed to the array component. The connecting member has a first equilibrium position with the microneedle array in a recessed position within the device and a second equilibrium position with the microneedle array positioned so as to be able to contact a skin surface.

Abstract: A process for making a microneedle array master comprises: (a) providing a photoreactive composition, the photoreactive composition comprising: (1) at least one reactive species that is capable of undergoing an acid- or radical-initiated chemical reaction, and (2) at least one multiphoton photoinitiator system; and (b) imagewise exposing at least a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of microneedles. The microneedles may be solid and the outer surface of the microneedles may be characterized by at least one concave area. The master may be used to fabricate a tool for replication.

Abstract: A microneedle patch (30) includes a base (32), at least one collapsible side wall (34) extending from the base, and a lip (36) disposed along the at least one collapsible sidewall and opposite the base. An adhesive (38) is disposed along the base, and a microneedle array (40) is affixed to the base.

Abstract: An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Abstract: A medical device (20) is provided that is suitable for use in the delivery of active component into or through the skin. The medical device comprises: an extension member (22) having a first major surface (24) and a second major surface (26), the first major surface comprising a first portion and a second portion; an array retaining member (28) extending from the first portion of the first major surface of the extension member, the array retaining member comprising an array surface (30) having at least one microneedle (32) extending from the array surface; and pressure sensitive adhesive (34) disposed on the second portion of the first major surface of the extension member to facilitate the adhesive attachment of the device to mammalian skin when the at least one microneedle is inserted through the stratum corneum.

Abstract: A patch application device wherein the patch is retained in position within the collar until delivery through contact of at least one obstruction inside the collar with a portion of an adhesive on the front surface (e.g., microneedle-containing surface) of the patch. The collar and patch can be used to form separate replaceable cartridges, and the combination can be provided as a kit.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) non-cylindrical air passageways on air horns included in an air cap portion of a body assembly that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun; (2) the air cap portion of the body assembly being mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction; and (3) the body assembly through which passes liquid sprayed by the spray gun being molded of polymeric material and being manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) a molded polymeric possibly disposable body assembly through which passes liquid sprayed by the spray gun that is manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid; (2) non-cylindrical air passageways on air horns that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun, and (3) an air cap portion of the body assembly mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) an air cap portion of a body assembly mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction; (2) non-cylindrical air passageways on air horns included in the air cap portion of the body assembly that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun; and (3) the body assembly through which passes liquid sprayed by the spray gun being molded of polymeric material and being manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid.