Patents by Inventor Frederick M. Kahan

Frederick M. Kahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienamycin renal peptidase inhibitors
    Patent number: 5147868
    Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: September 15, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Donald W. Graham, Edward F. Rogers, Frederick M. Kahan
  • Combination of 2-substituted carbapenems with dipeptidase inhibitors
    Patent number: 5071843
    Abstract: A combination of a carbapenem of the formula: ##STR1## where R is H or CH.sub.3 and R.sup.1 is ##STR2## with a renal dipeptidase inhibitor is disclosed.
    Type: Grant
    Filed: April 3, 1991
    Date of Patent: December 10, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Frederick M. Kahan, Helmut Kropp
  • Combination of thienamycin-type antibiotics with dipeptidase inhibitors
    Patent number: 4880793
    Abstract: A novel antibacterial drug combination is provided, one component being a 2-substituted penem, and the other component is a dipeptidase (E.C.3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the penem are employed for 30 to 1 parts by weight of the inhibitor compound.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: November 14, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Helmut Kropp, Frederick M. Kahan
  • Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics
    Patent number: 4668504
    Abstract: Antibiotics to prevent nephrotoxicity.
    Type: Grant
    Filed: April 22, 1986
    Date of Patent: May 26, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Frederick M. Kahan, Helmut Kropp
  • Combination of thienamycin-type antibiotics with dipeptidase inhibitors
    Patent number: 4616038
    Abstract: Antibacterial compositions of thienamycin-type compounds and a dipeptidase (E.C.3.4.13.11) inhibitor.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: October 7, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Frederick M. Kahan, Helmut Kropp
  • Combination of thienamycin-type antibiotics with dipeptidase inhibitors
    Patent number: 4539208
    Abstract: A novel antibacterial drug combination is provided, one component being a fused ring .beta.-lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E.C. 3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the .beta.-lactam compound are employed for 30 to 1 parts by weight of the inhibitor compound.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: September 3, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Frederick M. Kahan, Helmut Kropp
  • Culture of Streptomyces cattleya
    Patent number: 4304867
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: January 3, 1978
    Date of Patent: December 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Process for enzymatic deacylation of antibiotics
    Patent number: 4282322
    Abstract: This invention relates to two new antibiotics, desacetyl 890A.sub.1 and desacetyl 890A.sub.3, active against both gram-positive and gram-negative bacteria, which are produced by treating 890A.sub.1 and 890A.sub.3, respectively, with an N-acetylthienamycin amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process whereby N-acetylated structures of the thienamycin class of antibiotics such as N-acetyl thienamycin can be enzymatically deacetylated.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: August 4, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Process for producing antibiotic desacetyl 890A.sub.10
    Patent number: 4264734
    Abstract: This invention relates to the new antibiotic, desacetyl 890A.sub.10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A.sub.10 with an N-acetyl-890A.sub.10 amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process by which 890A.sub.10 is enzymatically deacetylated.
    Type: Grant
    Filed: September 11, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Acetylthienamycin production
    Patent number: 4229534
    Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antiobiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • N-acetyl thienamycin
    Patent number: 4165379
    Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: August 21, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Enzymatic cleavage of N-acyl-thienamycins
    Patent number: 4162193
    Abstract: A method is disclosed for cleaving N-acyl-thienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thienamycin.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Production of N-acyl-thienamycins
    Patent number: 4135978
    Abstract: The disclosed invention is directed to a process for preparing N-acyl-thienamycins from thienamycin and the appropriate acyl group by reacting the same in the presence of certain penicillin amidohydrolases capable of producing N-acyl thienamycins.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: January 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Antibiotics
    Patent number: 4081548
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 3, 1976
    Date of Patent: March 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor
    Patent number: 4031231
    Abstract: Novel antibacterial compositions are prepared by combining 3-fluoro-D-alanine-type compound, such as 3-fluoro-D-alanine and its deutero analogs, and salts and esters thereof, with a 3-fluoro-D-alanine autoantagonist-inhibitor such as cycloserine-type compound. The compositions demonstrate highly effective antibacterial action at high levels of dosage of the 3-fluoro-D-alanine component and, in addition, possess a remarkable synergistic antibacterial action.
    Type: Grant
    Filed: January 23, 1976
    Date of Patent: June 21, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Frederick M. Kahan
  • Fluorinated amino acids
    Patent number: 4028405
    Abstract: Deutero analogs of 3-fluoro-D-alanine prepared by direct photofluorination of the D-amino acids demonstrate in vivo and in vitro antibacterial activity against both gram negative and gram positive microorganisms. Deuters analogs of 3-fluoro-L-alanine and 3-fluoro-D,L-alanine also demonstrate useful in vitro activity.
    Type: Grant
    Filed: June 7, 1976
    Date of Patent: June 7, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Frederick M. Kahan
  • Thienamycin production
    Patent number: 4006060
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Process for purifying thienamycin
    Patent number: 4000161
    Abstract: Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using ion exchange resins, poly-acrylamide gels or adsorbents such as polyester polymers or polystyrene, hydrophobic crosslinked divinyl benzene polymers.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Frederick M. Kahan
  • Antibiotics
    Patent number: 3950357
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: April 13, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez