Patents by Inventor Frenel DeMorin

Frenel DeMorin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS AND SALT FORMS OF A KINASE INHIBITOR
    Publication number: 20240300897
    Abstract: The present invention relates to crystalline forms of the free base of the c-Met inhibitor, Compound 1. The invention also relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid polymorphs of the free base and salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.
    Type: Application
    Filed: May 7, 2024
    Publication date: September 12, 2024
    Inventors: Frenel DeMorin, Khalid Shah, Sagar Shakya, Peter Wong, Courtney S. Johnson, Melanie Janelle Bevill, Stephan D. Parent
  • Crystalline forms and salt forms of a kinase inhibitor
    Patent number: 12017995
    Abstract: The present invention relates to crystalline forms of the free base of the c-Met inhibitor, Compound 1. The invention also relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid polymorphs of the free base and salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: June 25, 2024
    Assignee: Exelixis, Inc.
    Inventors: Frenel DeMorin, Khalid Shah, Sagar Shakya, Peter Wong, Courtney S. Johnson, Melanie Janelle Bevill, Stephan D. Parent
  • Processes for the Preparation of a Kinase Inhibitor
    Publication number: 20230192619
    Abstract: The present invention relates to processes for the synthetic preparation of c-Met inhibitors of Formula I, or pharmaceutically acceptable salts thereof. The present invention further relates to processes for the synthetic preparation of the c-Met inhibitor, Compound 1, or a pharmaceutically acceptable salt thereof. The present invention also relates to processes for the synthetic preparation of Compound 1.hemifumarate. The invention further relates to large scale processes for the synthetic preparation of the c-Met inhibitor, Compound 1 and Compound 1.hemifumarate.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 22, 2023
    Inventors: Frenel DeMorin, Khalid Shah, Sagar Shakya, Yong Wang, Wei Xu
  • Salt Forms of a Kinase Inhibitor
    Publication number: 20230052703
    Abstract: The present invention relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid crystalline salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 16, 2023
    Inventors: Frenel DeMorin, Khalid Shah, Sagar Shakya, Peter Wong, Courtney S. Johnson, Melanie Janelle Bevill, Stephan D. Parent
  • Crystalline Forms and Salt Forms of a Kinase Inhibitor
    Publication number: 20230029213
    Abstract: The present invention relates to crystalline forms of the free base of the c-Met inhibitor, Compound 1. The invention also relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid polymorphs of the free base and salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.
    Type: Application
    Filed: December 12, 2019
    Publication date: January 26, 2023
    Inventors: Frenel DeMorin, Khalid Shah, Sagar Shakya, Peter Wong, Courtney S. Johnson, Melanie Janelle Bevill, Stephan D. Parent
  • Aminopyrimidine compounds and methods of use
    Publication number: 20070185133
    Abstract: The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
    Type: Application
    Filed: December 16, 2005
    Publication date: August 9, 2007
    Applicant: Amgen, Inc.
    Inventors: Adrian Smith, Paul Brennan, Frenel DeMorin, Gang Liu, Nick Paras, Daniel Retz, Elizabeth Rainbeau
  • Aryl nitrogen-containing bicyclic compounds and methods of use
    Publication number: 20070054916
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: September 30, 2005
    Publication date: March 8, 2007
    Inventors: Vinod Patel, Joseph Kim, Stephanie Geuns-Meyer, Stuart Chaffee, Victor Cee, Brian Hodous, Steven Bellon, Jean-Christophe Harmange, Philip Olivieri, Maya Thaman, Erin DiMauro, John Buchanan, David McGowan, Brian Albrecht, Holly Deak, Jean Bemis, Ryan White, Matthew Martin, Gregory Habgood, Paul Tempest, Craig Masse, William Buckner, Bradley Herberich, Russell Graceffa, Dawei Zhang, Shimin Xu, Kelvin Sham, Robert Rzasa, James Falsey, Partha Chakrabarti, Guo-Qiang Cao, Susan Tomlinson, Liping Pettus, Adrian Smith, Nick Paras, Gang Liu, Frenel DeMorin, Andrew Tasker, Anthony Reed
  • Tricyclic protein kinase inhibitors
    Publication number: 20060247217
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Application
    Filed: June 29, 2006
    Publication date: November 2, 2006
    Inventors: Dan Berger, Minu Dutia, Frenel DeMorin, Diane Boschelli, Dennis Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Compounds and compositions for delivering active agents
    Publication number: 20040068013
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 8, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Patent number: 6663887
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 16, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Publication number: 20020120009
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: February 21, 2002
    Publication date: August 29, 2002
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Publication number: 20010003001
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: December 5, 2000
    Publication date: June 7, 2001
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Patent number: 6100298
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: August 8, 2000
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Patent number: 5955503
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: September 21, 1999
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Patent number: 5643957
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: July 1, 1997
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin