Patents by Inventor Frans Janssens

Frans Janssens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170065605
    Abstract: Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 9, 2017
    Inventors: Avner Ingerman, Frans Janssens, Anton Megens, Mark B. Abelson
  • Publication number: 20140107102
    Abstract: Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 17, 2014
    Applicant: Allergan, Inc.
    Inventors: Jagdish Parasrampuria, Avner Ingerman, Frans Janssens, Anton Megens
  • Patent number: 8664215
    Abstract: Compositions, kits, and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof containing alcaftadine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: March 4, 2014
    Assignee: Vistakon Pharmaceuticals, LLC
    Inventors: Avner Ingerman, Frans Janssens, Anton Megens, Mark B. Abelson
  • Publication number: 20120094978
    Abstract: Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 4, 2011
    Publication date: April 19, 2012
    Inventors: Jagdish Parasrampuria, Avner Ingerman, Frans Janssens, Anton Megens
  • Publication number: 20080096925
    Abstract: The present invention relates to novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. In particular are claimed compounds according to Formula (I) in which A=B is C?O or SO2, X is a covalent bond, R1 is alkyloxy, alkyloxyalkyl, Ar or NR9R10, wherein R9 and R10 each independently are hydrogen or Ar; or A=B and R1 together form a benzoxazolyl radical; p is zero, R3 is benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and R4 and R5 each are hydrogen. The invention also relates to processes for the preparation of the compounds according to the invention and their use in medicine, in particular as selective non-peptide ?-opioid agonists for use in the treatment of various pain conditions.
    Type: Application
    Filed: May 25, 2007
    Publication date: April 24, 2008
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Frans Janssens, Joseph Leenaerts, Francisco Fernandez-Gadea, Antonio Gomez-sanchez, Theo Meert
  • Publication number: 20080051385
    Abstract: Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 26, 2007
    Publication date: February 28, 2008
    Inventors: Jagdish Parasrampuria, Avner Ingerman, Frans Janssens, Anton Megens
  • Publication number: 20070254904
    Abstract: This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonistic activity, a combined NK1/NK3 antagonistic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence.
    Type: Application
    Filed: April 4, 2005
    Publication date: November 1, 2007
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Frans Janssens, Bruno Schoentjes, Sophie Coupa, Alain Poncelet, Yvan Simonnet
  • Publication number: 20070232636
    Abstract: This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonistic activity, a combined NK1/NK3 antagonistic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, COPD and micturition disorders such as urinary incontinence.
    Type: Application
    Filed: April 4, 2005
    Publication date: October 4, 2007
    Inventors: Frans Janssens, Bruno Schoentjes, Sophie Coupa, Alain Poncelet, Yvan Simonnet
  • Publication number: 20070213346
    Abstract: The invention concerns substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity and a combined NK1/NK3 antagonistic activity, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: April 4, 2005
    Publication date: September 13, 2007
    Inventors: Frans Janssens, Francois Sommen, Benoit Christian De Boeck, Joseph Leenaerts
  • Publication number: 20070135404
    Abstract: This invention concerns compounds of formula (I) prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and methods of their use in treating respiratory syncytial viral infections.
    Type: Application
    Filed: January 22, 2007
    Publication date: June 14, 2007
    Applicant: Janssen Pharmaceutica, N.V.
    Inventors: Frans Janssens, Kathleen Meersman, Francois Sommen, Koenraad Marcel Andries
  • Publication number: 20070093659
    Abstract: The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C1-6alkyl optionally substituted with trifluoromethyl, C3-7cycloalkyl, Ar2, hydroxy, C1-4alkoxy, C1-4alkylthio, Ar2-oxy-, Ar2-thio-, Ar2(CH2)noxy, Ar2(CH2)nthio, hydroxycarbonyl, aminocarbonyl, C1-4alkylcarbonyl, Ar2carbonyl, C1-4alkoxycarbonyl, Ar2(CH2)ncarbonyl, aminocarbonyloxy, C1-4alkylcarbonyloxy, Ar2carbonyloxy, Ar2(CH2)ncarbonyloxy, C1-4alkoxy-carbonyl(CH2)noxy, mono- or di(C1-4alkyl)aminocarbonyl, mono- or di(C1-4alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(C1-4alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-diox
    Type: Application
    Filed: December 20, 2004
    Publication date: April 26, 2007
    Inventors: Jean-Francois Bonfanti, Koenraad Andries, Frans Janssens, Francois Sommen, Jerome Guillemont, Jean Lacrampe
  • Publication number: 20070021410
    Abstract: This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3 =a4- is a radical of formula —CH?CH—CH?CH—, —N?CH—CH?CH—, —CH?N—CH?CH—, —CH?CH—N?CH—, —CH?CH—CH?N— wherein each hydrogen atom may optionally be substituted; Q is a radical of formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8). G is a direct bond or C1-10alkanediyl; R1 is an optionally substituted monocyclic heterocycle; for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections. Certain compounds of formula (I) are new.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 25, 2007
    Applicant: Janssen Pharmaceutica, N.V.
    Inventors: Frans Janssens, Kathleen Meersman, Francois Sommen, Jerome Guillemont, Jean Lacrampe, Koenraad Jozef Andries
  • Publication number: 20070015747
    Abstract: This invention concerns compounds of formula (I) prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and methods of their use in treating respiratory syncytial viral infections.
