Abstract: A method for preparing an aqueous nanosuspension of API, containing the steps of preparing an aqueous suspension and a crystalline API selected from the group containing API having intrinsic solubility in water of at most 50 mg/L, and having log P of at least 4, and a combination of at least two phospholipidic stabilizing agents containing lipophilic carbohydrate chains having from 6 to 20 carbon atoms; where at least one of the stabilizing agents is PEG-coupled phospholipid of general formula (I),

Abstract: A device for preparation of liquid marbles that has a belt conveyor for carrying a layer of solid particles, the belt conveyor being provided, successively in the direction of movement of the belt with at least one solids dispenser with a reservoir for solid particles, at least one liquid dispenser with a reservoir for liquid, and a separator for separating the prepared liquid marbles from solid particles, is disclosed.

Abstract: A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.