    Type: Application
    Filed: April 2, 2004
    Publication date: January 18, 2007
    Inventors: Frans Janssens, Kathleen Petrus Meersman, Francois Sommen, Koenraad Jozef Andries
  • Publication number: 20060287345
    Abstract: The present invention relates to the use of 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof as selective non-peptide ?-opioid agonists for use in the prevention and/or treatment of various central nervous system disorders, in particular as selective antidepressant and anxiolytic non-peptide ?-opioid agonists. In particular are claimed compounds according to Formula (I) in which A=B is C?O or SO2, X is a covalent bond, R1 is allyloxy, alkyloxyalkyl, Ar or NR9R10, wherein R9 and R10 each independently are hydrogen or Ar; or A=B and R1 together form a benzoxazolyl radical; p is zero, R3 is benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and R4 and R5 each are hydrogen.
    Type: Application
    Filed: April 8, 2004
    Publication date: December 21, 2006
    Inventors: Thomas Steckler, Frans Janssens, Joseph Leenaerts, Francisco Fernandez-Gadea, Antonio Gomez-Sanchez, Theo Meert
  • Publication number: 20060252747
    Abstract: This invention concerns substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK3 antagonistic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of schizophrenia, emesis, anxiety and depression, irritable bowel syndrom (IBS), circadian rhythm disturbances, visceral pain, neurogenic inflammation, asthma, micturition disorders such as urinary incontinence and nociception. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: December 17, 2003
    Publication date: November 9, 2006
    Inventors: Frans Janssens, Francois Sommen, Benoit Christian De Boeck, Joseph Leenaerts
  • Publication number: 20060167008
    Abstract: The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depression, pain, pancreatitis and IBS. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in claim 1.
    Type: Application
    Filed: October 7, 2003
    Publication date: July 27, 2006
    Inventors: Frans Janssens, Francois Sommen, Benoit Christian De Boeck, Joseph Leenaerts, Yves Van Roosbroeck, Gaston Stanislas Diels
  • Publication number: 20060154913
    Abstract: This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of formula —CH?CH—CH?CH—, —N?CH—CH?CH—, —CH?N—CH?CH—, —CH?CH—N?CH—, —CH?CH—CH?N—wherein each hydrogen atom may optionally be substituted; Q is a radical of formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8). G is a direct bond or C1-10alkanediyl; R1 is an optionally substituted monocyclic heterocycle; for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections. Certain compounds of formula (I) are new.
    Type: Application
    Filed: January 12, 2006
    Publication date: July 13, 2006
    Applicant: Janssen Pharmaceutica, N.V (BE)
    Inventors: Frans Janssens, Kathleen Meersman, Francois Sommen, Jerome Guillemont, Jean Lacrampe, Koenraad Jozef Andries
  • Publication number: 20060128721
    Abstract: This invention concerns novel formulations for opioid-based treatments of pain and/or nociception comprising opioid analgesics and 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, the use of said formulation for the manufacture of a medicament for the prevention and/or treatment of emesis, pain and/or nociception, in particular in opioid-based acute and chronic pain treatments, more in particular in inflammatory, post-operative, emergency room (ER), breakthrough, neuropathic and cancer pain treatments and the use of an NK1-receptor antagonist for the manufacture of a medicament for the prevention and/or treatment of respiratory depression in opioid-based treatments of pain.
    Type: Application
    Filed: June 7, 2004
    Publication date: June 15, 2006
    Inventors: Frans Janssens, Francois Sommen, Benoit Christian Albert Ghislain De Boeck, Joseph Elisabeth Leenaerts, Yves Emiel, Maria Van Roosbroeck, Theo Frans Meert
  • Publication number: 20060074069
    Abstract: The invention concerns substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine having neurokinin antagonistic activity, in particular NK1 and NK1/NK3-antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of schizophrenia, emesis, anxiety, depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pain, neurogenic inflammation, asthma, micturition disorders such as urinary incontinence and nociception. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
    Type: Application
    Filed: December 17, 2003
    Publication date: April 6, 2006
    Inventors: Frans Janssens, Francois Sommen, Benoit Christian Albert De Boeck, Joseph Leenaerts
  • Publication number: 20060058309
    Abstract: The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a1=a2-a3=a4- represents a radical of formula —CH?CH—CH?CH—; —N?CH—CH?CH—; —CH?N—CH?CH—; —CH?CH—N?CH—; CH?CH—CH?N—; wherein each hydrogen atom may optionally be substituted; Q is a radical of formulae (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is C1-6alkanediyl; Y1 is a bivalent radical of formula —NR2— or —CH(NR2R4); X1 is NR4, S, S(?O), S(?O)2, O, CH2, C(?O), CH(?CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2—NR4 or NR4—CH2; X2 is a direct bond, CH2, C(?O), NR4, C1-4alkyl-NR4, NR4—C1-4alkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C1-6alkyloxy, then R3 cannot replace a hydrogen atom in the ? position relative to a nitrogen atom; G is a dir
    Type: Application
    Filed: October 11, 2005
    Publication date: March 16, 2006
    Applicant: Janssen Pharmaceutica, N.V.
    Inventors: Frans Janssens, Jean Fernand Lacrampe, Jerome Guillemont, Marc Venet, Koenraad Jozef Andries